Results 61 to 70 of about 1,129 (187)

FORMULATION AND IN VITRO EVALUATION OF AZILSARTAN MEDOXOMIL NANOSUSPENSION

International Journal of Pharmacy and Pharmaceutical Sciences, 2017
Objective: The objective of this study was to formulate and evaluate of the poorly soluble drug, azilsartan medoxomil into nanosuspension to increase the solubility and enhance the dissolution rate and then improve its bioavailability.Methods: Nanosuspension of azilsartan medoxomil was prepared using solvent-antisolvent precipitation method using PVP ...
Nizar Awish Jassem, Nawal Ayash Rajab
openaire   +2 more sources

Association between chronic diseases and severe periodontal disease progression: A retrospective cohort study in a city of Japan

Journal of General and Family Medicine, Volume 26, Issue 1, Page 54-64, January 2025.
This manuscript is a study demonstrating the association between the progression of severe periodontal diseases and chronic diseases commonly addressed in primary care. We used claims data and defined the outcome as the “progression of severe periodontitis” and followed patients for 4 years.
Sayaka Nin, Yu Sun, Takami Maeno, Chihiro Nishiura, Kento Taira, Kenji Fujimoto, Jun Hamano, Sachiko Ozone, Tetsuhiro Maeno   +8 more
wiley   +1 more source

Formulations of Amlodipine: A Review

Journal of Pharmaceutics, Volume 2016, Issue 1, 2016., 2016
Amlodipine (AD) is a calcium channel blocker that is mainly used in the treatment of hypertension and angina. However, latest findings have revealed that its efficacy is not only limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant activity and plays an important role in apoptosis. Therefore, it is also employed in
Muhammad Ali Sheraz, Syed Furqan Ahsan, Marium Fatima Khan, Sofia Ahmed, Iqbal Ahmad, Francisco Javier Flores-Murrieta   +5 more
wiley   +1 more source

Rationale and Design of a Randomized, Open‐Label, Parallel‐Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calcium Channel Blocker Monotherapy (ESCORT‐HT)

The Journal of Clinical Hypertension, Volume 27, Issue 1, January 2025.
ABSTRACT Angiotensin II receptor blockers (ARBs) and calcium channel blockers (CCBs) are commonly prescribed as first‐ and second‐line treatments for older Japanese patients with hypertension. However, due to age‐related decline in renin activity, the effectiveness of ARBs may decrease.
Kazuomi Kario, Tomohiro Katsuya, Tatsuo Shimosawa, Takashi Taguchi, Ayumi Tanabe, Mitsuru Ohishi, the ESCORT‐HT investigators   +6 more
wiley   +1 more source

Development and Validation of RP‐HPLC Method for Azilsartan Medoxomil Potassium Quantitation in Human Plasma by Solid Phase Extraction Procedure

International Scholarly Research Notices, Volume 2013, Issue 1, 2013., 2013
Simple and rapid reverse phase high‐performance liquid chromatography (RP‐HPLC) method was developed and validated using solid phase extraction (SPE) technique for the determination of Azilsartan Medoxomil Potassium (AMP) in human plasma; detection was carried out by photo diode array detector. Chromatographic separation of the analyte AMP was achieved
Paras P. Vekariya, Hitendra S. Joshi, I. P. Gerothanassis, B. Liu, S. Pandey   +4 more
wiley   +1 more source

Discovery of Inhibitors of Insulin‐Regulated Aminopeptidase as Cognitive Enhancers

International Journal of Hypertension, Volume 2012, Issue 1, 2012., 2012
The hexapeptide angiotensin IV (Ang IV) is a metabolite of angiotensin II (Ang II) and plays a central role in the brain. It was reported more than two decades ago that intracerebroventricular injection of Ang IV improved memory and learning in the rat.
Hanna Andersson, Mathias Hallberg, Patrick Vanderheyden   +2 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AZILSARTAN MEDOXOMIL AND CHLORTHALIDONE IN BULK AND TABLET DOSAGE FORM [PDF]

, 2018
Objective: A simple, precise, accurate method was developed for the simultaneous estimation of azilsartan and chlorthalidone in bulk and tablet dosage form by RP-HPLC technique.Methods: Acetonitrile and water in the ratio of (70:30) pH 2.8 used as mobile
Aher, S. S., Kothari, Hemant, Saudagar, R. B.   +2 more
core   +1 more source

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AZILSARTAN MEDOXIMIL AND CHLORTHALIDONE IN BULK FORM AND FORMULATION USING QUALITY BY DESIGN [PDF]

, 2016
Objective: Development of an accurate, precise, robust, sensitive, economical and rapid isocratic reversed-phase high-performance liquid chromatography (RP-HPLC) method complying quality by design (QbD) trends for simultaneous estimation of azilsartan ...
Akhtar, Mymoona, Chawla, Gita, Kumar, Robin, Ranjan, Chanda, Sohni, Sandeep Kumar   +4 more
core   +1 more source

Quantitative Estimation and Validation of Chlorthlidone and Azilsartan Medoximil in Bulk and Tablet Dosage Form by using RP-HPLC [PDF]

, 2019
The first reversed phase high performance liquid chromatographic method for Stability Indicating of, Azilsartan and chlorthalidone has been developed and validated to be a simple, sensitive, rapid, specific, precise, and accurate method.
Dhamak, Kavita V, Dighe, Nachiket S., Shinde, Ganesh S, Thorat, Somnath K.   +3 more
core   +2 more sources

Modern approaches to the treatment and long-term management of arterial hypertension in clinical practice. Pharmacological and clinical characteristics of angiotensin II receptor blockers: focus on azilsartan medoxomil. Part I

КардиоСоматика, 2015
This article deals withthe overview of the pharmacological characteristics of one class of antihypertensive drugs - angiotensin II receptor antagonists (ARA II) and new member of this class - azilsartan medoxomil (Edarbi®).We have analyzed the ...
M. G Bubnova
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