Results 141 to 150 of about 25,600 (309)

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

open access: yesAdvanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He   +15 more
wiley   +1 more source

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu   +15 more
wiley   +1 more source

ACTIONS OF SODIUM AZIDE [PDF]

open access: yesBritish Journal of Pharmacology and Chemotherapy, 1949
openaire   +4 more sources

Starch Acetate Grafted to MXene Composite Surpasses Room Temperature Liquid Electrolyte Performance for All‐Solid‐State Lithium‐Ion Batteries

open access: yesAdvanced Science, EarlyView.
By leveraging click chemistry, starch acetate is integrated with MXene quantum dots (MX‐QDs). While the composite electrolyte is electrically insulating, MXene stabilizes the anionic species while acting as a filler to boost mechanical properties. Optimized composition exhibits exceptional ionic conductivity of 14.8 mS cm−1, lithium cation transfer ...
Saeed Hadad   +5 more
wiley   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

open access: yesAdvanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves   +17 more
wiley   +1 more source

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