Results 41 to 50 of about 1,519 (173)

The Synthesis of 3-Spirooxindole Derivatives. IV. The Conversion of 3-Spirooxindole to Indole Derivative.

Chemical and Pharmaceutical Bulletin, 1963
The conversion of 1-methylspiro (indoline-3, 1'-indolizine)-2-one to 12-methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine is described as a preliminary for the chemical correlation of N-methylrhynchophyllane with N-methyldihydrocorynantheane.
T, OISHI, S, MAENO, Y, BAN
openaire   +3 more sources

Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H3PO4 in Aqueous Media

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan, Zhijie Zhou, Minhua Shao, Jianwei Sun   +3 more
wiley   +2 more sources

Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

Frontiers in Pharmacology, 2022
A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under
Huajie Li, Huajie Li, Zhenjie Yu, Zhenjie Yu, Haoyi Sun, Haoyi Sun, Bo Liu, Bo Liu, Xin Wang, Xin Wang, Zhe Shao, Zhe Shao, Meiling Wang, Meiling Wang, Weilin Xie, Weilin Xie, Xingang Yao, Qingqiang Yao, Qingqiang Yao, Ying Zhi, Ying Zhi   +20 more
doaj   +1 more source

An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H) [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2016
One-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of spirooxindole dipyrimidines.
Ghodsi Mohammadi Ziarani, Faezeh Aleali, Negar Lashgari, Alireza Badiei   +3 more
doaj  

Therapeutic Potential of Spirooxindoles as Antiviral Agents [PDF]

ACS Infectious Diseases, 2016
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug ...
Na, Ye, Haiying, Chen, Eric A, Wold, Pei-Yong, Shi, Jia, Zhou   +4 more
openaire   +2 more sources

Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine] Derivatives<em></em>

Molecules, 2012
A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and ...
Daqing Shi, Yi Zou, Wei Lin, Yucheng Wang, Changliang Xu, Xiaoguang Bai, Juxian Wang   +6 more
doaj   +1 more source

Synthesis, Anticancer Activity, and Molecular Modeling of New Halogenated Spiro[pyrrolidine-thiazolo-oxindoles] Derivatives

Applied Sciences, 2020
A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70−93%) with excellent relative diastereo-, and ...
Mohammad Shahidul Islam, Abdullah Mohammed Al-Majid, Fardous F. El-Senduny, Farid A. Badria, A. F. M. Motiur Rahman, Assem Barakat, Yaseen A. M. M. Elshaier   +6 more
doaj   +1 more source

Chemo-/Regio-Selective Synthesis of Novel Functionalized Spiro[pyrrolidine-2,3′-oxindoles] under Microwave Irradiation and Their Anticancer Activity

Molecules, 2023
A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen ...
Richa Sharma, Lalit Yadav, Ali Adnan Nasim, Ravi Kant Yadav, Rui Hong Chen, Neha Kumari, Fan Ruiqi, Ashoke Sharon, Nawal Kishore Sahu, Sirish Kumar Ippagunta, Paolo Coghi, Vincent Kam Wai Wong, Sandeep Chaudhary   +12 more
doaj   +1 more source

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines [PDF]

, 2018
We developed two Ugi-type three-component reactions of spirooxindole-fused 3-thiazolines, isocyanides, and either carboxylic acids or trimethylsilyl azide, to give highly functionalized spirooxindole-fused thiazolidines.
Begnini, Fabio, De Munnik, Mariska, Lesma, Giordano, Lo Presti, Leonardo, Orru, Romano, Rainoldi, Giulia, Ruijter, Eelco, Silvani, Alessandra, Vande Velde, Christophe M.L.   +8 more
core   +3 more sources

A Simple and Efficient Two-step Synthesis of Hexahydro-diazecane-dione Derivatives [PDF]

, 2022
Various substituted Dispiro [pyrrolo-piperazino-oxindole] have been synthesized by utilizing a simple and efficient two-step synthetic protocol by Grubbs metathesis in dichloromethane at 40°C.
Shyamal Mondal
core   +2 more sources