Results 41 to 50 of about 43,569 (363)
Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question [PDF]
, 2021 Micrometer-sized objects are widely known to exhibit chemically-driven motility in systems away from equilibrium. Experimental observation of reaction-induced motility or enhancement in diffusivity at the much shorter length scale of small molecules is however still a matter of debate.
arxiv +1 more source
Chemoselectivity of Tertiary Azides in Strain‐Promoted Alkyne‐Azide Cycloadditions [PDF]
Chemistry – A European Journal, 2018 AbstractThe strain‐promoted alkyne‐azide cycloaddition (SPAAC) is the most commonly employed bioorthogonal reaction with applications in a broad range of fields. Over the years, several different cyclooctyne derivatives have been developed and investigated in regard to their reactivity in SPAAC reactions with azides.
Hannes Mikula +6 more
openaire +6 more sources
Triazol-substituted titanocenes by strain-driven 1,3-dipolar cycloadditions
Beilstein Journal of Organic Chemistry, 2014 An operationally simple, convenient, and mild strategy for the synthesis of triazole-substituted titanocenes via strain-driven 1,3-dipolar cycloadditions between azide-functionalized titanocenes and cyclooctyne has been developed.
Andreas Gansäuer +5 more
doaj +1 more source
Molecules, 2019 Difficult-to-access 4-bromo quinolines are constructed directly from easily prepared ortho-propynol phenyl azides using TMSBr as acid-promoter. The cascade transformation performs smoothly to generate desired products in moderate to excellent yields with
Fengyan Jin +6 more
doaj +1 more source
Machine learning-guided computational screening of new bio-orthogonal click reactions [PDF]
arXiv, 2022 Bio-orthogonal click chemistry has become an indispensable part of the biochemist's toolbox. Despite the wide variety of applications that have been developed in recent years, only a limited number of bio-orthogonal click reactions have been discovered so far, most of them based on (substituted) azides. In this work, we present a computational workflow
arxiv
Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]
, 2012 In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F +6 more
core +1 more source
Solid-phase enrichment and analysis of electrophilic natural products
Beilstein Journal of Organic Chemistry, 2017 In search for new natural products, which may lead to the development of new drugs for all kind of applications, novel methods are needed. Here we describe the identification of electrophilic natural products in crude extracts via their reactivity ...
Frank Wesche, Yue He, Helge B. Bode
doaj +1 more source
One pot ‘click’ reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition [PDF]
, 2010 Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.
Campbell-Verduyn, Lachlan S., +6 more
core +2 more sources
Molecules, 2022 Novel 1,2,3-triazolo-linked-1,5-benzodiazepinones were designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction (CuAAC).
Asma Nsira +5 more
doaj +1 more source
Folding of a donor–acceptor polyrotaxane by using noncovalent bonding interactions [PDF]
, 2008 Mechanically interlocked compounds, such as bistable catenanes and bistable rotaxanes, have been used to bring about actuation in nanoelectromechanical systems (NEMS) and molecular electronic devices (MEDs).
A. Z. Stieg +26 more
core +3 more sources