Results 171 to 180 of about 18,930 (288)

Photochemical C4-Selective C-H Amination of Quinolines via <i>N</i>-Shift of Heteroaryl Azides. [PDF]

Org Lett
Dimasi A, Montoli A, Macetti G, Lo Presti L, Passarella D, Fasano V.   +5 more
europepmc   +1 more source

Fluxional Monomers Remodel Crystallinity at Low Loadings in Diketopyrrolopyrrole Co‐Thienothiophene Conjugated Polymers

Angewandte Chemie, EarlyView.
Bullvalene is a fluxional molecule capable of adopting numerous conformations spontaneously; just like a Rubik's Cube. In this paper, we explore the incorporation of bullvalene into the backbone of a highly rigid conjugated polymer semiconductor and observe that the inherent fluxionality reduces average crystallite size.
Shine H. Huang, Peiguan B. Sun, Gopal Singh, Matthew J. Elardo, Abraham Herzog‐Arbeitman, Timothy L. Kelly, Matthew R. Golder, Helen Tran   +7 more
wiley   +2 more sources

A Water-Soluble Fluorogenic Probe to Quantify Azide Concentrations in Biologically Relevant Environments. [PDF]

Biomacromolecules
Gerrits L, Verdellen L, Peeters M, Gelderman A, Gross UJ, Shaghaghi B, Hammink R, Kouwer PHJ.   +7 more
europepmc   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Beyond traditional strain-promoted azide-alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides. [PDF]

Commun Chem
Tomčo M, Šlachtová V, Vrábel M, Li J, Filgas J, Slavíček P, Bednárová L, Filandr F, Beier P.   +8 more
europepmc   +1 more source

A Precision‐Delivered Singlet Oxygen Generator With an Inbuilt Safety Switch for Induction of Pancreatic Beta Cell Stress and Death

Angewandte Chemie, EarlyView.
ROXendin668 is a peptidic GLP‐1 receptor agonist that generates toxic singlet oxygen upon irradiation with far‐red light. Pancreatic beta cells can be photo‐ablated in a spatiotemporally controlled manner. This approach has the potential to provide a safer alternative to streptozotocin or alloxan for creating model systems for type 1 diabetes research.
Kilian Roßmann, Owen Bendor‐Samuel, Christopher Carlein, Kaja Rupar, Leticia Prates Roma, Ramona Birke, Tolga Soykan, Ingo Breng, Andreas Oder, Iona Davies, Ben Jones, Alice Adriaenssens, Michelle M. Martinez Irizarry, Rachael Morara, Martin Lehmann, Amelia K. Linnemann, David J. Hodson, Johannes Broichhagen   +17 more
wiley   +2 more sources

A Chemical Framework for Engineering Extracellular Vesicles' Biointerface to Advance Precision Therapeutics. [PDF]

Adv Mater
Pourtalebi Jahromi L, Geng F, Frenzke JN, Fuhrmann G.   +3 more
europepmc   +1 more source

Functionalization and Metal Ion Encapsulation Within a Triaxial Supramolecular Weave

Angewandte Chemie, EarlyView.
The functionalization of a triaxially woven supramolecular weave was achieved. Pre‐assembly modification of the peptide‐perylene monoimide building block enabled facile and homogeneous introduction of acetyl, pivaloyl and thiophene moieties throughout the assembly without disrupting the woven structure.
Andreas Herdlitschka, Tatiana Da Silva‐Ferreira, Joseph F. Woods, Man Him Chak, Elisabeth Engelsberger, Bartosz Lewandowski, Helma Wennemers   +6 more
wiley   +2 more sources

Peptide Thioester and Triazole Derivatives Through On-Resin Dual-Modification of Peptide Thiosulfonates. [PDF]

Angew Chem Int Ed Engl
Werner M, Bergmann A, Liu C, Behnam M, Klein C, Thomas F.   +5 more
europepmc   +1 more source

Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation

Angewandte Chemie, EarlyView.
Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source