Results 51 to 60 of about 1,562 (203)
Applied Sciences, 2020 A one-pot, single-step, and an atom-economical process towards the synthesis of highly functionalized spirooxindoles analogues was efficiently conducted to produce a satisfactory chemical yields (70−93%) with excellent relative diastereo-, and ...
Mohammad Shahidul Islam +6 more
doaj +1 more source
Molecules, 2023 A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen ...
Richa Sharma +12 more
doaj +1 more source
Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis
European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley +1 more source
Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan +3 more
wiley +2 more sources
Frontiers in Oncology, 2022 Simultaneous inhibition of more than one target is considered to be a novel strategy in cancer therapy. Owing to the importance of histone deacetylases (HDACs) and p53-murine double minute 2 (MDM2) interaction in tumor development and their synergistic ...
Qian Zhao +9 more
doaj +1 more source
Flipping the Card With Enantiodivergent Organocatalysis
Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre +3 more
wiley +1 more source
Chemical Modification of Peptides and Proteins Using Spirooxindole Oxirane Derivatives [PDF]
Methods for chemical modification of proteins and peptides at certain positions are required for the preparation of antibody-drug conjugates, protein- or peptide-biotin conjugates, and conjugates used as therapeutics or as tools in biomedical research ...
Chavan Santosh S. +2 more
core +3 more sources
Beilstein Journal of Organic Chemistry, 2014 1,3-Dipolar cycloadditions of isatins, benzylamine and benzylideneacetones were studied to prepare a series of novel spiropyrrolidine-oxindoles – 4′-acetyl-3′,5′-diarylspiro[indoline-3,2′-pyrrolidin]-2-ones and 3′-acetyl-4′,5′-diarylspiro[indoline-3,2 ...
Chuqin Peng +5 more
doaj +1 more source
ChemSusChem, Volume 19, Issue 11, 15 June 2026.This review analyzes deep eutectic solvents (DESs) as efficient media for both organic and inorganic electrosynthesis. The improvements in terms of synthetic opportunities and sustainability are discussed, by exploring the multiple roles of DESs as solvents, electrolytes, and promoters, enabling effective and selective electrosynthesis under mild and ...
Cristiana Margarita +6 more
wiley +1 more source
A synergetic effect of sonication with yolk-shell nanocatalyst for green synthesis of spirooxindoles
Green Chemistry Letters and Reviews, 2021 A synergetic effect of ultrasonic irradiation and yolk–shell nanocatalyst was examined for the synthesis of spirooxindoles from isatin, malononitrile and cyclohexanone.
Somaye Mohammadi, Hossein Naeimi
doaj +1 more source