Results 101 to 110 of about 1,562 (203)

Corrigendum: A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

Frontiers in Chemistry, 2019
Joana D. Amaral, Dário Silva, Cecília M. P. Rodrigues, Susana Solá, Maria M. M. Santos   +4 more
doaj   +1 more source

Asymmetric Synthesis of Multicyclic Spirooxindole Derivatives Bearing Stereogenic Quaternary Carbon Atoms

An organocatalyzed stereoselective domino reaction as a facile approach to multicyclic spirooxindole derivatives bearing two stereogenic quaternary carbon atoms is reported. The alkyl-substituted chiral thiourea catalyst was efficient for the reaction to
Rong Zhang (44942), Weijun Yao (1689823), Zhen Wang (72451), Xiaoyi Li (669720), Yonghui Zhang (279832), Zhen Zhou (184390), Zihao Li (4239886), Yi Xia (294184)   +7 more
core   +1 more source

Novel Spirooxindole-Benzofuran Scaffold: Potential Inhibition Against Hepatocellular Carcinoma by Targeting MDM2-p53 Interaction

We synthesized a novel compound library featuring a spirooxindole core structure combined with various heterocycles, including benzofuran, benzothiophene, and thiophene scaffolds.
Alayyaf, Abdulmajeed Abdullah, Domling, Alexander, Al-Muhanna, Muhanna K., Ul-Haq, Zaheer, Badria, Farid A., El-Senduny, Fardous F., Barakat, Assem, Islam, Mohammad Shahidul, Ali, M., Zia, Komal   +9 more
core   +1 more source

Spirooxindole Derivatives as Emerging Scaffolds in Drug Discovery: Synthetic Strategies, Structure-Activity Relationship, and Biological Activities. [PDF]

ChemMedChem
Kalita RC, Bezbaruah S, Patle D.
europepmc   +1 more source

Dynamic stereoselective annulation via aldol-oxa-cyclization cascade reaction to afford spirooxindole pyran polycycles [PDF]

Spiro polycyclic compounds bearing pyran ring systems are found in bioactive molecules, and we recently reported the construction of spirooxindole all-carbon polycycles.
Sohail, Muhammad, Tanaka, Fujie
core   +1 more source

Evaluation of novel 1,4-dihydropyridine spirooxindole as antitumor, anti-inflammatory, and antioxidant agents. [PDF]

RSC Adv
Al-Afghani EH, Zahra JA, El-Abadelah MM, Jaber AM, Kasabri V.   +4 more
europepmc   +1 more source

Pyrrolidine-Based Antifungal Agents Against <i>Candida</i> Species: A Systematic Review of Structure-Activity Relationships and Mechanistic Insights from Experimental Studies. [PDF]

Pharmaceuticals (Basel)
Sinchan HG, Chaithra N, Umamaheshwari S.
europepmc   +1 more source

Recent advances of azomethine ylides for the synthesis of natural and synthetic bioactive pyrrolidines and spiropyrrolidines. [PDF]

RSC Adv
Paira P, Chakrabarty R, Deb Barman P, Singh B, Paira R.   +4 more
europepmc   +1 more source

Enantioselective cyclization reactions involving 3-isothiocyanato oxindoles: synthesis of spirocycles. [PDF]

RSC Adv
Edareh MH, Doraghi F, Farahani A, Ghasemi M, Mahdavi M.   +4 more
europepmc   +1 more source

Oxidative Rearrangement of Indoles Enabled by Promiscuous Cryptic Halogenation with Vanadium-Dependent Haloperoxidases. [PDF]

ACS Catal
Lee HJ, Brzezinski CU, Solis SA, Semenick RS, Galindo AV, Barthel SG, Bacsa J, Biegasiewicz KF.   +7 more
europepmc   +1 more source