Results 121 to 130 of about 34,737 (245)

Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Jaborandi (Pilocarpus microphyllus) essential oil is obtained by removal and characterization using GC‐MS, revealing γ‐cadinene and trans‐caryophyllene as major constituents. The oil exhibits biological activity, with antifungal action against Candida spp.
Juniel Cruz Silva, Maria Gabriela Araújo Mendes, Paulo Sérgio de Araujo Sousa, Alyne Rodrigues de Araújo Nobre, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Tatiane Caroline Daboit, José de Sousa Lima Neto, Ygor Victor Ferreira Pinheiro, Ytallo da Costa Sousa, Edymilaís da Silva Sousa, José Delano Barreto Marinho Filho, Ana Jérsia Araújo, Francisco Artur Silva Filho, Sidney Gonçalo de Lima, Leiz Maria Costa Véras   +15 more
wiley   +1 more source

Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres‐Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, Diógenes Aparício Garcia Cortez, Benedito Prado Dias Filho   +8 more
wiley   +1 more source

Farmacología de los azoles [PDF]

, 2007
Azole antifungals have different pharmacokinetic characteristics: complete oral absorption for Voriconazole, and to a lesser extent for fluconazole. The absorption of posaconazole and itraconazole increases with food intake.
Azanza, J.R. (José Ramón), Garcia-Quetglas, E. (Emilio), Sadaba, B. (Belén)   +2 more
core  

Candida auris in Heart Transplant Donor: First Isolation in a Southern Italy Heart Transplant Center

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Timeline of infection control in a heart transplant from a donor colonized with Candida auris: from detection at retrieval to strict isolation, antifungal prophylaxis, negative follow‐up cultures, and successful prevention of transmission. ABSTRACT Candida auris is an emerging multidrug‐resistant fungal pathogen increasingly implicated in healthcare ...
Lorenzo Giovannico, Giuseppe Fischetti, Luca Savino, Giuseppina Caggiano, Maria Chironna, Silvio Tafuri, Tomaso Bottio   +6 more
wiley   +1 more source

[Azole-resistant invasive aspergillosis].

Nederlands tijdschrift voor geneeskunde, 2009
Contains fulltext : 79815.pdf (Publisher’s version ) (Open Access)
Linden, J.W.M. van der, Warris, A., Meer, J.W.M. van der, Bresters, D., Melchers, W.J.G., Verweij, P.E.   +5 more
openaire   +3 more sources

A Report on the Diagnosis and Treatment of Multiple Fungal Critical Brain Abscesses A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Multiple Candida glabrata (C. glabrata) brain abscesses are an exceptionally rare central‐nervous‐system infection. Clinical data on diagnosing and managing multiple Candida glabrata brain abscesses are still scarce. Here we reported a 66‐year‐old patient with multiple C. glabrata brain abscesses confirmed by cerebrospinal‐fluid puncture.
Chongyin Zhang, Dayong Deng, Xiaoning Gao, Lei Yang, Fengzi Yao   +4 more
wiley   +1 more source

Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Methadone is used in hospitalized children to treat pain and iatrogenic opiate withdrawal. Optimal pediatric dosing for both enteral and intravenous methadone is unknown. We conducted two prospective, multi‐center, open‐label studies to characterize the pharmacokinetics of methadone in the pediatric population.
Kevin M. Watt, Elizabeth J. Thompson, Lisa Lam, Kanecia Zimmerman, Christoph P. Hornik, Andrew M. Atz, Allison Fernandez, Susan R. Hupp, Varsha Bhatt‐Mehta, Daniel K. Benjamin Jr, Ravinder Anand, Michael Cohen‐Wolkowiez, Daniel Gonzalez, P. Brian Smith, Edmund V. Capparelli, the Best Pharmaceuticals for Children Act — Pediatric Trials Network Steering Committee   +15 more
wiley   +1 more source

Persistence of triazole fungicides in agricultural topsoil is driven by reduced bioaccessibility with aging

Journal of Environmental Quality, Volume 55, Issue 1, January/February 2026.
Abstract Triazole fungicides are widely detected in agricultural soils, yet their long‐term persistence remains poorly understood. We evaluated how sorption, bioaccessibility, and degradation change with aging under field conditions. Topsoil was collected over 2 years from four Danish fields with detailed spray records. Tebuconazole, propiconazole, and
Anders R. Johnsen, Christian N. Albers, Nora Badawi, Ulla E. Bollmann   +3 more
wiley   +1 more source

Levadura asociada a Infecciones Nosocomiales y su sensibilidad a los Azoles [PDF]

, 2014
Las infecciones nosocomiales son un problema relevante de salud pública al tener gran trascendencia económica y social constituyendo un gran desafío para las instituciones de salud y para el personal médico responsable de su atención.
García Flores, Lisbet Berenice, Morales Rodríguez, Macario   +1 more
core  

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, Volume 46, Issue 1, Page 238-271, January 2026.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source