Results 31 to 40 of about 214 (128)

Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form

open access: yesOpen Chemistry, 2021
Five various chemometric methods were established for the simultaneous determination of azilsartan medoxomil (AZM) and chlorthalidone in the presence of azilsartan which is the core impurity of AZM.
Darwish Hany W.   +5 more
doaj   +1 more source

Trajectories of Treatment Disruption for Chronic Outpatient Medications for U.S. Veterans During Drug Shortages

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Introduction Although drug shortages for outpatient chronic conditions commonly occur, population‐level data on how they impact patients' ability to refill prescriptions is scarce. We sought to identify distinct patterns of refill adherence following drug shortages and patient‐ and prescription‐level factors associated with adherence ...
Katie J. Suda   +14 more
wiley   +1 more source

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes   +4 more
wiley   +1 more source

Efficacy and safety of low‐dose antihypertensive combination of amlodipine, telmisartan, and chlorthalidone: A randomized, double‐blind, parallel, phase II trial

open access: yesThe Journal of Clinical Hypertension, 2022
The aim of this clinical trial was to assess the efficacy and safety of low‐dose triple combinations of amlodipine, telmisartan, and chlorthalidone in patients with essential hypertension.
Ki‐Chul Sung   +16 more
doaj   +1 more source

Changes in arterial stiffness under blood pressure control are independently associated with cognitive impairment: The Systolic Blood Pressure Intervention Trial (SPRINT)

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Blood pressure treatment‐related changes in arterial stiffness measures over 3 years and their longitudinal relationships with time to incident cognitive impairment over 10 years in the Systolic Blood Pressure Intervention Trial. Longitudinal progression of systolic blood pressure and pulse wave velocity (PWV) components under intensive versus standard
Timothy M. Hughes   +9 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Modifiable Risk Factors in Atrial Fibrillation: Clinical Implications and Pathophysiological Insights

open access: yesAnnals of Noninvasive Electrocardiology, Volume 31, Issue 2, March 2026.
Modifiable cardiometabolic and lifestyle factors converge on shared atrial mechanisms, including fibrosis, autonomic imbalance, and electrical remodeling, to promote AF initiation and recurrence. Targeting these upstream drivers through structured risk‐factor management enhances rhythm‐control durability and improves long‐term clinical outcomes ...
Chamath Jagoda
wiley   +1 more source

Controlling Selectivity at the First Hydrogenation Level: Synthesis of 3‐Hydroxyisoindolines by Heterogeneously Silver‐Catalyzed Monohydrogenation of Phthalimides

open access: yesAdvanced Science, Volume 13, Issue 2, 9 January 2026.
3‐Hydroxylactams are obtained from phthalimides through a heterogeneous catalyzed chemoselective hydrogenation, able to stop the process at the first hydrogenation level. By using a rationally designed [Ag/Al2O3] recyclable solid nanocatalyst, a wide range of cyclic hemiamidals are accesed through a full atom‐economical reaction that preserves (hetero ...
Carles Lluna‐Galán   +2 more
wiley   +1 more source

Optimizing Blood Pressure Control: A Randomized Comparative Trial of Losartan/Chlorthalidone vs. Losartan/Hydrochlorothiazide

open access: yesCardiology and Therapy
Introduction Cardiovascular diseases are a leading cause of global mortality, with hypertension as a major risk factor. Low control rates are often attributed to monotherapy, while evidence and clinical guidelines support the effectiveness of combination
Isabel E. Rucker-Joerg   +8 more
doaj   +1 more source

Development and Validation of Stability-Indicating Method for Estimation of Chlorthalidone in Bulk and Tablets with the Use of Experimental Design in Forced Degradation Experiments

open access: yesScientifica, 2016
Chlorthalidone was subjected to various forced degradation conditions. Substantial degradation of chlorthalidone was obtained in acid, alkali, and oxidative conditions.
Sandeep Sonawane   +4 more
doaj   +1 more source

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