Results 161 to 170 of about 18,930 (288)

A 3D Multitask Graph Neural Network Framework for Ames Mutagenicity Prediction

Advanced Intelligent Discovery, EarlyView.
Our proposed multitask graph neural network model has a high predictive accuracy for Ames mutagenicity. By operating directly on molecular graph representations instead of traditional molecular descriptors, and predicting strain‐specific results, the model outperforms most existing benchmarks.
Abigail E. Teitgen, Eugenia Ulzurrun, Nuria E. Campillo, Eduardo R. Hernández   +3 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology

Annals of Neurology, EarlyView.
Objective Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri‐synaptic astrocyte process (PAP) defects in human SMA
Emily Welby, Xiaojie Liu, Melinda Wojtkiewicz, Linda Berg Luecke, Rebekah L. Gundry, Qing‐Song Liu, Allison D. Ebert   +6 more
wiley   +1 more source

Intramolecular C-H amination with sulfonyl azides

, 2011
Cobalt (II) complexes of porphyrins are effective catalysts for intramolecular nitrene insertion of C—H bonds with arylsulfonyl azides. The cobalt-catalyzed process can proceed efficiently under mild and neutral conditions in low catalyst loading without
Ruppel, Joshua V., Zhang, X. Peter
core  

A Role for Janus Cyclohexyl Ring Motifs in Medicinal Chemistry. Incorporation Into G-Quadruplex Ligands and Anti-Trypanosoma brucei Activity. [PDF]

Chembiochem
Stewart JM, Kehler M, Kuodis V, Parkinson GN, Chen W, Smith TK, Waller ZAE, O'Hagan D.   +7 more
europepmc   +1 more source

Molecular Glue Degraders of TEM β‐Lactamases by Periplasmic Protease DegP

Angewandte Chemie, EarlyView.
Molecular glues are developed that target TEM‐family β‐lactamases to the bacterial protease DegP for degradation. β‐Lactamase inhibitor tazobactam is identified as accelerating TEM β‐lactamase degradation by DegP, which is further enhanced by linkerless incorporation of dipeptides enriched among DegP substrates.
Emilia K. Taylor, Patricia Santos Barbosa, Tarini Kadambi, Frederik Eisele, Yiqiao Wang, Elisabete C. C. M. Moura, Timothy R. Walsh, Georgia L. Isom, Thomas Lanyon‐Hogg   +8 more
wiley   +2 more sources

Kinetically Stable Boron-Heteroatom Bonds. [PDF]

Angew Chem Int Ed Engl
Trofimova A, Huang BZ, Soor HS, White B, Holownia A, Lebedev Y, Lough AJ, Dudding T, Yudin AK.   +8 more
europepmc   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

A sulfinate-azide hybrid reagent for sequential radical fluoroalkylation and click reaction. [PDF]

Chem Sci
Halkarni P, Ziabko M, Vrábelová V, Opelka M, Qianfei Y, Bi X, Suikov S, Pospíšil P, David T, Boháčová S, Klepetářová B, Beier P.   +11 more
europepmc   +1 more source

Ligand‐Directed Molecular Beacons as Turn‐On Fluorescent Probes for Sensing Cell‐Surface Receptor‐Ligand Interactions

Angewandte Chemie, EarlyView.
Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low, Denis Shpalter, Suraj Toraskar, Martín López‐Vidal, Ziv Porat, Inna Goliand, Ekaterina Petrovich‐Kopitman, Noga Kozer, Haim Michael Barr, Alla H. Falkovich, Leila Motiei, David Margulies   +11 more
wiley   +2 more sources