Results 81 to 90 of about 1,519 (173)

Chapter 1: Part A: A Unique Approach of Preparing 3,3-Disubstituted Oxindoles from Acyclic Tetrasubstituted Aldehydes: Total Synthesis of (-)-Coerulescine and (-)-Coixspirolactam A, Chapter 1: Part B: Synthetic Scope of Brønsted Acid Catalyzed Reactions of Carbonyl Compounds and Ethyl Diazoacetate, [PDF]

, 2021
CHAPTER 1: PART A: A UNIQUE APPROACH OF PREPARING 3,3-DISUBSTITUTED OXINDOLES FROM ACYCLIC TETRASUBSTITUTED ALDEHYDES: TOTAL SYNTHESIS OF (-)-COERULESCINE AND (-)-COIXSPIROLACTAM A(-)-Coerulescine and (-)-coixspirolactam A, two naturally occurring ...
Ali, Md Shahnawaz
core   +1 more source

Recent Advancements in the Cyclization Strategies of 1,3‐Enynes Towards the Synthesis of Heterocyclic/Carbocyclic Frameworks

Chemistry – An Asian Journal, Volume 20, Issue 8, April 17, 2025.
In this review, the advancements in the cyclization of 1,3‐enynes to construct structurally diverse heterocyclic and carbocyclic frameworks are portrayed comprehensively. Divergent cyclization protocols along with mechanistic aspects for key transformations are also detailed. Abstract 1,3‐Enynes have demonstrated their utility as valuable precursors to
Akash P. Sakla, Shams Aaghaz, Shujauddin Ahmed, Naziya Neshat, Ahmed Kamal   +4 more
wiley   +1 more source

5′-Benzylidene-1′′-methyl-4′′-phenyltrispiro[1,3-dioxolane-2,1′-cyclohexane-3′,3′′-pyrrolidine-2′′,3′′′-indole]-4′,2′′′-dione

IUCrData, 2017
In the title compound, C32H30N2O4, two spiro links connect the methyl-substituted pyrrolidine ring to the oxindole and cyclohexanone rings. The cyclohexanone ring is further connected to the dioxalane ring by a third spiro junction.
Kuppan Chandralekha, Deivasigamani Gavaskar, Adukamparai Rajukrishnan Sureshbabu, Srinivasakannan Lakshmi   +3 more
doaj   +1 more source

Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles [PDF]

Organic Letters, 2010
The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.
Bo, Liang, Srinivas, Kalidindi, John A, Porco, Corey R J, Stephenson   +3 more
openaire   +2 more sources

Cooperative Vinylogous Enamine and Metal Catalysis

ChemCatChem, Volume 17, Issue 7, April 4, 2025.
This review describes transformations combining vinylogous enamine catalysis with transition metal or Lewis acid catalysis that have emerged since the seminal report of dienamine catalysis in 2006. These transformations span numerous reaction classes, including alkylation, allylation, propargylation, oxyamination, dimerization, as well as cascade ...
Stacey E. Brenner‐Moyer
wiley   +1 more source

Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.
A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai, Áron Soma Németh, Zsolt Kelemen, Erika Bálint   +3 more
wiley   +1 more source

A Regioselective Multicomponent Approach for the Synthesis of Novel 2‐Acetyl‐4‐phenylquinoline Designed Monospiro‐Pyrrolidine and Thiapyrrolizidine Hybrids

Heteroatom Chemistry, Volume 2025, Issue 1, 2025.
A convenient approach for the synthesis of 2‐acetyl‐4‐phenylquinoline designed monospiro‐pyrrolidine/thiapyrrolizidine hybrids has been achieved via a 1,3‐dipolar cycloaddition reaction of various azomethine ylides derived from isatin/acenaphthylene‐1,2‐dione/ninhydrin, ortho‐phenylenediamine and sarcosine/L‐4‐thiazolidinecarboxylic acid with 2‐acetyl ...
Satheeshkumar Rajendran, Arul Murugesan, Shankar Ramasamy, Wangbin Wu   +3 more
wiley   +1 more source

Stereoselective N‐Heterocyclic‐Carbene‐Catalyzed Spiroannulation as an Access Towards Spirobenzofuranone‐Fused Cyclohexenones

Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.
Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška, Vojtěch Dočekal, Daniel Čermák, Simona Petrželová, Milan Pour, Ivana Císařová, Klára Konečná, Ondřej Janďourek, Jan Veselý   +8 more
wiley   +1 more source

Synthesis and cytotoxicity of 2’-benzoyl-1-benzyl-1 ‚- (4-fluorophenyl) -1’, 2 ‚, 5’, 6 ‚, 7’, 7a’-hexahydhydrospiro [indolin-3,3’-pyrrolyzine] -2-one [PDF]

, 2021
INTRODUCERE Este bine cunoscut faptul, că fragmentele oxindolice și pirolizidinice în multe cazuri, determină proprietăţile biologice ale substanţelor.
Bilan, Dmitrii, Cojocari, Sergiu, Gorincioi, Elena, Macaev, Fliur   +3 more
core  

Organocatalyzed Asymmetric Cascade Michael/Michael Reaction of α‐Alkylidene Succinimides with a 2‐(Trifluoromethylmethylene)indane‐1,3‐dione

European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.
A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki, Kosuke Nakashima, Yasuyuki Matsushima, Shin‐ichi Hirashima, Tsuyoshi Miura   +4 more
wiley   +1 more source