Results 11 to 20 of about 214 (128)

Environmental benign RP-HPLC method for the simultaneous estimation of anti-hypertensive drugs using analytical quality by design

Green Chemistry Letters and Reviews, 2023
Green analytical procedures replace harmful organic modifiers with green solvents without affecting chromatographic performance, enabling industries and research laboratories to develop green analytical methods.
Naveenarani Dharuman, Karunanidhi Santhana Lakshmi, Manikandan Krishnan   +2 more
doaj   +1 more source

Antihypertensive efficacy of metoprolol XL/Low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in Indian patients with mild-to-moderate essential hypertension

European Journal of Medical Research, 2009
Objective High blood pressure is one of the most important risk factors, directly responsible for increasing the cardiovascular morbidity and mortality. The primary objective was to evaluate the efficacy of metoprolol XL/chlorthalidone against metoprolol
Pareek A, Zawar SD, Salagre SB, Chandurkar NB, Karnik ND   +4 more
doaj   +1 more source

Bilateral, Simultaneous, Acute Angle Closure Glaucoma in Pseudophakia Induced by Chlorthalidone

Case Reports in Ophthalmological Medicine, 2016
Purpose. To report two persons with acute, bilateral, and simultaneous angle closure glaucoma in pseudophakia secondary to uveal effusions induced by administration of chlorthalidone. Methods. Case reports. Results.
Indra Durai, Mrunali Mohan Dhavalikar, Chandran Prem Anand, Venkatraman Ganesh, Ramaswami Krishnadas   +4 more
doaj   +1 more source

Clinical effectiveness and safety of amlodipine/losartan‐based single‐pill combination therapy in patients with hypertension: Findings from real‐world, multicenter observational databases

The Journal of Clinical Hypertension, 2021
Various single‐pill combinations (SPCs) have been introduced to improve drug compliance and clinical efficacy. However, there is a lack of real‐world evidence regarding the effectiveness of these SPCs for hypertension. This study evaluated the real‐world
Jieun Lee, Jaeyun Choi, Yunjin Yum, Hyung Joon Joo, Yong‐Hyun Kim, Hyonggin An, Eung Ju Kim   +6 more
doaj   +1 more source

S-amlodipine plus chlorthalidone vs. S-amlodipine plus telmisartan in hypertensive patients unresponsive to amlodipine monotherapy: study protocol for a randomized controlled trial

Trials, 2018
Background The efficacy of a combination of a calcium channel blocker (CCB) plus chlorthalidone (diuretic) versus a CCB plus an angiotensin receptor blocker (ARB) in patients not responding to CCB monotherapy has not been evaluated previously. We plan to
Sang-Ho Jo, Sung-Ji Park, Eung Ju Kim, Soo-Joong Kim, Hyun-Jae Cho, Jong-Min Song, Jinho Shin, Jin Joo Park, Joon-Han Shin, Kyoo-Rok Han, Dong-Ju Choi   +10 more
doaj   +1 more source

Monotherapy treatment with chlorthalidone or amlodipine in the systolic blood pressure intervention trial (SPRINT)

The Journal of Clinical Hypertension, 2021
This post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) examined the performance of chlorthalidone (C) versus amlodipine (A) monotherapies.
Deep Vakil, Stavros Zinonos, John B. Kostis, Jeanne M. Dobrzynski, Nora M. Cosgrove, Abel E. Moreyra, William J. Kostis   +6 more
doaj   +1 more source

Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThiazide and thiazide‐like diuretics are first‐line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with ...
Sonal Singh, Caitrin W. McDonough, Yan Gong, Wael A. Alghamdi, Meghan J. Arwood, Salma A. Bargal, Leanne Dumeny, Wen‐Yi Li, Mai Mehanna, Bradley Stockard, Guang Yang, Felipe A. de Oliveira, Natalie C. Fredette, Mohamed H. Shahin, Kent R. Bailey, Amber L. Beitelshees, Eric Boerwinkle, Arlene B. Chapman, John G. Gums, Stephen T. Turner, Rhonda M. Cooper‐DeHoff, Julie A. Johnson   +21 more
doaj   +1 more source

The Antihypertensive Efficacy of Chlorthalidone and Telmisartan in Indian Hypertensive Patients who were Uncontrolled with Hydrochlorothiazide and Telmisartan Combination-A Prospective and an Open Label Study [PDF]

Journal of Clinical and Diagnostic Research, 2014
Objective: The primary objective of this study was to evaluate the antihypertensive efficacy of the chlorthalidone and telmisartan combination in Indian hypertensive patients who remained uncontrolled after taking the hydrochlorothiazide and ...
Suresh V Sagarad, Sudha Biradar Kerure, Chaitanya Kumar S, Ramakrishna MR   +3 more
doaj   +1 more source

Validation of Heart Failure Events in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Participants Assigned to Doxazosin and Chlorthalidone

Current Controlled Trials in Cardiovascular Medicine, 2002
Background The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a randomized, double-blind, active-controlled trial designed to compare the rate of coronary heart disease events in high-risk hypertensive ...
Leenen Frans HH, Williamson Jeff D, Wright Jackson T, Cushman William C, Cutler Jeffrey A, Davis Barry R, Piller Linda B, Einhorn Paula T, Randall Otelio S, Golden John S, Haywood L Julian   +10 more
doaj   +1 more source

Hydrochlorothiazide and chlorthalidone use and glaucoma risk: pharmacovigilance analysis and nationwide cohort study

Frontiers in Pharmacology
Hydrochlorothiazide and chlorthalidone are widely used thiazide diuretics, and pharmacovigilance reports have suggested a possible link between their use and glaucoma.
Jooyoung Yoon, Jiyeong Kim, Ko Eun Kim, Jee-Eun Chung, Seong Joon Ahn   +4 more
doaj   +1 more source