Results 81 to 90 of about 1,721 (198)

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

European Journal of Organic Chemistry, Volume 28, Issue 38, October 15, 2025.
Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine‐containing analogues. Fluorine atoms placed strategically into bioactive molecules often enhance essential pharmacokinetic parameters like ...
Ivette Morales‐Salazar, Perla Islas‐Jácome, Leonardo D. Herrera‐Zuñiga, Samuel Couve‐Bonnaire, Philippe Jubault, Eduardo González‐Zamora, Jean‐Philippe Bouillon, Alejandro Islas‐Jácome   +7 more
wiley   +1 more source

University of Zurich Hosts Symposium in Honor of Professor Heinz Heimgartner

CHIMIA, 2006
The Institute of Organic Chemistry of the University of Zürich hosted a symposium in honor of Prof. Heinz Heimgartner on June 9, 2006. PO Dr. Simon M. Ametamey, Dr. Kurt Dietliker, Prof. Grzegorg Mloston, Dr. Daniel Obrecht, Prof.
Annette Rahm
doaj   +1 more source

Aromaticity and Photoreactivity of 4‐ and 3‐Nitrenopyridine 1‐Oxides and Phenylnitrene

Journal of Physical Organic Chemistry, Volume 38, Issue 10, October 2025.
NICS(1.7)zz, ACID, and spin density calculations reveal that triplet 4‐nitrenopyridine oxide, 3‐nitrenopyridine oxide, and phenylnitrene display Baird triplet aromaticity. These findings help clarify the relationships between structure and aromaticity in triplet arylnitrenes. ABSTRACT The pursuit of sustainable organic synthesis has renewed interest in
Fiona J. Wasson, Anindya Borah, Dmitrii Govorov, W. Dinindu Mendis, James S. Poole, Bruce S. Ault, William L. Karney, Anna D. Gudmundsdottir   +7 more
wiley   +1 more source

Novel aziridine esters by the addition of aromatic nitrogen heterocycles to a 2H-azirine-3-carboxylic ester [PDF]

, 2000
Methyl 2-(2,6-dichlorophenyl)-2H-azirine-3-carboxoylate acts as an efficient alkylating agent for a variety of five-membered aromatic heterocycles. The aziridines derived from heterocycles that bear an alpha-carbonyl substituent react with TFA to give ...
Alves, Maria José Chão, Ferreira, Paula M. T., Gilchrist, T. L., Maia, Hernâni Lopes Silva, Monteiro, Luís S.   +4 more
core   +1 more source

Intermolecular alkyl radical addition to methyl 2-(2,6-dichlorophenyl)-2H-azirine-3-carboxylate [PDF]

, 2003
The 2H-azirine 1 acts as an effective radical acceptor for secondary and tertiary alkyl iodides mediated by triethylborane. The addition proceeds with high regio- and diastereo-selectivity.The present work has been supported by Fundação para a Ciência e ...
Alves, Maria José Chão, Fortes, A. Gil, Guimarães, Emanuel, Lemos, Américo   +3 more
core   +1 more source

I. The Synthesis, Absolute Configuration, and Stereochemistry of Thermal Decomposition of (+)-3R,5R- and (+)-3R,5S-3-Ethyl-5-Methyl-1-Pyrazoline. II. Mechanistic Investigations of the Thermal Decompositions of 2H-Azirines [PDF]

, 1976
I. (+)-3R,5R- and (+)-3R,5S-3-ethyl-5-methyl-1-pyrazolines (34T and 34C, respectively) have been prepared in optically active form. Their stereochemistries have been determined by correlation with (-)-R-3-hexanol and (-)-R-2-bromohexane.
Wendling, Larry Allan
core   +1 more source

Methyl (1aRS,7aSR)-7-formyl-1a-phenyl-1,1a-dihydroazirino[2,3-b]benzo[e][1,4]thiazine-7a(7H)-carboxylate

Molbank
The first representative of the aziridine-fused benzo[e][1,4]thiazine series was synthesized from methyl 2-bromo-2-phenyl-2H-azirine-2-carboxylate and benzo[d]thiazole in 74% yield.
Ilya P. Filippov, Anastasiya V. Agafonova, Nikolai V. Rostovskii, Mikhail S. Novikov   +3 more
doaj   +1 more source

Study based on electronic descriptors of the diastereoselective aza-diels-alder cycloaddition of [(1r)-10-(n,n-diethylsulfamoyl)isobornyl] 2h-azirine-3-carboxylate to e,e-1,4-diacetoxy-1,3-butadiene [PDF]

, 2013
Cycloaddition of chiral [(1R)-10-(N,N-diethylsulfamoyl)isobornyl] 2H-azirine-3-carboxylate to E,E-1,4-diacetoxy-1,3-butadiene shows complete diatereoselectivity giving a single cycloadduct (-)-(2S,5R,6R)-6-[(1R)-10-(N,N-diethylsulfamoyl ...
Alves, Maria José Chão, Molina, Reinaldo, Rodríguez-Borges, José E., Ruiz-Blanco, Yasser B.   +3 more
core   +1 more source

Ethyl 2-(Diisopropoxyphosphoryl)-2H-Azirine-3-Carboxylate: Reactions with Activated 1,3-Butadienes [PDF]

, 2008
The 12th International Electronic Conference on Synthetic Organic Chemistry session General Organic SynthesisEthyl 2-(diisopropoxyphosphoryl)-2H-azirine-3-carboxylate was generated “in situ” and reacted with a number of 1,3-butadienes.
Alves, M. José, García Mera, Xerardo Xusto, Lemos, Américo, Rodríguez Borges, José E.   +3 more
core   +1 more source

Aminophosphonsäuren: Synthese der α-Aminophosphonsäuren aus aliphatischen Aldazinen unter Anwendung von Diisopropylphosphit [PDF]

, 1976
A new efficient synthesis of α-aminophosphonic acids from aliphatic aldazines and diisopropyl phosphite is ...
Hoffmann, Maria, Rachoń, J., Wasielewski, C.   +2 more
core   +2 more sources