Results 81 to 90 of about 1,562 (203)

Polyethylene glycol (PEG-400) promoted as an efficient and recyclable reaction medium for the one-pot eco-friendly synthesis of functionalized isoxazole substituted spirooxindole derivatives

, 2017
An efficient, inexpensive and environmentally friendly synthesis of novel isoxazole substituted spirooxindole-pyridopyrimidine/indenopyridine/chromenopyridine/naphthyridine/quinoline derivatives has been developed.
Praveen Kumar Pittala, Nagi Reddy Modugu
core   +1 more source

In Vitro and In Silico Evaluation of Isatin‐Derived Spirooxindoles as Antituberculosis Drug Candidates

Chemical Biology &Drug Design, Volume 106, Issue 1, July 2025.
Two compounds, A16 and A17, were active against multidrug‐resistant Mycobacterium tuberculosis isolates (PT‐12 and PT‐20), overcoming key resistance mutations in katG and rpoB, while cytotoxicity assays confirmed that they are non‐toxic. A17 exhibited the highest antituberculosis activity, with molecular docking suggesting enoyl‐[acyl‐carrier‐protein ...
Fernanda Rodrigues de Lima, Jéssika de Oliveira Viana, Aleff Cruz de Castro, Rodrigo Cristiano, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso, Claudio Gabriel Lima‐Junior, Valnês da Silva Rodrigues‐Junior, Karen Cacilda Weber   +11 more
wiley   +1 more source

Efficient Multicomponent Synthesis of Spirooxindole Derivatives Catalyzed by Copper Triflate

, 2020
A simple and efficient method for the synthesis of spirooxindole derivatives via a three-component reaction of isatin, 5-aminopyrazole, and 1,3-dicarbonylcompounds (or β-​oxo-benzenepropanenitril​e) catalyzed by copper triflate in ethanol is described ...
Yu Lemao (8467434), Xi Meiyang (8467440), Jian Liu (33711), Xu Yingjie (8467437), Du Kui (8467431), Xiang Luo (108733), Runpu Shen (6757226), Chunlei Wu (9320)   +7 more
core   +1 more source

Passerini–Smiles Pathways to Spirooxindoles: Isatin-Based Scaffolds in Anticancer Drug Design

Chemistry
The underexplored Passerini–Smiles reaction (PSR), a variant of the 3-component Passerini reaction (3CPR), was successfully employed to create a tailored library of phenoxy-indoline carboxamide derivatives based on a fragment-based hybrid drug design ...
Carolina S. Marques, Aday González-Bakker, José M. Padrón   +2 more
doaj   +1 more source

A thermally-induced, tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition approach to carbocyclic spirooxindoles

Beilstein Journal of Organic Chemistry, 2010
The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
doaj   +1 more source

Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation

, 2016
Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation.
Chunliang Lu (1462417), Paul E. Floreancig (1555075), Qing Xiao (402996)   +2 more
core   +1 more source

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization

, 2017
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products.
Chengfeng Xia, Ting Wu, Zhiqiang Pan
core   +1 more source

Concise, Stereoselective Approach to the Spirooxindole Ring System of Citrinadin A

, 2016
The spirooxindole ring system of citrinadin A has been synthesized with excellent control over the absolute stereochemistry at the spirocenter. The key step involves a novel diastereoselective DMDO-mediated oxidative rearrangement employing an 8 ...
Daniel Knueppel (1371333), Stephen F. Martin (1338225), Martin Pettersson (1338222)   +2 more
core   +2 more sources

Organocatalytic [3 + 2] cycloaddition of oxindole-based azomethine ylides with 3-nitrochromenes: a facile approach to enantioenriched polycyclic spirooxindole-chromane adducts

, 2018
An organocatalytic asymmetric [3 + 2] cycloaddition of oxindole-based azomethine ylides with 3-nitro-2H-chromenes is reported, delivering densely functionalized polycyclic spirooxindole-chromane adducts.
Shiqiang Wei, Baomin Wang, Guodong Zhu, Jingping Qu, Hongbo Chen, Shiqi Wu   +5 more
core   +1 more source

Synthesis of Spirooxindole Oxetanes Through a Domino Reaction of 3‐Hydroxyoxindoles and Phenyl Vinyl Selenone

, 2019
An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl selenone with 3-hydroxyoxindoles under aqueous basic conditions at room temperature is described.
Martina Palomba, Luana Bagnoli, Luca Sancineto, Elisabetta Scarcella, Claudio Santi, Francesca Marini   +5 more
core   +1 more source