Results 71 to 80 of about 1,562 (203)

Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization

Beilstein Journal of Organic Chemistry, 2012
A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai, Bo Liang, Corey R. J. Stephenson   +2 more
doaj   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source

Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

Frontiers in Chemistry
Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery ...
Mohamed S. Nafie, Mohamed S. Nafie, Abdullah Mohammed Al-Majid, M. Ali, Abdulmajeed Abdullah Alayyaf, Matti Haukka, Sajda Ashraf, Zaheer Ul-Haq, Ayman El-Faham, Assem Barakat   +9 more
doaj   +1 more source

New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4′- (1′,4′-dihydropyridine)] Derivatives

Molecules, 2015
Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-[indole-3,4′-(1′,4′-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the ...
Fernando Auria-Luna, Eugenia Marqués-López, Somayeh Mohammadi, Roghayeh Heiran, Raquel P. Herrera   +4 more
doaj   +1 more source

A general and efficient method to access tetracyclic spirooxindole derivatives.

, 2015
International audienceAn efficient, simple, and convenient synthetic procedure for the synthesis of tetracyclic spirooxindole derivatives, starting from N-protected isatins and 2-fluoropyridine, was successfully developed. It enables the facile formation
Troin, Yves, Abrunhosa-Thomas, Isabelle, Massip, Stéphane, Guillaumet, Gérald, Jarry, Christian, Bouakher, Abderrahman El   +5 more
core   +1 more source

A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

Frontiers in Chemistry, 2019
Brain tumor, as any type of cancer, is assumed to be sustained by a small subpopulation of stem-like cells with distinctive properties that allow them to survive conventional therapies and drive tumor recurrence. Thus, the identification of new molecules
Joana D. Amaral, Dário Silva, Cecília M. P. Rodrigues, Susana Solá, Maria M. M. Santos   +4 more
doaj   +1 more source

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors

Molecules, 2020
A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Mezna Saleh Altowyan, Mohammad Shahidul Islam, Abdullah Saleh Alamary, Sajda Ashraf, Zaheer Ul-Haq   +8 more
doaj   +1 more source

Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions

ChemSusChem, Volume 18, Issue 14, July 17, 2025.
This study presents sodium bicarbonate (NaHCO3) as a safe, solid source of CO2 for mechanochemical carboxylation reactions. Mechanochemical methods for synthesizing cyclic carbamates and organic carbonates from NaHCO3 are developed. This approach holds significant potential for pharmaceutical applications, highlighting solvent‐minimized synthesis and ...
Francesco Mele, Andrea Aquilini, Ana Maria Constantin, Francesco Pancrazzi, Lara Righi, Andrea Porcheddu, Raimondo Maggi, Daniele Alessandro Cauzzi, Giovanni Maestri, Elena Motti, Luca Capaldo, Nicola Della Ca'   +11 more
wiley   +1 more source

5′-Benzylidene-1′′-methyl-4′′-phenyltrispiro[1,3-dioxolane-2,1′-cyclohexane-3′,3′′-pyrrolidine-2′′,3′′′-indole]-4′,2′′′-dione

IUCrData, 2017
In the title compound, C32H30N2O4, two spiro links connect the methyl-substituted pyrrolidine ring to the oxindole and cyclohexanone rings. The cyclohexanone ring is further connected to the dioxalane ring by a third spiro junction.
Kuppan Chandralekha, Deivasigamani Gavaskar, Adukamparai Rajukrishnan Sureshbabu, Srinivasakannan Lakshmi   +3 more
doaj   +1 more source

Discovery, bioactivities and biosynthesis of spirooxindole alkaloids

Natural Product Reports
This review provides a comprehensive summary of the origin, activities, and biosynthesis of spirooxindole-containing alkaloids derived from a variety of organisms, including actinomycetes, cyanobacteria, fungi, plants, and invertebrates.
Ruijie Chen, Lihan Zhang, Xiaoyang Zhao, Zhuangjie Fang, Liping Zhang, Qingbo Zhang, Changsheng Zhang, Yiguang Zhu   +7 more
openaire   +2 more sources