Design‐Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm‐Partial Least Squares Models [PDF]
Analytical Science AdvancesThis study presents a sustainable chemometric‐assisted UV spectrophotometric strategy for the simultaneous determination of candesartan cilexetil (CAN), chlorthalidone (CTL) and amlodipine (AML) in laboratory‐prepared mixtures and commercial ...
Khanda F. M. Amin +3 more
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Optimizing Blood Pressure Control: A Randomized Comparative Trial of Losartan/Chlorthalidone vs. Losartan/Hydrochlorothiazide [PDF]
Cardiology and TherapyIntroduction Cardiovascular diseases are a leading cause of global mortality, with hypertension as a major risk factor. Low control rates are often attributed to monotherapy, while evidence and clinical guidelines support the effectiveness of combination
Isabel E. Rucker-Joerg +8 more
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Hydrochlorothiazide and chlorthalidone use and glaucoma risk: pharmacovigilance analysis and nationwide cohort study [PDF]
Frontiers in PharmacologyHydrochlorothiazide and chlorthalidone are widely used thiazide diuretics, and pharmacovigilance reports have suggested a possible link between their use and glaucoma.
Jooyoung Yoon +4 more
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Per‐Protocol Analysis of Chlorthalidone Versus Hydrochlorothiazide for Cardiovascular Event Prevention—Diuretic Comparison Project [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground The DCP (Diuretic Comparison Project), a pragmatic trial, evaluated whether chlorthalidone compared with hydrochlorothiazide would reduce the risk of nonfatal cardiovascular disease or noncancer‐related death.
Sonia T. Anand +9 more
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Development and validation of UV Spectrophotometric method for simultaneous estimation of Efonidipine hydrochloride ethanolate and Chlorthalidone in their synthetic mixture [PDF]
Drug Analytical Research, 2022 Efonidipine Hydrochloride Ethanolate and Chlorthalidone is used in management of hypertension and under clinical phase 3 study. The development of quality control method is required for accurate analysis of both drugs. Two simple, precise and economical
Dipika Solanki +2 more
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Minimally Symptomatic Severe Hyponatremia: Two Case Reports [PDF]
Clinical Practice and Cases in Emergency MedicineIntroduction: Hyponatremia is a common and often vexing electrolyte abnormality seen in the emergency setting. The severity of a patient’s symptoms is often dictated by the acuity of hyponatremia development and degree of serum sodium deficit, with ...
Jordan Richardson +2 more
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Pharmaceutics, 2022 A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis.
Christian Rodríguez-Ruiz +2 more
exaly +3 more sources
Stability Indicating Method to Analyze Benidipine and Chlorthalidone Using HPLC Technique: Establishment, Validation and Application to Tablets [PDF]
Pharmaceutical Sciences, 2020 Background: The combination of chlorthalidone and benidipine was used to manage hypertension. The mixture of chlorthalidone and benidipine in tablet dosage form has not been previously determined by any method.
Kadali Jagadeesh, Nowduri Annapurna
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Hydrochlorothiazide Is America's Most Popular Thiazide, But Should It Be? [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseasePeter S. Natov, Amy R. Schwartz
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Diuretics for hypertension from the perspective of novel clinical guidelines and meta-analyzes
Российский кардиологический журнал, 2021 A review of the efficacy and safety of diuretics in hypertension was carried out from the standpoint of current clinical guidelines. Also, updated data from metaanalyzes of the efficacy and metabolic effects of diuretic therapy were reviewed.
S. V. Nedogoda
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