Results 1 to 10 of about 1,519 (173)

Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold

Molecules, 2023
Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways.
Siva S Panda, Adel S Girgis, Marian Aziz
exaly   +5 more sources

Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins

Nature Communications, 2021
Prenylated indole alkaloids contain spirooxindole rings with a 3R or 3S carbon stereocenter, which determines their bioactivities, but the biocatalytic mechanism controlling the 3R- or 3S-spirooxindole formation was unclear.
Zhiwen Liu, Boyang Zhao, Jie Yang
exaly   +2 more sources

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation [PDF]

Frontiers in Chemistry, 2021
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis.
Yasmine M. Abdel Aziz, Gehad Lotfy, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Saied M. Soliman, Marwa M. Abu-Serie, Mohamed Teleb, Sammer Yousuf, Alexander Dömling, Luis R. Domingo, Assem Barakat   +11 more
doaj   +3 more sources

Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents

Molecules, 2021
A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins 3a–f (isatin, 3a, 6-chloroisatin, 3b, 5-fluoroisatin, 3c ...
Abdullah AL-Majid, M Ali, Mohammad Shahidul Islam   +2 more
exaly   +3 more sources

Electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives as inhibitors of acetylcholinesterase

BMC Chemistry
An efficient, reliable, and cost-effective approach was applied for the electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives.
Reem M. Elsapagh, Eman O. Osman, Ahmed M. Hafez, Hala B. El-Nassan   +3 more
doaj   +3 more sources

Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold

Frontiers in Plant Science, 2023
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Tuan-Anh M. Nguyen, Dagny Grzech, Khoa Chung, Zhicheng Xia, Trinh-Don Nguyen, Thu-Thuy T. Dang   +5 more
doaj   +1 more source

Synthesis and Diversification of Chiral Spirooxindoles via Organocatalytic Cascade Reactions

Chemistry Proceedings, 2023
The synthesis of chiral spirooxindoles through different amino catalytic activation modes is described herein. Several alkenylisatins were obtained from the Knoevenagel reaction of isatin and activated methylene derivatives containing electron ...
Jessica Navarro Vega, David Cruz Cruz, Clarisa Villegas Gómez   +2 more
doaj   +1 more source

Recent Advances in Green Approaches for Synthesis of Oxindole Derivatives [PDF]

, 2023
Oxindole derivatives are nitrogen-containing, five-membered heterocyclic molecules found in both natural and synthetic substances with diverse biological functions.
D.M.T.A.Samaradiwakara, H.H.Kandambi, K.G.U.R. Kumarasinghe   +2 more
core   +2 more sources

Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies

Molecules, 2023
Leishmaniasis is a neglected tropical disease, and there is an emerging need for the development of effective drugs to treat it. To identify novel compounds with antileishmanial properties, a novel series of functionalized spiro[indoline-3,2′-pyrrolidin]-
Nawal Kishore Sahu, Ritu Sharma, Kshirsagar Prasad Suhas, Jyoti Joshi, Kunal Prakash, Richa Sharma, Ramendra Pratap, Xiwen Hu, Sukhbir Kaur, Mukesh Jain, Carmine Coluccini, Paolo Coghi, Sandeep Chaudhary   +12 more
doaj   +1 more source

Exploring Regio- and Stereoselectivity in [3+2] Cycloaddition: Molecular Electron Density Theory Approach for Novel Spirooxindole-Based Benzimidazole with Pyridine Spacer

Crystals, 2023
A new ethylene derivative was synthesized as a precursor for the [3+2] cycloaddition (32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a pyridine spacer.
Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Mar Ríos-Gutiérrez, Assem Barakat   +4 more
doaj   +1 more source