Results 31 to 40 of about 186 (130)

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, EarlyView.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source

Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H3PO4 in Aqueous Media

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan, Zhijie Zhou, Minhua Shao, Jianwei Sun   +3 more
wiley   +2 more sources

Synthesis and structural elucidation of a novel bis-spirooxindole from isatin and ethylenediamine

Beilstein Journal of Organic Chemistry
The reactivity of isatin toward ethylenediamine displays an unexpected stoichiometric divergence, affording either the anticipated diiminoisatin or a previously unreported pentacyclic bis-spirooxindole.
Irene Moreno-Gutiérrez, Josefa L. López-Martínez, Sonia Berenguel-Gómez, Irene Torres-García, Duane Choquesillo-Lazarte, Manuel Muñoz-Dorado, Miriam Álvarez-Corral, Ignacio Rodríguez-García   +7 more
doaj   +1 more source

Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine] Derivatives<em></em>

Molecules, 2012
A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and ...
Daqing Shi, Yi Zou, Wei Lin, Yucheng Wang, Changliang Xu, Xiaoguang Bai, Juxian Wang   +6 more
doaj   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Synthesis, Anticancer Activity, and Molecular Modeling of New Halogenated Spiro[pyrrolidine-thiazolo-oxindoles] Derivatives

Applied Sciences, 2020
A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70−93%) with excellent relative diastereo-, and ...
Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Fardous F. El-Senduny, Farid A. Badria, A. F. M. Motiur Rahman, Assem Barakat, Yaseen A. M. M. Elshaier   +6 more
doaj   +1 more source

Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity

Molecules, 2023
A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen ...
Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary   +12 more
doaj   +1 more source

Innovating Electrosynthesis From Metal Electrodeposition to Organic Chemistry: Deep Eutectic Solvents as Efficient and Sustainable Media

ChemSusChem, Volume 19, Issue 11, 15 June 2026.
This review analyzes deep eutectic solvents (DESs) as efficient media for both organic and inorganic electrosynthesis. The improvements in terms of synthetic opportunities and sustainability are discussed, by exploring the multiple roles of DESs as solvents, electrolytes, and promoters, enabling effective and selective electrosynthesis under mild and ...
Cristiana Margarita, Stefano Nejrotti, Alejandro Leal‐Duaso, Marta Feroci, Alessandra Sanson, Claudia Barolo, Matteo Bonomo   +6 more
wiley   +1 more source

Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells. [PDF]

PLoS ONE, 2012
Melanoma is generally refractory to current chemotherapy, thus new treatment strategies are needed. In this study, we synthesized a series of spirooxindole derivatives (SOID-1 to SOID-12) and evaluated their antitumor effects on melanoma.
Yan Tian, Sangkil Nam, Lucy Liu, Fumiko Yakushijin, Kenichi Yakushijin, Ralf Buettner, Wei Liang, Fan Yang, Yuelong Ma, David Horne, Richard Jove   +10 more
doaj   +1 more source

Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Frontiers in Oncology, 2022
Simultaneous inhibition of more than one target is considered to be a novel strategy in cancer therapy. Owing to the importance of histone deacetylases (HDACs) and p53-murine double minute 2 (MDM2) interaction in tumor development and their synergistic ...
Qian Zhao, Shan-Shan Xiong, Can Chen, Can Chen, Hong-Ping Zhu, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han   +9 more
doaj   +1 more source