Results 81 to 90 of about 1,381 (201)

Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.
A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai, Áron Soma Németh, Zsolt Kelemen, Erika Bálint   +3 more
wiley   +1 more source

A general and efficient method to access tetracyclic spirooxindole derivatives.

, 2015
International audienceAn efficient, simple, and convenient synthetic procedure for the synthesis of tetracyclic spirooxindole derivatives, starting from N-protected isatins and 2-fluoropyridine, was successfully developed. It enables the facile formation
Troin, Yves, Abrunhosa-Thomas, Isabelle, Massip, Stéphane, Guillaumet, Gérald, Jarry, Christian, Bouakher, Abderrahman El   +5 more
core   +1 more source

Discovery, bioactivities and biosynthesis of spirooxindole alkaloids

Natural Product Reports
This review provides a comprehensive summary of the origin, activities, and biosynthesis of spirooxindole-containing alkaloids derived from a variety of organisms, including actinomycetes, cyanobacteria, fungi, plants, and invertebrates.
Ruijie Chen, Lihan Zhang, Xiaoyang Zhao, Zhuangjie Fang, Liping Zhang, Qingbo Zhang, Changsheng Zhang, Yiguang Zhu   +7 more
openaire   +2 more sources

Efficient Multicomponent Synthesis of Spirooxindole Derivatives Catalyzed by Copper Triflate

, 2020
A simple and efficient method for the synthesis of spirooxindole derivatives via a three-component reaction of isatin, 5-aminopyrazole, and 1,3-dicarbonylcompounds (or β-​oxo-benzenepropanenitril​e) catalyzed by copper triflate in ethanol is described ...
Yu Lemao (8467434), Xi Meiyang (8467440), Jian Liu (33711), Xu Yingjie (8467437), Du Kui (8467431), Xiang Luo (108733), Runpu Shen (6757226), Chunlei Wu (9320)   +7 more
core   +1 more source

Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines [PDF]

, 2014
A stereoselective cyclization between alkylidene oxindoles and 5-methoxyoxazoles has been developed using catalytic titanium(IV) chloride (as low as 5 mol %) to afford spiro[3,3'-oxindole-1-pyrrolines] in excellent yield (up to 99%) and ...
Badillo, Joseph J, Marilyn M. Olmstead, Annaliese K. Franz, Olmstead, Marilyn M, Ribeiro, Carlos JA, Carlos J. A. Ribeiro, Franz, Annaliese K, Joseph J. Badillo   +7 more
core   +1 more source

A thermally-induced, tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition approach to carbocyclic spirooxindoles

Beilstein Journal of Organic Chemistry, 2010
The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
doaj   +1 more source

Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1

, 2018
Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast.
Al-Majid, Abdullah Mohammed, Fardous F. El-Senduny, Hazem A. Ghabbour, Badria, Farid A., Ghabbour, Hazem A., Farid A. Badria, Barakat, Assem, Ghawas, Hussien Mansur, Abdullah Mohammed Al-Majid, Islam, Mohammad Shahidul, Yaseen A. M. M. Elshaier, El-Senduny, Fardous F., Hussien Mansur Ghawas, Elshaier, Yaseen A. M. M., Assem Barakat, Mohammad Shahidul Islam   +15 more
core   +1 more source

Catalyst free, multicomponent-tandem synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines: a glycerol mediated green approach

RSC Advances, 2015
The development of a versatile new one pot, catalyst free, multicomponent-tandem strategy for assembly of spirooxindole-indazolones and spirooxindole-pyrazolines is described.
Swastika Singh, Mohammad Saquib, Shyam Babu Singh, Mandavi Singh, Jagdamba Singh   +4 more
openaire   +1 more source

Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation

, 2016
Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation.
Chunliang Lu (1462417), Paul E. Floreancig (1555075), Qing Xiao (402996)   +2 more
core   +1 more source

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization

, 2017
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products.
Chengfeng Xia, Ting Wu, Zhiqiang Pan
core   +1 more source