Results 71 to 80 of about 214 (128)
The hyperglycaemic effect of the diuretic chlorthalidone
Journal of Pharmacy and Pharmacology, 1971 openaire +2 more sources
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Chlorthalidone: The Forgotten Diuretic
Postgraduate Medicine, 2012Chlorthalidone's safety and efficacy in the management of hypertension has been demonstrated in landmark trials. Despite understanding the effects of thiazides on urinary sodium excretion and intravascular volume, the exact mechanism of their antihypertensive effects is not clearly understood. Common compensatory mechanisms for decreases in circulating
David S Kountz
exaly +3 more sources
Chlorthalidone Versus Hydrochlorothiazide
Annals of Internal Medicine, 2013TO THE EDITOR: Dhalla and colleagues state, "As typically prescribed, chlorthalidone in older adults was not associated with fewer adverse cardiovascular events or deaths than hydrochlorothiazide. However, it was associated with a greater incidence of electrolyte abnormalities, particularly hypokalemia." This observational cohort study is contrary to a
DiNicolantonio, James J. +2 more
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Chlorthalidone for Hypertension in Advanced CKD
New England Journal of Medicine, 2022To the Editor: Agarwal and colleagues (Dec. 30 issue)(1) report the findings from a trial evaluating the use of chlorthalidone as an antihypertensive agent in patients with advanced chronic kidney disease (CKD) and poorly controlled hypertension.
ELSÜRER AFŞAR, Rengin +2 more
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Automated Analysis of Chlorthalidone
Journal of Pharmaceutical Sciences, 1979Chlorthalidone inhibition of the enzymatic hydrolysis rate of p-nitrophenyl acetate by bovine erythrocyte carbonic anhydrase was used as a basis for chlorthalidone determination in plasma and urine. For urinary samples, a completely automated, continuous flow system was developed to extract the samples and perform the enzymatic reaction.
M M, Johnston, M, Rosenberg, B, Kamath
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Chlorthalidone – a renaissance in use?
Expert Opinion on Pharmacotherapy, 2009Diuretic therapy remains a mainstay of hypertension treatment, either given as monotherapy or used in combination with other antihypertensive compounds. Several issues have complicated the issue of diuretic use with that of class effect being the one that has proven most difficult.
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Metoprolol with and without chlorthalidone in hypertension
Clinical Pharmacology & Therapeutics, 1979After a control period on a placebo, 45 patients with mild to moderate hypertension were treated with metoprolol, 100 mg twice daily alone and in free combination with chlorthalidone 50 mg daily using a double‐blind crossover technique. The β‐blocker alone induced a significant fall in blood pressure; the diastolic pressure was reduced to 100 mg Hg or ...
M, Kubik, M, Kendall, A, Ebbutt, V, John
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Optimization of a Tablet Containing Chlorthalidone
Drug Development and Industrial Pharmacy, 1999In pharmaceutical technological research, optimization studies generally deal with the search for the formulation that is as effective and as functional as possible. The effect of a formulation parameter (the amount of lactose in the composition of the tablets) and of a technological parameter (compression pressure) on four physical characteristics ...
G C, Ceschel, P, Maffei, R, Badiello
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Treatment of Hypoparathyroid Patients with Chlorthalidone
New England Journal of Medicine, 1978In an effort to maintain normal serum calcium levels without inducing hypercalciuria, we treated seven hypoparathyroid patients for up to 25 months with chlorthalidone, a thiazide-like sulfonamide diuretic, plus a salt-restricted diet, without added vitamin D.
R H, Porter +5 more
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