Results 171 to 180 of about 29,936 (297)

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

High-valent sulfur fluorides as reactivity switches for PFAS-free benzene-azepine skeletal editing. [PDF]

Chem Sci
Nagababu C, Muramatsu T, Bacho MZ, Wu S, Ochiai S, Escorihuela J, Shibata N.   +6 more
europepmc   +1 more source

Enantioselective Radical Dearomative Conjugate Amination Enabled by Co(II)-Based Metalloradical Catalysis. [PDF]

Nat Catal
Xu P, Wang DS, Zhu Z, Zhang XP.
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

Development of an On-DNA Platform Molecule Bearing a Diazidestructure and Its Application to DEL Synthesis. [PDF]

Int J Mol Sci
Miyachi H, Koshimizu M, Ratanasak M, Shigeta Y, Suzuki M.   +4 more
europepmc   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, EarlyView.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

A photochemical strategy for aromatic nitrogen <i>ortho</i>-isomerization. [PDF]

Chem Sci
Lenardon G, Yzeiri X, Le Berre G, Yildiz DB, Leonori D, Ruffoni A.   +5 more
europepmc   +1 more source

Reactivity of 2<i>H</i>-Azirines in Copper-Catalyzed Azide-Alkyne Cycloaddition Reactions. [PDF]

Org Lett
Janecký L, Madabeni A, Jelínková E, Klepetářová B, Rulíšek L, Beier P.   +5 more
europepmc   +1 more source

Enzymatic Synthesis of Mixed XNA Polymers Containing 2'Fluoro and 2'Azide Modifications. [PDF]

ACS Omega
Kang HE, Venkatesh A, Liu SC, Leconte AM.   +3 more
europepmc   +1 more source

Synthesis of 1-Fluoroalkyl-5-Substituted-1,2,3-Triazoles from Carbonyl-Stabilized Phosphonium Ylides. [PDF]

J Org Chem
Tichý D, Černý T, Filgas J, Voltrová S, Klepetářová B, Beier P.   +5 more
europepmc   +1 more source