Results 141 to 150 of about 23,173 (263)

Azole-Associated Pseudohyperaldosteronism: A Class Effect or Azole-Specific? [PDF]

Clinical Infectious Diseases, 2019
Adam J, Dipippo, Dimitrios P, Kontoyiannis   +1 more
openaire   +2 more sources

Integrated Approach for the Discovery of Antifungal and Antibiofilm Agents From Cerrado Plants

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
A comprehensive screening of 108 Brazilian Cerrado plant extracts identified potent inhibitors of Candida albicans biofilm formation. Active samples underwent UPLC–MS/MS and molecular networking for compound annotation, followed by in silico docking. This integrated workflow accelerates the discovery of bioactive metabolites by combining experimental ...
Lorena C. Albernaz, Amanda M. Almeida, Laís S. Morais, Alice M. S. Rodrigues, Rodrigo S. Ferreira, Laila S. Espindola, Marion Girardot, Christine Imbert   +7 more
wiley   +1 more source

Antifungal Activity and Possible Mechanism of Action of the Zn (II) Complex With a Schiff Base Against Fluconazole‐Resistant Strains of Candida spp. and Cryptococcus neoformans

Chemistry &Biodiversity, Volume 23, Issue 7, July 2026.
Addressing the global challenge of antifungal resistance, this work presents a vanillin‐derived Schiff base complexed with zinc (II) (SBZ) with potent activity against fluconazole‐resistant Candida spp. and Cryptococcus neoformans. By activating an apoptotic pathway, ranging from mitochondrial depolarization and oxidative stress to fungal DNA ...
Lívia Gurgel do Amaral Valente Sá, Cecília Rocha da Silva, João Batista de Andrade Neto, Daniel Sampaio Rodrigues, Lara Elloyse Almeida Moreira Gomes, Vitória Pessoa de Farias Cabral, Wildson Max Barbosa da Silva, Solange de Oliveira Pinheiro, Jordana Lima Braga, Bruno Coêlho Cavalcanti, Manoel Odorico de Moraes, Thais Lima Ferreira, Elaine Aires de Lima, Ana Carolina Medeiros de Oliveira, Hélio Vitoriano Nobre Júnior   +14 more
wiley   +1 more source

Pulmonary Aspergillus Nodule in an Immunocompetent Host: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Aspergillus is a common fungal pathogen that typically causes severe infections in patients with compromised immunity. This report explores a rare case of a pulmonary Aspergillus nodule in an immunocompetent person without underlying conditions. A 52‐year‐old man initially presented for evaluation of his son's allergic rhinitis, during which a
Ahmad Alikhani, Pooria Sobhanian, Mahla Hosseinzade, Shadi Shayesteh Azar, Farshad Naghshvar   +4 more
wiley   +1 more source

Combination Antifungal Therapy and Formulary Optimization for Progressive Invasive Pulmonary Aspergillosis in a Pediatric Patient With Acute Myeloid Leukemia: A Case Report

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Therapeutic response in refractory invasive pulmonary aspergillosis may depend not only on antifungal class escalation, but also on formulation choice. In this complex pediatric acute myeloid leukemia (AML) case, radiologic improvement followed combination therapy and switch to brand‐name liposomal amphotericin B, underscoring the importance ...
Faryal Khamis, Amal Al Busaidi, Kawther Al Bahrani, Asia Al‐Rashdi   +3 more
wiley   +1 more source

One‐Pot Synthesis of 2‐Arylthio‐2‐Thiazolines via a Propargylamine Cyclization—Chan‐Lam C─S Arylation Strategy

ChemCatChem, Volume 18, Issue 14, 29 July 2026.
A concise, one‐pot route to 2‐arylthio‐2‐thiazolines uses propargylamine–CS2 cyclization, followed by copper‐catalyzed Chan‐Lam C─S arylation in 2‐MeTHF under O2, employing diverse propargylamines and arylboronic acids, avoiding thiazolidine‐2‐thione isolation. Stoichiometric studies provide insights into the arylation step mechanism.
Savvas G. Chalkidis, Georgios C. Vougioukalakis   +1 more
wiley   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

From Chemistry to Clinic: Amorphous Solid-State Modification Strategies for Oral Azole Antifungals. [PDF]

ACS Omega
Harakraj TJ, Witika BA, Aucamp ME, Poka MS.   +3 more
europepmc   +1 more source

Accelerating Pediatric Oncology Drug Development: Advances in Clinical Pharmacology, Trial Design, Non‐Clinical Evidence, and Regulatory Science

The Journal of Clinical Pharmacology, Volume 66, Issue 7, July 2026.
Abstract Pediatric oncology drug development remains uniquely challenging due to the rarity and biological heterogeneity of childhood cancers, ethical considerations in trial conduct, and the limited feasibility of large, randomized studies. Despite these barriers, recent years have seen a notable acceleration in the approval of oncology therapies for ...
Ya‐Feng Wen, Xiaoning Wang, Sarandeep Boyanapalli, Lee Anderson, Thao Dang, Guan Xing, Marianna Calvet, Tiffany Hart, Sreeneeranj Kasichayanula, Xiaochen Zhao   +9 more
wiley   +1 more source