Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
Molecules, 2023 Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways.
Siva S Panda +2 more
exaly +5 more sources
Electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives as inhibitors of acetylcholinesterase [PDF]
BMC ChemistryAn efficient, reliable, and cost-effective approach was applied for the electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives.
Reem M. Elsapagh +3 more
doaj +4 more sources
Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma [PDF]
PharmaceuticsObjectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as a potential targeted therapy for various cancers.
Assem Barakat +6 more
doaj +4 more sources
Synthesis and structural elucidation of a novel bis-spirooxindole from isatin and ethylenediamine [PDF]
Beilstein Journal of Organic ChemistryThe reactivity of isatin toward ethylenediamine displays an unexpected stoichiometric divergence, affording either the anticipated diiminoisatin or a previously unreported pentacyclic bis-spirooxindole.
Irene Moreno-Gutiérrez +7 more
doaj +2 more sources
Molecules, 2021 A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins 3a–f (isatin, 3a, 6-chloroisatin, 3b, 5-fluoroisatin, 3c ...
Abdullah Mohammed Al-Majid +2 more
exaly +3 more sources
Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines [PDF]
Frontiers in ChemistryA novel analogue of hybrid spirooxindoles was synthesized employing a systematic multistep synthetic approach. The synthetic protocol was designed to obtain a series of spirooxindole derivatives incorporating triazolyl-s-triazine framework via [3 + 2 ...
Ihab Shawish +11 more
doaj +2 more sources
The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation [PDF]
PharmaceuticalsThe p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the ...
Adel S. Girgis +8 more
doaj +2 more sources
Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules [PDF]
Frontiers in PharmacologyThis study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention.
Assem Barakat +8 more
doaj +2 more sources
Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold
Frontiers in Plant Science, 2023 Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Tuan-Anh M. Nguyen +5 more
doaj +1 more source
Nature Communications, 2021 Prenylated indole alkaloids contain spirooxindole rings with a 3R or 3S carbon stereocenter, which determines their bioactivities, but the biocatalytic mechanism controlling the 3R- or 3S-spirooxindole formation was unclear.
Zhiwen Liu +12 more
doaj +1 more source