Results 71 to 80 of about 1,381 (201)

Catalysis With Deep Eutectic Solvents: Challenges and Opportunities

ChemCatChem, Volume 17, Issue 11, June 6, 2025.
Deep eutectic solvents (DESs) are emerging as sustainable alternatives in catalysis, offering tunable properties for diverse chemical transformations. This review explores the dual role of DESs as solvents and catalysts, highlighting advancements in organic chemistry, materials science, CO2 fixation, biomass valorization, polymer degradation, and ...
Eduardo Guzmán
wiley   +1 more source

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors

Molecules, 2020
A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Mezna Saleh Altowyan, Mohammad Shahidul Islam, Abdullah Saleh Alamary, Sajda Ashraf, Zaheer Ul-Haq   +8 more
doaj   +1 more source

Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Enantioselective Synthesis of Spirooxindole-Fused Thiaindans

, 2018
An asymmetric strategy for the construction of chiral sulfur-containing spirooxindole-fused heterocycles was achieved via a rhodium­(II)/chiral phosphoric acid-cocatalyzed reaction between 2-mercaptophenyl ketones and 3-diazooxindoles.
Dong Xing (760733), Chaoqun Ma (1867639), Wenhao Hu (523363), Tiantian Chen (1655986), Guolan Xiao (3356087)   +4 more
core   +1 more source

5′-Benzylidene-1′′-methyl-4′′-phenyltrispiro[1,3-dioxolane-2,1′-cyclohexane-3′,3′′-pyrrolidine-2′′,3′′′-indole]-4′,2′′′-dione

IUCrData, 2017
In the title compound, C32H30N2O4, two spiro links connect the methyl-substituted pyrrolidine ring to the oxindole and cyclohexanone rings. The cyclohexanone ring is further connected to the dioxalane ring by a third spiro junction.
Kuppan Chandralekha, Deivasigamani Gavaskar, Adukamparai Rajukrishnan Sureshbabu, Srinivasakannan Lakshmi   +3 more
doaj   +1 more source

Computational Design, Synthesis, and Biological Assessment of Some Pyrrolo[3,4‐c]Pyrroles Targeting Mycobacterium Tuberculosis

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya, Rajamanikandan Sundararaj, Kailasam Saravana Mani, Krishnakumar Balu, Mani Durai, Perwez Alam, Priya SD, Mathivanan Durai, Young Ho Ahn   +8 more
wiley   +1 more source

Stereoselective Synthesis of Spirooxindole Amides and Cyanohydrin Alkyl Ethers [PDF]

, 2014
A new family of spirooxindole amides were synthesized by a sequence of hydrozirconation, acylation, and intramolecular cyclization reactions. Three of the four possible diastereomers can be obtained as the major isomers through this process.
Lu, Chunliang
core  

Recent Advancements in the Cyclization Strategies of 1,3‐Enynes Towards the Synthesis of Heterocyclic/Carbocyclic Frameworks

Chemistry – An Asian Journal, Volume 20, Issue 8, April 17, 2025.
In this review, the advancements in the cyclization of 1,3‐enynes to construct structurally diverse heterocyclic and carbocyclic frameworks are portrayed comprehensively. Divergent cyclization protocols along with mechanistic aspects for key transformations are also detailed. Abstract 1,3‐Enynes have demonstrated their utility as valuable precursors to
Akash P. Sakla, Shams Aaghaz, Shujauddin Ahmed, Naziya Neshat, Ahmed Kamal   +4 more
wiley   +1 more source

Novel Spirooxindole-Benzofuran Scaffold: Potential Inhibition Against Hepatocellular Carcinoma by Targeting MDM2-p53 Interaction

We synthesized a novel compound library featuring a spirooxindole core structure combined with various heterocycles, including benzofuran, benzothiophene, and thiophene scaffolds.
Alayyaf, Abdulmajeed Abdullah, Domling, Alexander, Al-Muhanna, Muhanna K., Ul-Haq, Zaheer, Badria, Farid A., El-Senduny, Fardous F., Barakat, Assem, Islam, Mohammad Shahidul, Ali, M., Zia, Komal   +9 more
core   +1 more source

Cooperative Vinylogous Enamine and Metal Catalysis

ChemCatChem, Volume 17, Issue 7, April 4, 2025.
This review describes transformations combining vinylogous enamine catalysis with transition metal or Lewis acid catalysis that have emerged since the seminal report of dienamine catalysis in 2006. These transformations span numerous reaction classes, including alkylation, allylation, propargylation, oxyamination, dimerization, as well as cascade ...
Stacey E. Brenner‐Moyer
wiley   +1 more source

Highly Stereoselective Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans

, 2016
A Brønsted acid-catalyzed Prins-type cyclization sequence to construct spirooxindole pyrans in high yields and excellent diastereoselectivity has been developed.
Jingqi Wang (748537), Erika A. Crane (2191495), Karl A. Scheidt (493484)   +2 more
core   +2 more sources