Results 91 to 100 of about 18,004 (163)

New zinc(II)-based catalyst for asymmetric azomethine ylide cycloaddition reactions

, 2006
Garner, Philip/0000-0002-6503-9550A new chiral aziridino alcohol ligand for zinc(II)-catalyzed azomethine ylide cycloadditions is described. In the presence of this catalyst, N-arylidene glycine methyl esters react with a variety of dipolarophiles to ...
Bulut, Adnan, Wiley J. Youngs, Hasan Koyuncu, Koyuncu, Hasan, Panzner, Matthew, Philip Garner, Oezdemir Dogan, Youngs, Wiley J., Matthew Panzner, Doğan, Özdemir, Garner, Philip, Adnan Bulut   +11 more
core   +1 more source

Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

Frontiers in Pharmacology
This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Luis R. Domingo, Yaseen A. M. M. Elshaier   +8 more
doaj   +1 more source

Photoinduced Non­–stabilized Azomethine Ylide Formation for the Preparation of Fluorine Containing Pyrrolidines

, 2019
International audienceA mild and reproducible method for the formation of a nonstabilized azomethine ylide was developed by photoinduced reaction catalyzed with eosin Y under green light irradiation.
Cyril Lebargy (2472826), Thibault Thierry, Emmanuel Pfund (1764274), Emmanuel Pfund, Thierry Lequeux (1764280), Cyril Lebargy, Lequeux, Thierry, Thibault, Thierry, Lebargy, Cyril, Thierry Lequeux, Thibault Thierry (6615617), Pfund, Emmanuel   +11 more
core   +1 more source

New Conjugatable Platinum(II) Chlorins: Synthesis, Reactivity and Singlet Oxygen Generation

Molecules
An efficient protocol was developed for the microwave-mediated metallation of 5-(4-methoxycarbonylphenyl)-10,15,20-tris(pentafluorophenyl)porphyrin (P1) with bis(benzonitrile)platinum dichloride salt and subsequent 1,3-dipolar cycloaddition of the ...
José Almeida, Giampaolo Barone, Luís Cunha-Silva, Ana F. R. Cerqueira, Augusto C. Tomé, Maria Rangel, Ana M. G. Silva   +6 more
doaj   +1 more source

Competing Pathways in the Azomethine Ylide Route to Indoloquinones:  An Improved Procedure for the Generation of a Transient 4-Oxazoline from the Oxazolium Salt

, 2016
Azomethine ylide generation from the oxazolium salt 22 and PhSiH3/CsF affords complex products derived from the initial cycloadduct 23 via three competing pathways.
Edwin Vedejs (1264683), Sean D. Monahan (3038127)   +1 more
core   +1 more source

Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes

International Journal of Nanomedicine, 2014
J Justin Mulvey,1,2 Evan N Feinberg,1,3 Simone Alidori,1 Michael R McDevitt,4,5 Daniel A Heller,1,6 David A Scheinberg1,5,6 1Molecular Pharmacology and Chemistry Program, Sloan Kettering Institute, New York, NY, USA; 2Tri-Institutional MD-PhD Program ...
Mulvey JJ, Feinberg EN, Alidori S, McDevitt MR, Heller DA, Scheinberg DA   +5 more
doaj  

Stereospecific Route to 5,11-Methanomorphanthridine Alkaloids via Intramolecular 1,3-Dipolar Cycloaddition of Nonstabilized Azomethine Ylide:  Formal Total Synthesis of (±)-Pancracine

, 2016
The core structure of the complex pentacyclic 5,11-methanomorphanthridine alkaloids is constructed stereospecifically in one step employing an intramolecular [3 + 2]-cycloaddition of nonstabilized azomethine ylide as the key step.
Vedavati G. Puranik (562481), Ravindra Kumar (524606), Prabal Banerjee (1565926), Ganesh Pandey (1520503)   +3 more
core   +1 more source

AZOMETHINE YLIDE CYCLOADDITION/REDUCTIVE HETEROCYCLIZATION APPROACH TO OXINDOLE ALKALOIDS: ASYMMETRIC SYNTHESIS OF (-)-HORSFILINE

, 2001
The intermolecular [3 + 2] annulation of azomethine ylides with 2(2-nitrophenyl)acrylate dienophiles followed by reductive heterocyclization affords the spiro(indole-pyrrolidine) ring system.
PALMISANO, GIOVANNI, T. PILATI, SISTI, MASSIMO, G. B. GIOVENZANA, G. PALMISANO, G. CRAVOTTO, M. SISTI, GIOVENZANA, Giovanni Battista, Tullio Pilati, Giovanni Palmisano, Giovanni Battista Giovenzana, Giancarlo Cravotto, Massimo Sisti   +12 more
core   +1 more source

Topological classification of cycloadditions occurring on-surface and in the solid-state

Communications Chemistry
The study of cycloaddition mechanisms is central to the fabrication of extended sp 2 carbon nanostructures such as graphene nanoribbons and spin chains. Reaction modeling in this context has focused mostly on putative, energetically preferred, exothermic
Juan Li, Amir Mirzanejad, Wen-Han Dong, Kun Liu, Marcus Richter, Xiao-Ye Wang, Reinhard Berger, Shixuan Du, Willi Auwärter, Johannes V. Barth, Ji Ma, Klaus Müllen, Xinliang Feng, Jia-Tao Sun, Lukas Muechler, Carlos-Andres Palma   +15 more
doaj   +1 more source

Transition-Metal-Free Access to Pyridocarbazoles from 2‑Alkynylindole-3-carbaldehydes via Azomethine Ylide

, 2018
An efficient approach for the synthesis of functionalized tetrahydro-pyrido/quinolinocarbazoles from 2-alkynylindole-3-carbaldehydes and l-proline utilizing a metal-free decarboxylative cyclization, ring expansion, and ring contraction strategy via the ...
Pawan K. Mishra, Verma, A.K., Akhilesh K. Verma (1489840), Sur, Souvik, Manoj Kumar, Shalini Verma, Souvik Sur, Verma, Shalini, Akhilesh K. Verma, Kumar, Manoj, Mishra, Pawan K, Verma, Akhilesh K, Souvik Sur (1786465), Shalini Verma (545364), Manoj Kumar (205700), Mishra, Pawan K., Pawan K. Mishra (5341643)   +16 more
core   +1 more source