Results 131 to 140 of about 34,737 (245)

Synthesis and In Vitro Anticancer Activity of Pyrrolidone Derivatives Bearing 3,4,5-Trimethoxyphenyl Moiety as a Promising Anticancer Scaffold

Applied Sciences
A series of 5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carboxylic acid derivatives–hydrazones, N-ethylhydrazones, pyrrole, pyrazole, oxadiazole, and triazole were synthesized and evaluated for their anticancer activity using human A549 pulmonary ...
Povilas Kavaliauskas, Birutė Sapijanskaitė-Banevič, Birutė Grybaitė, Eglė Mickevičiūtė, Kazimieras Anusevičius, Andrew Garcia, Ethan Naing, Rūta Petraitienė, Vidmantas Petraitis, Ramunė Grigalevičiūtė, Vytautas Mickevičius   +10 more
doaj   +1 more source

Tinea pedis: diagnosis and management

, 2004
Tinea pedis is one of the most commonly encountered foot infections. The fact that in most cases it is easily treatable yet still prevalent in the general population suggests it is often undiagnosed or remains untreated by health care professionals and ...
Bristow, I.R.
core  

A Computational Study of the NMR Chemical Shifts of Polynitropyrazoles

Magnetic Resonance in Chemistry, Volume 64, Issue 1, Page 97-113, January 2026.
The 1H, 13C, 15N, and 17O chemical shifts of 91 nitro‐1H‐pyrazoles at GIAO/B3LYP/6‐311++G(d,p) level. The calculated chemical shifts were compared with available experimental data using an empirical equation that relates absolute shieldings to chemical shifts.
Arturo Alcorta, Rosa M. Claramunt, José Elguero, Ibon Alkorta   +3 more
wiley   +1 more source

Antifungal Susceptibility of Malassezia pachydermatis Isolates from Companion Animals and Genomic Insights into Resistance Mechanisms

Antibiotics
Background/Objectives: Malassezia pachydermatis is a lipophilic yeast frequently associated with otitis externa and dermatological disorders in companion animals. This study aimed to evaluate the antifungal susceptibility of M.
Marianna Domán, Dávid Első, Krisztina Pintér, Enikő Wehmann, Enikő Fehér, Tibor Magyar   +5 more
doaj   +1 more source

Intramolecular [3+2] Cycloaddition of Fused Azolo-Azepanes from Azido Monosaccharides Derivatives [PDF]

, 2016
Síntesis de bicíclicos compuestos empleando epoxiamidas como material de partida. Obtención de tetrazolo azepanos con posible actividad biológica.Universidad de Málaga.
Calvo-Losada, Saturnino, Pino-Gonzalez, Maria Soledad, Quirante-Sanchez, Jose Joaquin, Romero-Carrasco, Antonio   +3 more
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Piperazine Derivatives: A Privileged Scaffold in Modern Synthesis and Medicinal Chemistry

ChemistryOpen, Volume 15, Issue 1, January 2026.
Piperazine‐based bioactive molecules represent a versatile class of compounds with broad therapeutic potential. Structural modification of the piperazine scaffold governs key structure–activity relationships, enabling antibacterial, antifungal, antitumor, neuroactive, and anti‐inflammatory activities.
Assel Ten, Raushan Koizhaiganova, Dilnaz Bissenbay, Bagila Tursynova, Zhanar Zhaxibayeva, Valentina Yu   +5 more
wiley   +1 more source

Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients [PDF]

, 2017
Objectives Patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, APS-I) suffer from chronic candidosis caused mainly by Candida albicans, and repeated courses of azole antifungals have led to the development of resistance ...
Bowyer, Paul, Rautemaa, Riina, Richardson, Malcolm, Sanglard, Dominique, Saxen, Harri, Siikala, Emilia   +5 more
core  

Eugenol‐Based Thiazole Derivatives Inhibit the MepA Efflux Pump in Staphylcoccus aureus

ChemistrySelect, Volume 11, Issue 3, 22 January 2026.
ABSTRACT Multidrug resistant (MDR) bacteria are considered critical priority pathogens by the World Health Organization (WHO). Considering the relevance of antibacterial drug development in this scenario, the present research study aimed to evaluate the antibacterial activity of eugenol‐based thiazole derivatives and analyze their potential to inhibit ...
Ray Silva de Almeida, Laís Regina dos Santos Folquitto, Priscilla Ramos Freitas, Ana Carolina Justino de Araujo, Saulo Relison Tintino, Jaime Ribeiro‐Filho, Cícera Datiane de Morais Oliveira‐Tintino, Gustavo Marinho Miranda, Ivaldo Francisco da Silva Junior, Diogo Teixeira Carvalho, Thiago Belarmino de Souza, Danielle Ferreira Dias, Carolina Bandeira Domiciano, Henrique Douglas Melo Coutinho   +13 more
wiley   +1 more source

Targeted Therapy of Fungal Keratitis Enabled by Iron Nutritional Deprivation Combined With Photothermal Effect

Small Structures, Volume 7, Issue 1, January 2026.
This work developed a PDC nanoplatform that orchestrated a multimodal synergistic therapy, combining active targeting, photothermal therapy, and iron nutrient deprivation. The antifungal, anti‐inflammatory efficacy and corneal repair ability of nanoplatform were demonstrated through both in vitro and in vivo evaluations.
Ruojiao Feng, Lingshuai Meng, Shuping Zhang, Jie Zhang, Chuchu Hu, Jiaxin Zhang, Junchao Xia, Xiaoshuo Yue, Quanlin Wang, Xiaoran Liu, Wenruo Xu, Yinglun Sun, Panhong Niu, Hua Gao   +13 more
wiley   +1 more source

Important of Azoles

American International Journal of Biology and Life Sciences, 2019
Azoles are one of a cyclic  derivatives  of chemical  heterocyclic chemical and organic compounds including g a five member di unsaturated ring structure composed of  bi  nitrogen atoms at position (3 and 4) and one sulfur atom at position (1).
openaire   +1 more source