Results 1 to 10 of about 214 (128)

Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal

Pharmaceutics, 2022
A cocrystal of the antihypertensive drug chlorthalidone (CTD) with caffeine (CAF) was obtained (CTD-CAF) by the slurry method, for which a 2:1 stoichiometric ratio was found by powder and single-crystal X-ray diffraction analysis.
Christian Rodríguez-Ruiz, Herbert Höpfl, Jorge Guillermo Domínguez-Chávez   +2 more
exaly   +3 more sources

Design‐Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm‐Partial Least Squares Models

Analytical Science Advances
This study presents a sustainable chemometric‐assisted UV spectrophotometric strategy for the simultaneous determination of candesartan cilexetil (CAN), chlorthalidone (CTL) and amlodipine (AML) in laboratory‐prepared mixtures and commercial ...
Khanda F. M. Amin, Samar H. Elagamy, Reem H. Obaydo, Hayam M. Lotfy   +3 more
doaj   +2 more sources

Stability Indicating Method to Analyze Benidipine and Chlorthalidone Using HPLC Technique: Establishment, Validation and Application to Tablets [PDF]

Pharmaceutical Sciences, 2020
Background: The combination of chlorthalidone and benidipine was used to manage hypertension. The mixture of chlorthalidone and benidipine in tablet dosage form has not been previously determined by any method.
Kadali Jagadeesh, Nowduri Annapurna
doaj   +1 more source

Development and validation of UV Spectrophotometric method for simultaneous estimation of Efonidipine hydrochloride ethanolate and Chlorthalidone in their synthetic mixture

Drug Analytical Research, 2022
Efonidipine Hydrochloride Ethanolate and Chlorthalidone is used in management of hypertension and under clinical phase 3 study. The development of quality control method is required for accurate analysis of both drugs. Two simple, precise and economical
Dipika Solanki, Dhara Patel, Dhananjay Meshram   +2 more
doaj   +1 more source

Diuretics for hypertension from the perspective of novel clinical guidelines and meta-analyzes

Российский кардиологический журнал, 2021
A review of the efficacy and safety of diuretics in hypertension was carried out from the standpoint of current clinical guidelines. Also, updated data from metaanalyzes of the efficacy and metabolic effects of diuretic therapy were reviewed.
S. V. Nedogoda
doaj   +1 more source

Exploration of 1, 2-naphthoquinone-4-sulfonate derivatizing reagent for determination of chlorthalidone in tablets: a spectrophotometric investigation

Future Journal of Pharmaceutical Sciences, 2021
Background Chlorthalidone is a diuretic medicinal agent used to treat hypertension. Lowering hypertension results in the prevention of strokes, heart attacks and kidney-related problems.
Suraj R. Chaudhari, Atul A. Shirkhedkar
doaj   +1 more source

Rational pharmacotherapy of arterial hypertension in real clinical practice: diuretics through drug safety

Клинический разбор в общей медицине, 2023
The use of diuretics in arterial hypertension is pathogenetically justified, which is due to the significant role of an increase in the volume of circulating blood and the retention of sodium ions in the internal environment of the body, in increasing ...
Dmitry I. Trukhan, Natalya V. Bagisheva   +1 more
doaj   +1 more source

All diuretics used in the treatment of hypertension are not the same

Türk Kardiyoloji Derneği Arşivi, 2017
Summary– Diuretics have been used for years to treat hypertension as both a monotherapy and in combination. Hydrochlorothiazide, indapamide, and chlorthalidone have frequently been considered in the same category as thiazide diuretics, but there is no ...
Serkan Asil, Enver Atalar
doaj   +1 more source

Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patients with hypertension and coronary artery disease

Arquivos Brasileiros de Cardiologia, 2001
OBJETIVE: Antihypertensive therapy with thiazides decreases coronary events in elderly patients. However, the influence of diuretics on myocardial ischemia has not been fully investigated. The aim of this study was to compare the effect of chlorthalidone
João Batista Serro-Azul, Rogério Silva de Paula, César Gruppi, Lígia Pinto, Humberto Pierri, Amit Nussbacher, Otávio Gebara, Paulo Moffa, Antônio Carlos Pereira-Barreto, Maurício Wajngarten   +9 more
doaj   +1 more source

Efficacy and safety of standard dose triple combination of telmisartan 80 mg/amlodipine 5 mg/chlorthalidone 25 mg in primary hypertension: A randomized, double‐blind, active‐controlled, multicenter phase 3 trial

The Journal of Clinical Hypertension, 2023
The authors evaluated the efficacy, safety, and characteristics of patients who respond well to standard dose triple combination therapy including chlorthalidone 25 mg with telmisartan 80 mg plus amlodipine 5 mg in hypertensive patients.
Eun Joo Cho, Moo Hyun Kim, Young‐Hak Kim, Kiyuk Chang, Dong‐Ju Choi, Woong Chol Kang, Jinho Shin, Seong Hwan Kim, Namho Lee, Jang Won Son, Joon‐Hyung Doh, Woo‐Shik Kim, Soon Jun Hong, Moo‐Yong Rhee, Youngkeun Ahn, Sang‐Wook Lim, Seung Pyo Hong, So‐Yeon Choi, Min Su Hyon, Jin‐Yong Hwang, Kihwan Kwon, Kwang Soo Cha, Sang‐Hyun Ihm, Jae‐Hwan Lee, Byung‐Su Yoo, Hyo‐Soo Kim   +25 more
doaj   +1 more source