Results 41 to 50 of about 1,562 (203)

Crystal structure and Hirshfeld surface analysis of ethyl 6′-amino-2′-(chloromethyl)-5′-cyano-2-oxo-1,2-dihydrospiro[indoline-3,4′-pyran]-3′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2021
The molecular conformation of the title compound, C17H14ClN3O4, is stabilized by an intramolecular C—H...O contact, forming an S(6) ring motif. In the crystal, the molecules are connected by N—H...O hydrogen-bond pairs along the b-axis direction as ...
Farid N. Naghiyev, Maria M. Grishina, Victor N. Khrustalev, Mehmet Akkurt, Afet T. Huseynova, Anzurat A. Akobirshoeva, İbrahim G. Mamedov   +6 more
doaj   +1 more source

An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H) [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2016
One-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of spirooxindole dipyrimidines.
Ghodsi Mohammadi Ziarani, Faezeh Aleali, Negar Lashgari, Alireza Badiei   +3 more
doaj  

Sonochemical multi-component synthesis of spirooxindoles

Ultrasonics Sonochemistry, 2011
New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Minoo, Dabiri, Zeinab Noroozi, Tisseh, Mahboobeh, Bahramnejad, Ayoob, Bazgir   +3 more
openaire   +2 more sources

Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

Frontiers in Pharmacology, 2022
A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under
Huajie Li, Huajie Li, Zhenjie Yu, Zhenjie Yu, Haoyi Sun, Haoyi Sun, Bo Liu, Bo Liu, Xin Wang, Xin Wang, Zhe Shao, Zhe Shao, Meiling Wang, Meiling Wang, Weilin Xie, Weilin Xie, Xingang Yao, Qingqiang Yao, Qingqiang Yao, Ying Zhi, Ying Zhi   +20 more
doaj   +1 more source

Multicomponent reactions for DNA‐encoded library construction: Scaffold diversity and reaction engineering strategies

Bulletin of the Korean Chemical Society, EarlyView.
Abstract DNA‐encoded libraries (DELs) enable large‐scale screening for hit identification, but accessing sp3‐rich, three‐dimensional chemotypes beyond flat, aromatic scaffolds remains challenging. Multicomponent reactions (MCRs) assemble such complexity from simple building blocks in a single step, and reaction‐engineering strategies have extended on ...
Jimin Moon, Hyemin Yoon, Kang Ju Lee, Hyun Jin Kim   +3 more
wiley   +1 more source

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation

Frontiers in Chemistry, 2021
The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis.
Yasmine M. Abdel Aziz, Gehad Lotfy, Mohamed M. Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Saied M. Soliman, Marwa M. Abu-Serie, Mohamed Teleb, Sammer Yousuf, Alexander Dömling, Luis R. Domingo, Assem Barakat   +11 more
doaj   +1 more source

Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Enantioselective Synthesis of Spirooxindole-Fused Thiaindans

, 2018
An asymmetric strategy for the construction of chiral sulfur-containing spirooxindole-fused heterocycles was achieved via a rhodium­(II)/chiral phosphoric acid-cocatalyzed reaction between 2-mercaptophenyl ketones and 3-diazooxindoles.
Dong Xing (760733), Chaoqun Ma (1867639), Wenhao Hu (523363), Tiantian Chen (1655986), Guolan Xiao (3356087)   +4 more
core   +1 more source

Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine] Derivatives<em></em>

Molecules, 2012
A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and ...
Daqing Shi, Yi Zou, Wei Lin, Yucheng Wang, Changliang Xu, Xiaoguang Bai, Juxian Wang   +6 more
doaj   +1 more source

Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE

Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.
This study reveals that MarE, a heme‐dependent aromatic oxygenase, favors dioxygenation of β‐methyl‐l‐tryptophan in the absence of ascorbate and demonstrates how structural and redox tuning shifts its reactivity toward selective monooxygenation, yielding a 2‐oxindole scaffold. These findings offer new insights into enzyme‐controlled indole oxidation in
Romie C. Nguyen, Inchul Shin, Aimin Liu
wiley   +2 more sources

Ion‐Channel Activity of Characteristic Alkaloids From Uncaria rhynchophylla

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Eleven characteristic alkaloids with rhynchophylline‐type and corynanthe‐type scaffolds were isolated from Uncaria rhynchophylla and evaluated against Nav1.7, Nav1.5, Cav3.1, and Kv1.5. Corynanthe‐type alkaloids showed stronger inhibition of Nav1.7, Nav1.5, and Cav3.1, whereas Kv1.5 was less sensitive and displayed a distinct response pattern ...
Wen‐Yan Li, Qi Wu, Zhi‐Ping Zhou, Zai‐Feng Yuan, Qin‐Shi Zhao   +4 more
wiley   +1 more source