Results 31 to 40 of about 4,532 (203)

Clinical effectiveness and safety of amlodipine/losartan‐based single‐pill combination therapy in patients with hypertension: Findings from real‐world, multicenter observational databases

The Journal of Clinical Hypertension, 2021
Various single‐pill combinations (SPCs) have been introduced to improve drug compliance and clinical efficacy. However, there is a lack of real‐world evidence regarding the effectiveness of these SPCs for hypertension. This study evaluated the real‐world
Jieun Lee, Jaeyun Choi, Yunjin Yum, Hyung Joon Joo, Yong‐Hyun Kim, Hyonggin An, Eung Ju Kim   +6 more
doaj   +1 more source

S-amlodipine plus chlorthalidone vs. S-amlodipine plus telmisartan in hypertensive patients unresponsive to amlodipine monotherapy: study protocol for a randomized controlled trial

Trials, 2018
Background The efficacy of a combination of a calcium channel blocker (CCB) plus chlorthalidone (diuretic) versus a CCB plus an angiotensin receptor blocker (ARB) in patients not responding to CCB monotherapy has not been evaluated previously. We plan to
Sang-Ho Jo, Sung-Ji Park, Eung Ju Kim, Soo-Joong Kim, Hyun-Jae Cho, Jong-Min Song, Jinho Shin, Jin Joo Park, Joon-Han Shin, Kyoo-Rok Han, Dong-Ju Choi   +10 more
doaj   +1 more source

Monotherapy treatment with chlorthalidone or amlodipine in the systolic blood pressure intervention trial (SPRINT)

The Journal of Clinical Hypertension, 2021
This post hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) examined the performance of chlorthalidone (C) versus amlodipine (A) monotherapies.
Deep Vakil, Stavros Zinonos, John B. Kostis, Jeanne M. Dobrzynski, Nora M. Cosgrove, Abel E. Moreyra, William J. Kostis   +6 more
doaj   +1 more source

Genome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThiazide and thiazide‐like diuretics are first‐line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with ...
Sonal Singh, Caitrin W. McDonough, Yan Gong, Wael A. Alghamdi, Meghan J. Arwood, Salma A. Bargal, Leanne Dumeny, Wen‐Yi Li, Mai Mehanna, Bradley Stockard, Guang Yang, Felipe A. de Oliveira, Natalie C. Fredette, Mohamed H. Shahin, Kent R. Bailey, Amber L. Beitelshees, Eric Boerwinkle, Arlene B. Chapman, John G. Gums, Stephen T. Turner, Rhonda M. Cooper‐DeHoff, Julie A. Johnson   +21 more
doaj   +1 more source

The Antihypertensive Efficacy of Chlorthalidone and Telmisartan in Indian Hypertensive Patients who were Uncontrolled with Hydrochlorothiazide and Telmisartan Combination-A Prospective and an Open Label Study [PDF]

Journal of Clinical and Diagnostic Research, 2014
Objective: The primary objective of this study was to evaluate the antihypertensive efficacy of the chlorthalidone and telmisartan combination in Indian hypertensive patients who remained uncontrolled after taking the hydrochlorothiazide and ...
Suresh V Sagarad, Sudha Biradar Kerure, Chaitanya Kumar S, Ramakrishna MR   +3 more
doaj   +1 more source

Validation of Heart Failure Events in the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Participants Assigned to Doxazosin and Chlorthalidone

Current Controlled Trials in Cardiovascular Medicine, 2002
Background The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a randomized, double-blind, active-controlled trial designed to compare the rate of coronary heart disease events in high-risk hypertensive ...
Leenen Frans HH, Williamson Jeff D, Wright Jackson T, Cushman William C, Cutler Jeffrey A, Davis Barry R, Piller Linda B, Einhorn Paula T, Randall Otelio S, Golden John S, Haywood L Julian   +10 more
doaj   +1 more source

Effectiveness of Antihypertensive Medications in Office and Ambulatory Settings: A Placebo‐Controlled Comparison of Atenolol, Metoprolol, Chlorthalidone, Verapamil, and an Atenolol‐Chlorthalidone Combination

, 1992
In a double‐blind, crossover study, five white men with mild‐to‐moderate hypertension received placebo and fixed doses of atenolol, metoprolol, chlorthalidone, Verapamil, and the combination of atenolol and chlorthalidone in a quasi‐random order.
Lynn A. Durel, Donald J. Weidler, Schneiderman, Neil, Weidler, Donald J, Peter J. Hayashi, Hayashi, Peter J, Neil Schneiderman, Durel, Lynn A   +7 more
core   +1 more source

Comparative Efficacy of Single Pill Combinations of Azilsartan Medoxomil/Chlorthalidone and Losartan/Hydrochlorothiazide in Patients with Hypertension and Heart Failure with Preserved Ejection Fraction

Рациональная фармакотерапия в кардиологии, 2022
Aim. To study the effects of azilsartan medoxomil/chlorthalidone (AZM/CTD) and losartan/hydrochlorothiazide (LOS/HCT) combinations for NTproBNP levels, 6-minute walk test results, hydration status along with their antihypertensive efficacy according to ...
Zh. D. Kobalava, A. F. Safarova, Kh. M. Gudieva, M. A. Markova, A. E. Petrosyan   +4 more
doaj   +1 more source

Chlorthalidone Decreases Platelet Aggregation and Vascular Permeability and Promotes Angiogenesis

, 2010
Variations in diuretic-mediated inhibition of carbonic anhydrase-dependent chloride transport in platelets and vascular smooth muscle could account for the contrasting efficacy of the thiazide and thiazide-like diuretics in reducing cardiovascular ...
Ryan Woodman, Christina Brown, Warren Lockette   +2 more
core   +1 more source

The comparison between Bumetanide and chlorthalidone and its effect on patients’ high blood pressure

, 2020
© 2020, Advanced Scientific Research. All rights reserved.This research purposes to determine the potential influence of Bumetanide and Chlorthalidone on patients’ high blood pressure.
Abbas, Mohammad, ULUDAĞ, MECİT ORHAN
core   +1 more source