Results 111 to 120 of about 34,899 (249)
In Vitro Anti-Candida Activity of Certain New 3-(1H-Imidazol-1-yl)propan-1-one Oxime Esters
Molecules, 2013 Anti-Candida activities of certain new oximes 4a–d and their respective aromatic esters 5a–l are reported. The tested compounds 4a–d and 5a–l exhibited better anti-Candida profiles than fluconazole.
Maha S. Almutairi +3 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.ABSTRACT Asymptomatic infection poses a significant risk for children undergoing hematopoietic stem cell transplantation (HSCT). Pre‐transplant surveillance computed tomography (CT) is commonly used to identify occult infection, though its diagnostic yield remains uncertain.
Tyler Obermark +9 more
wiley +1 more source
The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors
Frontiers in Microbiology, 2019 CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice.
Jingxiang Zhang +8 more
doaj +1 more source
Vaginal azoles versus oral fluconazole in treatment of recurrent vulvovaginal candidiasis [PDF]
Background: Vulvovaginal candidiasis (VVC) is a fungal infection of the vagina and vulva. It is usually caused by Candida albicans, however, occasionally other candida species are responsible. The optimal treatment of VVC has not yet been defined.
تلو, مهشید +3 more
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Computational Design of Azole Derivatives as Multifunctional Agents for Alzheimer's Disease
Applied Organometallic Chemistry, Volume 40, Issue 5, May 2026.A series of 19 azole derivatives were evaluated using bioinformatic tools and density functional theory in the context of multifunctional agents for Alzheimer's disease and were classified as potential antioxidant, distributor, and suppressor agents. ABSTRACT Alzheimer's disease (AD) is the most common form of dementia, characterized by multifactorial ...
Nicolás Puentes‐Díaz +5 more
wiley +1 more source
MedComm, Volume 7, Issue 5, May 2026.Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang +18 more
wiley +1 more source
MedComm, Volume 7, Issue 5, May 2026.Our pilot clinical study in laryngeal transplantation achieved divergent outcomes: two cases maintained functional speech/swallowing with around 2 year graft survival and have been ongoing, while two succumbed to sepsis (10mo) and hemorrhagic recurrence (11mo).
Zheng Jiang +9 more
wiley +1 more source
Clinical Case Reports, 2019 Key Clinical Message We report the initiation of CFTR modulator lumacaftor/ivacaftor combination (LUM/IVA) in two adolescents with cystic fibrosis who were treated with antifungal azoles (AZO) and tacrolimus (TCS) for liver transplantation.
Ikrame Chouchane +2 more
doaj +1 more source
Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability
PLANTS, PEOPLE, PLANET, Volume 8, Issue 3, Page 952-964, May 2026.Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant +5 more
wiley +1 more source
Estado actual de las resistencias de Candida a los fármacos antifúngidos y estudio de los mecanismos implicados [PDF]
, 2018 [ES] El género Candida se encuentra taxonómicamente ubicado dentro del reino Fungi,subreino Dikarya y orden Sacharomycetales (Bonifaz, 2012). Se trata de una levadura redonda u ovalada de 4-6 μm de tamaño denominada blastoconidio, que forma gemaciones ...
Bilbao Bilbao, Nagore
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