Results 51 to 60 of about 186 (130)

Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction

Beilstein Journal of Organic Chemistry, 2013
A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst ...
Qin Fu, Chao-Guo Yan
doaj   +1 more source

Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization

Beilstein Journal of Organic Chemistry, 2012
A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai, Bo Liang, Corey R. J. Stephenson   +2 more
doaj   +1 more source

DMAP-Promoted Cascade Synthesis of Bispirooxindole–Cyclopentene–Isoxazolones

Molecules
A DMAP-catalyzed Michael addition/cyclization cascade reaction has been developed for the efficient construction of a bispirooxindole–cyclopentene–isoxazolone framework. Under the optimized conditions (10 mol% DMAP, CH2Cl2, room temperature), the desired
Wei Zhang, Rong-Rong Zhu, Da-Ming Du
doaj   +1 more source

New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4′- (1′,4′-dihydropyridine)] Derivatives

Molecules, 2015
Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-[indole-3,4′-(1′,4′-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the ...
Fernando Auria-Luna, Eugenia Marqués-López, Somayeh Mohammadi, Roghayeh Heiran, Raquel P. Herrera   +4 more
doaj   +1 more source

Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions

ChemSusChem, Volume 18, Issue 14, July 17, 2025.
This study presents sodium bicarbonate (NaHCO3) as a safe, solid source of CO2 for mechanochemical carboxylation reactions. Mechanochemical methods for synthesizing cyclic carbamates and organic carbonates from NaHCO3 are developed. This approach holds significant potential for pharmaceutical applications, highlighting solvent‐minimized synthesis and ...
Francesco Mele, Andrea Aquilini, Ana Maria Constantin, Francesco Pancrazzi, Lara Righi, Andrea Porcheddu, Raimondo Maggi, Daniele Alessandro Cauzzi, Giovanni Maestri, Elena Motti, Luca Capaldo, Nicola Della Ca'   +11 more
wiley   +1 more source

Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

Frontiers in Chemistry
Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery ...
Mohamed S. Nafie, Mohamed S. Nafie, Abdullah Mohammed Al-Majid, M. Ali, Abdulmajeed Abdullah Alayyaf, Matti Haukka, Sajda Ashraf, Zaheer Ul-Haq, Ayman El-Faham, Assem Barakat   +9 more
doaj   +1 more source

A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

Frontiers in Chemistry, 2019
Brain tumor, as any type of cancer, is assumed to be sustained by a small subpopulation of stem-like cells with distinctive properties that allow them to survive conventional therapies and drive tumor recurrence. Thus, the identification of new molecules
Joana D. Amaral, Dário Silva, Cecília M. P. Rodrigues, Susana Solá, Maria M. M. Santos   +4 more
doaj   +1 more source

Discovery, bioactivities and biosynthesis of spirooxindole alkaloids

Natural Product Reports
This review provides a comprehensive summary of the origin, activities, and biosynthesis of spirooxindole-containing alkaloids derived from a variety of organisms, including actinomycetes, cyanobacteria, fungi, plants, and invertebrates.
Ruijie Chen, Lihan Zhang, Xiaoyang Zhao, Zhuangjie Fang, Liping Zhang, Qingbo Zhang, Changsheng Zhang, Yiguang Zhu   +7 more
openaire   +2 more sources

In Vitro and In Silico Evaluation of Isatin‐Derived Spirooxindoles as Antituberculosis Drug Candidates

Chemical Biology &Drug Design, Volume 106, Issue 1, July 2025.
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
Fernanda Rodrigues de Lima, Jéssika de Oliveira Viana, Aleff Cruz de Castro, Rodrigo Cristiano, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso, Claudio Gabriel Lima‐Junior, Valnês da Silva Rodrigues‐Junior, Karen Cacilda Weber   +11 more
wiley   +1 more source

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors

Molecules, 2020
A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Mezna Saleh Altowyan, Mohammad Shahidul Islam, Abdullah Saleh Alamary, Sajda Ashraf, Zaheer Ul-Haq   +8 more
doaj   +1 more source