Results 71 to 80 of about 3,434 (226)

Updating the list of known opioids through identification and characterization of the new opioid derivative 3,4-dichloro-N- (2-(diethylamino)cyclohexyl)-N- methylbenzamide (U-49900) [PDF]

, 2017
New psychoactive substances have been rapidly growing in popularity in the drug market as non-illegal drugs. In the last few years, an increment has been reported on the use of synthetic alternatives to heroin, the synthetic opioids.
Carbón, X., Fabregat-Safont, David, Fornís, I., Guillamón, Eva, Hernandez, Felix, Ibáñez, Maria, Sancho, Juan V, Ventura, Mireia   +7 more
core   +1 more source

Von Sauerstoff zu Tellur: Der Einfluss des Chalkogenatoms auf die Nucleophilie und Basizität von Isochalkogenharnstoff‐basierten Katalysatoren

Angewandte Chemie, Volume 137, Issue 48, November 24, 2025.
Der Einbau verschiedener Chalkogenatome (O, S, Se oder Te) in häufig verwendete Isochalkogenharnstoff‐Organokatalysatoren ermöglicht die Feinabstimmung ihrer Nucleophilie und Basizität. Kinetische und thermodynamische Deskriptoren für die molekularen Eigenschaften der Katalysatoren werden als Werkzeuge zur Vorhersage ihrer Effizienz eingeführt und in ...
Lotte Stockhammer, Kevin Kasten, Andreas Eitzinger, Lukas S. Vogl, Magdalena Piringer, David Weinzierl, Armin R. Ofial, Andrew D. Smith, Mario Waser   +8 more
wiley   +1 more source

Insertion of Nitriles Into a Gold(III)/Carbene Bond: A Direct and Powerful Entry to Imino‐Substituted Carbenes

Angewandte Chemie, Volume 137, Issue 23, June 2, 2025.
Stable imino‐substituted Au(III) carbenes are easily and efficiently prepared by trapping the transient (N^C^C)Au←:CH(dmp)+ carbene with nitriles. The corresponding free species are readily generated and display dual carbene / nitrile‐ylide reactivities. The diazo decomposition, nitrile insertion, and carbene transfer can be combined in three‐component
Rui Wei, Nina Albouy, Sonia Mallet‐Ladeira, Karinne Miqueu, Didier Bourissou   +4 more
wiley   +2 more sources

Carbene-Catalyzed [4 + 2] Annulation of 2 H-Azirine-2-carboxaldehydes with Ketones via Azolium Aza-Dienolate Intermediate.

Organic Letters, 2018
A new carbene-catalyzed [4 + 2] annulation of 2 H-azirine-2-carbaldehydes with ketones was developed, thus providing the 2,3-dihydro-6 H-1,3-oxazin-6-one core structures with broad scope and good to excellent yields.
Qiupeng Peng, Bei Zhang, Yang Xie, Jian Wang   +3 more
semanticscholar   +1 more source

From Oxygen to Tellurium: The Impact of the Chalcogen on Nucleophilicities and Basicities of Isochalcogenourea Catalysts

Angewandte Chemie International Edition, Volume 64, Issue 48, November 24, 2025.
Incorporation of different chalcogen atoms allows for the fine‐tuning of nucleophilicity and basicity of commonly used isochalcogenourea organocatalyst scaffolds. Kinetic and thermodynamic descriptors for the molecular properties of the catalysts are introduced as tools to predict their efficiency and tested in acyl transfer and allenoate activation ...
Lotte Stockhammer, Kevin Kasten, Andreas Eitzinger, Lukas S. Vogl, Magdalena Piringer, David Weinzierl, Armin R. Ofial, Andrew D. Smith, Mario Waser   +8 more
wiley   +1 more source

Chemistry of 1,3-Dioxepins. XVI.1 The Synthesis, Characterization and Crystallographic Analysis of Some Arylsulphanyl-, Arylsulphinyl-, Arylsulphonyl- and Benzoyl- N-Substituted Derivatives of 1a,2,6,6a-Tetrahydro-1H,4H-[1,3]dioxepino[5,6-b]azirines [PDF]

, 2006
Chemo-selective synthesis and characterization of N-[(4-nitrophenyl)sulphanyl]- 2 and N-[(4- nitrophenyl)sulphinyl]- 3 N-[(4-aminophenyl)sulphonyl]- 5 and N-(4-aminobenzoyl)- 7 derivatives of 1a,2,6,6a-tetrahydro-1H,4H-[1,3]dioxepino[5,6-b]azirines ...
Biserka Prugovečki, Marina Marinković, Miljenko Dumić, Mladen Vinković   +3 more
core   +1 more source

2H-Pyrrole und Pyrrole aus 3-Phenyl-2H-azirinen

CHIMIA, 1976
Vinyl-phosphonium salts [2] and phenyl-vinyl-sulfone or divinylsulfone react with benzonitril-methylides a (which are photochemically generated from 3-phenyl-2H-azirines 1 and 2) to give, via the nonisolated intermediates of type b, 2H-pyrrole 4 and the
Ulrich Widmer, Nikolas Gakis, Bruno Arnet, Heinz Heimgartner, Hans Schmid   +4 more
doaj   +1 more source

Molecular basis for functional switching of GFP by two disparate non-native post-translational modifications of a phenyl azide reaction handle [PDF]

, 2016
Through the genetic incorporation of a single phenyl azide group into superfolder GFP (sfGFP) at residue 148 we provide a molecular description of how this highly versatile chemical handle can be used to positively switch protein function in vitro and in
Hartley, Andrew M., Jones, D. Dafydd, Reddington, Samuel C., Rizkallah, Pierre J., Worthy, Harley L.   +4 more
core   +3 more sources

Non-natural 2H-azirine-2-carboxylic acids: an expedient synthesis and antimicrobial activity

RSC Advances, 2019
Non-natural 2H-azirine-2-carboxylic acids were obtained in high yields by FeCl2-catalyzed isomerization of 5-chloroisoxazoles to azirine-2-carbonyl chlorides followed by their hydrolysis.
P. Sakharov, Alexander N. Koronatov, A. Khlebnikov, M. Novikov, A. Glukharev, E. Rogacheva, L. Kraeva, V. Sharoyko, T. Tennikova, N. Rostovskii   +9 more
semanticscholar   +1 more source

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source