Results 261 to 270 of about 45,965 (323)

Silicon‐Based Azo Compound‐Mediated CO Activation and N2 Release

open access: yesAngewandte Chemie, EarlyView.
A rare silicon(IV)‐based azo compound featuring a Si─N═N─Si linkage was synthesized via the direct reaction of an organoazide with a silaiminyl–silylene precursor. This compound undergoes an unusual CO activation process, resulting in N2 release and complete cleavage of the C≡O bond, forming a Si(II)/Si(IV) product bridged by an oxygen atom and an ...
Da Jin   +3 more
wiley   +1 more source

Click-Triggered Bioorthogonal Bond-Cleavage Reactions. [PDF]

open access: yesTop Curr Chem (Cham)
Keppel P, Hecko S, Mikula H.
europepmc   +1 more source

Modular Synthesis of Pyritide‐Inspired Macrocycles Featuring Bipyridine Motifs

open access: yesAngewandte Chemie, EarlyView.
A pyritide‐inspired build/couple/pair strategy yields a diverse macrocycle library. This approach expands chemical space and enables the discovery of 6paW, a potent anti‐ferroptotic agent. Abstract Macrocycles represent a promising class of drug‐like scaffolds with unique structural features and the ability to engage challenging targets such as protein–
Ji Hyae Lee   +4 more
wiley   +1 more source

A Broadly Applicable Strategy to Aminate Azines Enabled by Electronically Tuned Phosphine Reagents

open access: yesAngewandte Chemie International Edition, EarlyView.
We have developed a pyridine C4‐amination reaction via phosphonium salt intermediates, where an electronically tuned phosphine is key to successful C─N bond formation. The process accommodates aliphatic amines, (heteroaryl)anilines, hydrazines, and nitrogen heteroaromatics, as well as a variety of pyridine building blocks and late‐stage C─N couplings ...
Ren‐Rong Liu   +2 more
wiley   +1 more source

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