Results 41 to 50 of about 214 (128)

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 220-229, January 2026.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu, Hsien‐Chih Chiu, Ju‐Chieh Wung, Yueh‐Ching Chou, Yuh‐Lih Chang, Chian‐Ying Chou, Chin‐Chou Huang   +6 more
wiley   +1 more source

Differential Effects of Antihypertensive Drug Classes on Home and Office Blood Pressure Variability

International Journal of Hypertension, Volume 2026, Issue 1, 2026.
Objective Blood pressure (BP) variability provides prognostic information beyond mean BP. However, the class‐specific associations of antihypertensive medications with BP variability remain uncertain, and few studies have directly contrasted home and office BP variability within the same patients while accounting for the white‐coat effect. Methods In a
Dong-Hyuk Cho, Mi-Na Kim, Jung-Joon Cha, Se Won Oh, Jae Hyoung Park, Kyung-Hee Cho, Seung Yong Shin, Eung Ju Kim, Hyung Joon Joo, Sreeja Dattachoudhury   +9 more
wiley   +1 more source

A Comprehensive Review on the Efficacy of Antihypertensives in Patients With End‐Stage Renal Disease

International Journal of Hypertension, Volume 2026, Issue 1, 2026.
End‐stage renal disease (ESRD) patients are particularly susceptible to hypertension, as blood pressure (BP) dysregulation leads to increased mortality and morbidity, especially considering the heightened risk of cardiovascular complications, including myocardial infarction, stroke, and congestive heart failure. Given the lack of specific guidelines on
Oluwakorede Akele, Nnedindu Asogwa, Gennifer Wahbah Makhoul, Khalil El-Gharib, Joanne Ling, Alaukika Agarwal, Vanessa Agberien, Ngowari Pokima, Thomas Gut, Suzanne El-Sayegh, Nidhi Chaudhary   +10 more
wiley   +1 more source

Fibroids in obstructed hemivagina and ipsilateral renal anomaly‐like syndrome: Successful hysterectomy and vaginal septoplasty in a kidney transplant recipient with uterus didelphys, vaginal septum and renal agenesis

International Journal of Gynecology &Obstetrics, Volume 174, Issue 1, Page 491-493, July 2026.
Mariana Correia Moreira Cruz, Sophia Helena Batalha, Vitor Matheus Silva, Marcos de Lorenzo Messina, José Maria Soares Junior, Edmund Chada Baracat   +5 more
wiley   +1 more source

Rapidly Progressive Multiple System Atrophy—Cerebellar Type in a 52‐Year‐Old Woman: Diagnostic Challenges in a Resource‐Limited Setting

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Multiple system atrophy (MSA) is a progressive adult‐onset neurodegenerative disorder that manifests as a variable combination of cerebellar, parkinsonian, and autonomic dysfunctions. We report a case of a 52‐year‐old woman who presented with rapidly progressive gait ataxia, dysarthria, orthostatic hypotension, and urinary urgency.
Khushi V. Singh, Sai Priya Nimmagadda, Ameesh Panda, Rarigela Rohith, Tirth J. Patel, Sonika Gopathoti, Prajesh V. Patel, Mihirkumar P. Parmar, Saleh Mohammed   +8 more
wiley   +1 more source

Pharmacogenetic associations of MMP9 and MMP12 variants with cardiovascular disease in patients with hypertension.

PLoS ONE, 2011
ObjectivesMMP-9 and -12 function in tissue remodeling and may play roles in cardiovascular disease (CVD). We assessed associations of four MMP polymorphisms and three antihypertensive drugs with cardiovascular outcomes.MethodsHypertensives (n = 42,418 ...
Rikki M Tanner, Amy I Lynch, Victoria H Brophy, John H Eckfeldt, Barry R Davis, Charles E Ford, Eric Boerwinkle, Donna K Arnett   +7 more
doaj   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1350-1365, December 2025.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Medication adherence in patients with acutely decompensated heart failure: A cross‐sectional study in the emergency department (ADHF‐ED)

European Journal of Heart Failure, Volume 27, Issue 12, Page 2763-2772, December 2025.
The ADHF‐ED trial. ADHF, acutely decompensated heart failure; CHF, chronic heart failure; ED, emergency department; EF, ejection fraction; MRA, mineralocorticoid receptor antagonist; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide. Created with the support of AI (ChatGPT).
Michael Kunz, Juel Maalouli Schaar, Katharina R. Welker, Lucas Lauder, Felix Götzinger, Ingrid Kindermann, Martin Schulz, Michael Böhm, Markus R. Meyer, Felix Mahfoud   +9 more
wiley   +1 more source

Clinical utility of azilsartan–chlorthalidone fixed combination in the management of hypertension

Vascular Health and Risk Management, 2012
Jerrica E Shuster,1,2 Barry E Bleske,1,2 Michael P Dorsch1,21University of Michigan Hospitals and Health Centers, Ann Arbor, MI, USA; 2College of Pharmacy, University of Michigan, Ann Arbor, MI, USAAbstract: Azilsartan–chlorthalidone fixed ...
Shuster JE, Bleske BE, Dorsch MP
doaj  

Circulating microRNA Biomarkers of Thiazide Response in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Thiazide diuretics are the second most frequently prescribed class of antihypertensives, but up to 50% of patients with hypertension have minimal antihypertensive response to thiazides.
Lakshmi Manasa S. Chekka, Marwa Tantawy, Taimour Langaee, Danxin Wang, Rolf Renne, Arlene B. Chapman, John G. Gums, Eric Boerwinkle, Rhonda M. Cooper‐DeHoff, Julie A. Johnson   +9 more
doaj   +1 more source