Results 171 to 180 of about 9,434 (258)

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +1 more source

Development of an On-DNA Platform Molecule Bearing a Diazidestructure and Its Application to DEL Synthesis. [PDF]

Int J Mol Sci
Miyachi H, Koshimizu M, Ratanasak M, Shigeta Y, Suzuki M.   +4 more
europepmc   +1 more source

Force‐Induced Control of Circularly Polarized Luminescence With Rotaxane Architecture

Angewandte Chemie, EarlyView.
Force‐induced reversible on/off switching of circularly polarized luminescence is achieved with a rotaxane‐based supramolecular mechanophore. The mechanophore, featuring a chiral helicene luminophore, is incorporated as a first network cross‐linker into a double‐network organogel.
Keigo Nonaka, Takumi Kuroda, Kota Masuda, Toshiki Nishitani, Masaki Enokido, Makoto Tsurui, Yuichi Kitagawa, Yasuchika Hasegawa, Keiichi Noguchi, Koji Nakano, Yoshimitsu Sagara   +10 more
wiley   +1 more source

Reactivity of 2<i>H</i>-Azirines in Copper-Catalyzed Azide-Alkyne Cycloaddition Reactions. [PDF]

Org Lett
Janecký L, Madabeni A, Jelínková E, Klepetářová B, Rulíšek L, Beier P.   +5 more
europepmc   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +1 more source

Photoactive Iminobismuthanes for Catalytic C-H Amination. [PDF]

J Am Chem Soc
Tsuruta T, Moon HW, Leutzsch M, Williams BA, Spinnato D, Maray-Antolín R, Ullman A, Cornella J.   +7 more
europepmc   +1 more source

π‐Extended COUPY Fluorophores for Targeted Near‐Infrared Fluorescence and Lifetime Imaging in Live Cells

Angewandte Chemie, EarlyView.
π‐Extended COUPY dyes, obtained by vinylogation of coumarin‐based COUPY scaffolds, shift absorption, and emission deep into the NIR region while preserving compactness and synthetic accessibility. These bright, photostable dyes enable live‐cell imaging, FLIM, and site‐specific peptide conjugation, offering a modular platform for targeted bioimaging and
Diego Abad‐Montero, Manel Bosch, Rodrigo Garcés‐Castellanos, Michael Q. Schottenhamel, Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Justo P. Castaño, Tania García‐Becerra, Elena Rebollo, Marta E. Alberto, Antonio Francés‐Monerris, Vicente Marchán   +11 more
wiley   +1 more source

A photochemical strategy for aromatic nitrogen <i>ortho</i>-isomerization. [PDF]

Chem Sci
Lenardon G, Yzeiri X, Le Berre G, Yildiz DB, Leonori D, Ruffoni A.   +5 more
europepmc   +1 more source

Functional and Network PHAs via Stereoselective Polymerization and Tailored Post‐Transformation

Angewandte Chemie, EarlyView.
Catalyst‐controlled stereoselective (co)polymerization of functionalized lactones produces vinyl‐, allyl‐, and propargyl‐functionalized PHAs with high syndiotacticity and a broad applicable temperature window, which can be further transformed into crosslinked PHA thermosets, elastic supramolecular networks, and functional grafts. ABSTRACT Incorporation
Ruirui Li, Yingluo Zhao, Jun‐Jie Tian, Ethan C. Quinn, Yunpeng Gao, Maëlle T. Gace, Eugene Y.‐X. Chen   +6 more
wiley   +1 more source

Development of an <i>In Vitro</i> Assay for Evaluation of Intracellular SPAAC Reactions Using Hoechst-DBCO. [PDF]

Chem Biomed Imaging
Kovacs L, Savela R, Matovic J, Auchynnikava T, Ekholm FS, Airaksinen AJ.   +5 more
europepmc   +1 more source