Results 101 to 110 of about 1,519 (173)

Complete transfer of chirality in an intramolecular, thermal [2 + 2] cycloaddition of allene-ynes to form non-racemic spirooxindoles

Beilstein Journal of Organic Chemistry, 2011
A thermal [2 + 2] cycloaddition reaction of allene-ynes has been used to transform chiral non-racemic allenyl oxindoles into chiral non-racemic spirooxindoles containing an alkylidene cyclobutene moiety.
Kay M. Brummond, Joshua M. Osbourn
doaj   +1 more source

Asymmetric total syntheses of (+)- and (-)-spirotryprostatins A and B [PDF]

, 2003
2003 Spring.Includes bibliographical references.The first published total synthesis of (+)- and (-)-spirotryprostatin B is presented. The synthesis features an asymmetric azomethine ylide [1,3]-dipolar cycloaddition reaction.
Sebahar, Paul Richard
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Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

Frontiers in Pharmacology
This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Luis R. Domingo, Yaseen A. M. M. Elshaier   +8 more
doaj   +1 more source

Synthesis of 2-(hetero)arylquinazolinones in aqueous media [PDF]

, 2016
Fülöp Ferenc, Lázár László, Magyar Tímea, Miklós Ferenc   +3 more
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New spirooxindole-thiazolidine derivatives as antiseizure agents: Biological evaluation and computational studies

Results in Chemistry
Background: Oxindoles and spirooxindoles are considered privileged scaffolds in medicinal chemistry due to their diverse biological activities, which include anticonvulsant, anticancer, and antimicrobial properties.
Leila Emami, Leila Moezi, Pegah Mardaneh, Sara Sadeghian, Elaheh Ataollahi, Masoumeh Divar, Sahar Zarei, Saeed Agah, Razieh Sabet, Soghra Khabnadideh   +9 more
doaj   +1 more source

Corrigendum: Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Frontiers in Oncology, 2023
Qian Zhao, Shan-Shan Xiong, Can Chen, Can Chen, Hong-Ping Zhu, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han   +9 more
doaj   +1 more source

Hydroxyapatite/PCL/Fe3O4 waste-based composite: An efficient green catalyst for spirooxindole-chromene synthesis under ultrasonic irradiation

Case Studies in Chemical and Environmental Engineering
Hydroxyapatite (HAp) derived from bioresources has garnered attention due to its advantageous catalytic capabilities. In this study, HAp was synthesized from green mussel shell waste and subsequently composited with Fe3O4 for utilization as a catalyst in
Agus Rimus Liandi, Renita Wulan Sari, Tio Putra Wendari, Imelda, Dwi Febriantini, Andon Insani   +5 more
doaj   +1 more source

Microwave-Assisted Green Synthesis of Spiroindolinopyranopyrazoles [PDF]

Green Chemistry, usually known as sustainable chemistry, is widely implemented worldwide to safeguard human health and the environment. Recent investigations in organic synthesis and chemical transformation have demonstrated that green chemistry ...
Owusu, Esther
core   +1 more source

Corrigendum: A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

Frontiers in Chemistry, 2019
Joana D. Amaral, Dário Silva, Cecília M. P. Rodrigues, Susana Solá, Maria M. M. Santos   +4 more
doaj   +1 more source

Synthesis and anticancer potential of combretastatin sulfonamide/sulfonates, quinazolinone derivatives and green synthesis of spirooxindole, pyrazolo-pyrimidine derivatives [PDF]

, 2017
RASALA, MAHESH
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