Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
Molecules, 2023 Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways.
Mohamed Bekheit +2 more
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Synthesis and structural elucidation of a novel bis-spirooxindole from isatin and ethylenediamine [PDF]
Beilstein Journal of Organic ChemistryThe reactivity of isatin toward ethylenediamine displays an unexpected stoichiometric divergence, affording either the anticipated diiminoisatin or a previously unreported pentacyclic bis-spirooxindole.
Irene Moreno-Gutiérrez +7 more
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Molecules, 2021 A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins 3a–f (isatin, 3a, 6-chloroisatin, 3b, 5-fluoroisatin, 3c ...
M Iqbal Choudhary +2 more
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Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold
Frontiers in Plant Science, 2023 Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Khoa Chung +2 more
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Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines [PDF]
Frontiers in ChemistryA novel analogue of hybrid spirooxindoles was synthesized employing a systematic multistep synthetic approach. The synthetic protocol was designed to obtain a series of spirooxindole derivatives incorporating triazolyl-s-triazine framework via [3 + 2 ...
Ihab Shawish +11 more
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The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation [PDF]
PharmaceuticalsThe p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the ...
Adel S. Girgis +8 more
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Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma [PDF]
PharmaceuticsObjectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as a potential targeted therapy for various cancers.
Assem Barakat +6 more
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Nature Communications, 2021 Prenylated indole alkaloids contain spirooxindole rings with a 3R or 3S carbon stereocenter, which determines their bioactivities, but the biocatalytic mechanism controlling the 3R- or 3S-spirooxindole formation was unclear.
Zhiwen Liu +12 more
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Synthesis and Diversification of Chiral Spirooxindoles via Organocatalytic Cascade Reactions
Chemistry Proceedings, 2023 The synthesis of chiral spirooxindoles through different amino catalytic activation modes is described herein. Several alkenylisatins were obtained from the Knoevenagel reaction of isatin and activated methylene derivatives containing electron ...
Jessica Navarro Vega +2 more
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Molecules, 2023 Leishmaniasis is a neglected tropical disease, and there is an emerging need for the development of effective drugs to treat it. To identify novel compounds with antileishmanial properties, a novel series of functionalized spiro[indoline-3,2′-pyrrolidin]-
Nawal Kishore Sahu +12 more
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