Results 31 to 40 of about 1,381 (201)
Molecules, 2017 This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin ...
Huwaida M. E. Hassaneen +4 more
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Beilstein Journal of Organic Chemistry, 2022 In the presence of copper sulfate, three- or four-component reactions of 2-methylindole, aromatic aldehydes and various cyclic dienophiles in refluxing toluene afforded diverse spirotetrahydrocarbazoles.
Shao-Cong Zhan +3 more
doaj +1 more source
Molecules, 2021 Straightforward regio- and diastereoselective synthesis of bi-spirooxindole-engrafted rhodanine analogs 5a–d were achieved by one-pot multicomponent [3 + 2] cycloaddition (32CA) reaction of stabilized azomethine ylide (AYs 3a–d) generated in situ by ...
Assem Barakat +6 more
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, 2019 Spirooxindole derivatives are found in bioactive natural products and are used in drug discovery and related research. Here, acid-catalyzed diastereoselective intramolecular oxa-Michael cyclization reactions of β-hydroxyenones generated from enones and ...
Pasha, Maira +2 more
core +2 more sources
, 2022 Highly enantioselective synthesis of 3,3′-spirooxindole γ-lactams with three contiguous stereocenters (two quaternary) was achieved. The aza-Michael/Mannich cascade reaction of α-imine-β-oxobutanamides and methyleneindolinones catalyzed by a bifunctional
Xiao-Tong Li (560386) +2 more
core +2 more sources
Non-Covalent Organocatalyzed Domino Reactions Involving Oxindoles: Recent Advances
Molecules, 2017 The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities ...
Tecla Gasperi +3 more
doaj +1 more source
Chemical Modification of Peptides and Proteins Using Spirooxindole Oxirane Derivatives [PDF]
Methods for chemical modification of proteins and peptides at certain positions are required for the preparation of antibody-drug conjugates, protein- or peptide-biotin conjugates, and conjugates used as therapeutics or as tools in biomedical research ...
Chavan Santosh S. +2 more
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Beilstein Journal of Organic Chemistry, 2023 A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds.
Ziying Xiao +3 more
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Acta Crystallographica Section E: Crystallographic Communications, 2021 The molecular conformation of the title compound, C17H14ClN3O4, is stabilized by an intramolecular C—H...O contact, forming an S(6) ring motif. In the crystal, the molecules are connected by N—H...O hydrogen-bond pairs along the b-axis direction as ...
Farid N. Naghiyev +6 more
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Sonochemical multi-component synthesis of spirooxindoles
Ultrasonics Sonochemistry, 2011 New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Minoo, Dabiri +3 more
openaire +2 more sources