Results 51 to 60 of about 4,532 (203)

DIURETIC-BASED COMBINATION THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION: RESULTS OF THE RUSSIAN TRUST STUDY

open access: yesКардиоваскулярная терапия и профилактика, 2013
Arterial hypertension (AH) is one of the most important problems of the modern medicine, due to its exceptionally high prevalence. This study focused on effectiveness and safety of the diuretic-based combination therapy among patients aged >18 years ...
N. E. Gavrilova, R. G. Oganov
doaj   +1 more source

Comparison of the antihypertensive activities of xipamide and chlorthalidone: A double-blind, randomized, crossover trial

open access: yes, 1981
The effectiveness of a new potent diuretic, xipamide, was evaluated in the treatment of patients with mild to moderate essential hypertension. The effects of daily doses of 40 mg xipamide were compared with those of 100 mg chlorthalidone with respect to ...
Romango E   +9 more
core   +1 more source

Efficacy and safety of low‐dose antihypertensive combination of amlodipine, telmisartan, and chlorthalidone: A randomized, double‐blind, parallel, phase II trial

open access: yesThe Journal of Clinical Hypertension, 2022
The aim of this clinical trial was to assess the efficacy and safety of low‐dose triple combinations of amlodipine, telmisartan, and chlorthalidone in patients with essential hypertension.
Ki‐Chul Sung   +16 more
doaj   +1 more source

Evaluation of a Point‐of‐Care Viscoelastic Coagulation Monitor (VCM Vet) and Thromboelastography (TEG) in Bonobos (Pan paniscus)

open access: yesJournal of Medical Primatology, Volume 55, Issue 4, August 2026.
ABSTRACT Introduction Bonobos (Pan paniscus) are endangered and uncommon in managed care. Prothrombotic and hypofibrinolytic states are encountered with cardiovascular disease, ischemic stroke, and neoplasia. Materials and Methods Twelve bonobos from one institution were evaluated during anesthetized exams.
Megan M. Roeder   +7 more
wiley   +1 more source

Development and Validation of Stability-Indicating Method for Estimation of Chlorthalidone in Bulk and Tablets with the Use of Experimental Design in Forced Degradation Experiments

open access: yesScientifica, 2016
Chlorthalidone was subjected to various forced degradation conditions. Substantial degradation of chlorthalidone was obtained in acid, alkali, and oxidative conditions.
Sandeep Sonawane   +4 more
doaj   +1 more source

Trajectories of Treatment Disruption for Chronic Outpatient Medications for U.S. Veterans During Drug Shortages

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.
ABSTRACT Introduction Although drug shortages for outpatient chronic conditions commonly occur, population‐level data on how they impact patients' ability to refill prescriptions is scarce. We sought to identify distinct patterns of refill adherence following drug shortages and patient‐ and prescription‐level factors associated with adherence ...
Katie J. Suda   +14 more
wiley   +1 more source

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes   +4 more
wiley   +1 more source

Changes in arterial stiffness under blood pressure control are independently associated with cognitive impairment: The Systolic Blood Pressure Intervention Trial (SPRINT)

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Blood pressure treatment‐related changes in arterial stiffness measures over 3 years and their longitudinal relationships with time to incident cognitive impairment over 10 years in the Systolic Blood Pressure Intervention Trial. Longitudinal progression of systolic blood pressure and pulse wave velocity (PWV) components under intensive versus standard
Timothy M. Hughes   +9 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

Modifiable Risk Factors in Atrial Fibrillation: Clinical Implications and Pathophysiological Insights

open access: yesAnnals of Noninvasive Electrocardiology, Volume 31, Issue 2, March 2026.
Modifiable cardiometabolic and lifestyle factors converge on shared atrial mechanisms, including fibrosis, autonomic imbalance, and electrical remodeling, to promote AF initiation and recurrence. Targeting these upstream drivers through structured risk‐factor management enhances rhythm‐control durability and improves long‐term clinical outcomes ...
Chamath Jagoda
wiley   +1 more source

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