Results 231 to 240 of about 210,123 (350)

Ligand‐Directed Molecular Beacons as Turn‐On Fluorescent Probes for Sensing Cell‐Surface Receptor‐Ligand Interactions

Angewandte Chemie, EarlyView.
Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low, Denis Shpalter, Suraj Toraskar, Martín López‐Vidal, Ziv Porat, Inna Goliand, Ekaterina Petrovich‐Kopitman, Noga Kozer, Haim Michael Barr, Alla H. Falkovich, Leila Motiei, David Margulies   +11 more
wiley   +1 more source

Visualization of membrane-stabilized SorCS2 <i>cis</i> interactions. [PDF]

J Struct Biol X
Beugelink JW, Janssen BJC.
europepmc   +1 more source

Fluxional Monomers Remodel Crystallinity at Low Loadings in Diketopyrrolopyrrole Co‐Thienothiophene Conjugated Polymers

Angewandte Chemie, EarlyView.
Bullvalene is a fluxional molecule capable of adopting numerous conformations spontaneously; just like a Rubik's Cube. In this paper, we explore the incorporation of bullvalene into the backbone of a highly rigid conjugated polymer semiconductor and observe that the inherent fluxionality reduces average crystallite size.
Shine H. Huang, Peiguan B. Sun, Gopal Singh, Matthew J. Elardo, Abraham Herzog‐Arbeitman, Timothy L. Kelly, Matthew R. Golder, Helen Tran   +7 more
wiley   +1 more source

Kinetically Stable Boron-Heteroatom Bonds. [PDF]

Angew Chem Int Ed Engl
Trofimova A, Huang BZ, Soor HS, White B, Holownia A, Lebedev Y, Lough AJ, Dudding T, Yudin AK.   +8 more
europepmc   +1 more source

Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation

Angewandte Chemie, EarlyView.
Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source

Programmable DNA-Based Dimerization Networks for Dynamic and Competitive Control of Transcription. [PDF]

J Am Chem Soc
Quattrociocchi M, Brannetti S, Grosso ED, Ricci F.   +3 more
europepmc   +1 more source

A Precision‐Delivered Singlet Oxygen Generator With an Inbuilt Safety Switch for Induction of Pancreatic Beta Cell Stress and Death

Angewandte Chemie, EarlyView.
ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann, Owen Bendor‐Samuel, Christopher Carlein, Kaja Rupar, Leticia Prates Roma, Ramona Birke, Tolga Soykan, Ingo Breng, Andreas Oder, Iona Davies, Ben Jones, Alice Adriaenssens, Michelle M. Martinez Irizarry, Rachael Morara, Martin Lehmann, Amelia K. Linnemann, David J. Hodson, Johannes Broichhagen   +17 more
wiley   +1 more source

Convergent Synthesis of a Bifunctional GPI as a Universal Platform to Access Diverse GPI and GPI-Anchored Protein Probes. [PDF]

Org Lett
Yan X, Rohokale R, Guo Z.
europepmc   +1 more source

Functionalization and Metal Ion Encapsulation Within a Triaxial Supramolecular Weave

Angewandte Chemie, EarlyView.
The functionalization of a triaxially woven supramolecular weave was achieved. Pre‐assembly modification of the peptide‐perylene monoimide building block enabled facile and homogeneous introduction of acetyl, pivaloyl and thiophene moieties throughout the assembly without disrupting the woven structure.
Andreas Herdlitschka, Tatiana Da Silva‐Ferreira, Joseph F. Woods, Man Him Chak, Elisabeth Engelsberger, Bartosz Lewandowski, Helma Wennemers   +6 more
wiley   +1 more source