Results 41 to 50 of about 4,532 (203)

Optimized and Validated RP-UPLC Method for the Determination of Losartan Potassium and Chlorthalidone in Pharmaceutical Formulations [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: A validated ultra performance liquid chromatography (UPLC) method has been developed and validated for the simultaneous determination of losartan potassium and chlorthalidone in pharmaceutical preparations.
Tadiboyina Sirisha, Bannimath Gurupadayya, Sridhar Siddiraju   +2 more
doaj   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Efficacy of Low-Dose Chlorthalidone and Hydrochlorothiazide as Assessed by 24-h Ambulatory Blood Pressure Monitoring [PDF]

, 2016
BackgroundThiazide and thiazide-like diuretic agents are being increasingly used at lower doses. Hydrochlorothiazide (HCTZ) in the 12.5-mg dose remains the most commonly prescribed antihypertensive agent in the United States.ObjectivesThis study compared
Kumbla, Mukund M., Chandurkar, Nitin B., Sharma, Kamal H., Mathur, Shyam L., Agarwal, Manish A., Pareek, Anil K., Dharmadhikari, Shruti K., Godbole, Anil V., Messerli, Franz H., Kshirsagar, Prasita P.   +9 more
core   +1 more source

Risk of hospitalized and non-hospitalized gastrointestinal bleeding in ALLHAT trial participants receiving diuretic, ACE-inhibitor, or calcium-channel blocker.

PLoS ONE, 2021
ObjectivesThis post-trial data linkage analysis was to utilize the data of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants linked with their Medicare data to examine the risk of hospitalized and non ...
Xianglin L Du, Lara M Simpson, Brian C Tandy, Judith L Bettencourt, Barry R Davis   +4 more
doaj   +2 more sources

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Low-Dose Triple Antihypertensive Combination Therapy in Patients with Hypertension: A Randomized, Double-Blind, Phase II Study

Drug Design, Development and Therapy, 2020
Soon Jun Hong,1,* Ki-Chul Sung,2,* Sang-Wook Lim,3 Seok-Yeon Kim,4 Weon Kim,5 Jinho Shin,6 Sungha Park,7 Hae-Young Kim,8 Moo-Yong Rhee9,10 On behalf of MH_APOLLO to read: HM_APOLLO1Department of Cardiology, Cardiovascular Center, Korea University Anam ...
Hong SJ, Sung KC, Lim SW, Kim SY, Kim W, Shin J, Park S, Kim HY, Rhee MY   +8 more
doaj  

Mechanism of chronic hypocalciuria with chlorthalidone: reduced calcium absorption

, 1984
Chlorthalidone, like other benzothiadiazides, lowers urine calcium excretion chronically. If intestinal calcium absorption did not fall or bone accretion did not increase, serum calcium and the filtered load of calcium would increase and urine calcium ...
D. A. Bushinsky, F. L. Coe, M. J. Favus
core   +1 more source

Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form

Open Chemistry, 2021
Five various chemometric methods were established for the simultaneous determination of azilsartan medoxomil (AZM) and chlorthalidone in the presence of azilsartan which is the core impurity of AZM.
Darwish Hany W., Al Majed Abdulrahman A., Al-Suwaidan Ibrahim A., Darwish Ibrahim A., Bakheit Ahmed H., Al-Shehri Hassan H.   +5 more
doaj   +1 more source

Atrial High‐Rate Episodes Mirror Atrial Fibrillation in Stroke Prediction: Evidence From an Indian Prospective Cohort

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
This prospective matched cohort study, which generates hypotheses, finds that device‐detected AF lasting under 24 h is linked to a notably increased risk of stroke/TIA and progression to clinical AF among Indian patients. ABSTRACT Aims To assess the risk of stroke/TIA and progression to atrial fibrillation (AF) in Indian patients with device‐detected ...
Sedhupathi Shanmugam, Sreevilasam P. Abhilash, Jyothi Vijay, Sapna erat Sreedharan, Narayanan Namboodiri   +4 more
wiley   +1 more source

Inhibition of Ca absorptive flux by chlorthalidone in the rat duodenum and colon

, 1986
To evaluate the mode and intestinal sites of action of chlorthalidone on Ca transport, balance and flux studies by the Ussing technique were performed in rats fed a low Ca diet throughout the experiment to stimulate Ca absorption.
K. Lau, S. Kathpalia, U. Gafter, J. Garno   +3 more
core   +1 more source