Results 91 to 100 of about 1,381 (201)

Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines

, 2015
A stereoselective cyclization between alkylidene oxindoles and 5-methoxyoxazoles has been developed using catalytic titanium­(IV) chloride (as low as 5 mol %) to afford spiro­[3,3′-oxindole-1-pyrrolines] in excellent yield (up to 99%) and ...
Joseph J. Badillo (1347651), Annaliese K. Franz (1289460), Carlos J. A. Ribeiro (1347654), Marilyn M. Olmstead (1306137)   +3 more
core   +1 more source

Screening of spirooxindole derivatives for anti-tumor activity on melanoma cells.

, 2013
(A) Structure of analogues SOID-1 to SOID-12 inspired by natural product Sprotryprostatin B. (B) Effect of spirooxindole derivatives on melanoma cell growth.
Sangkil Nam (298303), Fumiko Yakushijin (298307), Yuelong Ma (298310), David Horne (298311), Kenichi Yakushijin (298308), Yan Tian (298301), Ralf Buettner (298309), Fan Yang (1413), Lucy Liu (298305), Wei Liang (26352), Richard Jove (198900)   +10 more
core   +1 more source

Construction of Tetracyclic 3‑Spirooxindole through Cross-Dehydrogenation of Pyridinium: Applications in Facile Synthesis of (±)-Corynoxine and (±)-Corynoxine B

, 2016
A facile and straightforward method was developed to construct the fused tetracyclic 3-spirooxindole skeleton, which exists widely in natural products.
Xu Deng (1688152), Yu-Chen Liu (405361), Jun Xu (45543), Li-Dong Shao (1393552), Chengfeng Xia (266690), Dashan Li (1688155), Qin-Shi Zhao (1647877)   +6 more
core   +1 more source

Asymmetric Synthesis of Multicyclic Spirooxindole Derivatives Bearing Stereogenic Quaternary Carbon Atoms

An organocatalyzed stereoselective domino reaction as a facile approach to multicyclic spirooxindole derivatives bearing two stereogenic quaternary carbon atoms is reported. The alkyl-substituted chiral thiourea catalyst was efficient for the reaction to
Rong Zhang (44942), Weijun Yao (1689823), Zhen Wang (72451), Xiaoyi Li (669720), Yonghui Zhang (279832), Zhen Zhou (184390), Zihao Li (4239886), Yi Xia (294184)   +7 more
core   +1 more source

Formal (4+1) Cycloaddition and Enantioselective Michael-Henry Cascade Reactions To Synthesize Spiro[4,5]decanes and Spirooxindole Polycycles

, 2017
Spiro[4,5]decanes and polycyclic compounds bearing spiro[4,5]decane systems are important biofunctional molecules. Described are diastereoselective formal (4+1) cycloaddition reactions to afford oxindole‐functionalized spiro[4,5]decanes and ...
Muhammad Sohail, Huang, Ji-Rong, Monde, Kenji, Taniguchi, Tohru, Sohail, Muhammad, Tohru Taniguchi, Kenji Monde, Tanaka, Fujie, Ji-Rong Huang, Fujie Tanaka   +9 more
core   +1 more source

Enantioselective Construction of Tetrahydroquinolin-5-one-Based Spirooxindole Scaffold via an Organocatalytic Asymmetric Multicomponent [3 + 3] Cyclization

, 2016
The first catalytic enantioselective construction of biologically important tetrahydroquinolin-5-one-based spirooxindole has been developed via a chiral cinchona alkaloid catalyzed asymmetric three-component [3 + 3] cyclization of cyclic enaminone ...
Yu-Chen Zhang (1426030), Xiao-Xue Sun (3071418), Feng Shi (305643), Qiu-Ning Zhu (1426033), Meng-Meng Xu (1507912), Xue Yang (144876)   +5 more
core   +1 more source

New spirooxindole-thiazolidine derivatives as antiseizure agents: Biological evaluation and computational studies

Results in Chemistry
Background: Oxindoles and spirooxindoles are considered privileged scaffolds in medicinal chemistry due to their diverse biological activities, which include anticonvulsant, anticancer, and antimicrobial properties.
Leila Emami, Leila Moezi, Pegah Mardaneh, Sara Sadeghian, Elaheh Ataollahi, Masoumeh Divar, Sahar Zarei, Saeed Agah, Razieh Sabet, Soghra Khabnadideh   +9 more
doaj   +1 more source

Hydroxyapatite/PCL/Fe3O4 waste-based composite: An efficient green catalyst for spirooxindole-chromene synthesis under ultrasonic irradiation

Case Studies in Chemical and Environmental Engineering
Hydroxyapatite (HAp) derived from bioresources has garnered attention due to its advantageous catalytic capabilities. In this study, HAp was synthesized from green mussel shell waste and subsequently composited with Fe3O4 for utilization as a catalyst in
Agus Rimus Liandi, Renita Wulan Sari, Tio Putra Wendari, Imelda, Dwi Febriantini, Andon Insani   +5 more
doaj   +1 more source

Synthesis of Spirooxindole Oxetanes Through a Domino Reaction of 3‐Hydroxyoxindoles and Phenyl Vinyl Selenone

, 2019
An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl selenone with 3-hydroxyoxindoles under aqueous basic conditions at room temperature is described.
Martina Palomba, Luana Bagnoli, Luca Sancineto, Elisabetta Scarcella, Claudio Santi, Francesca Marini   +5 more
core   +1 more source

Corrigendum: Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Frontiers in Oncology, 2023
Qian Zhao, Shan-Shan Xiong, Can Chen, Can Chen, Hong-Ping Zhu, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han   +9 more
doaj   +1 more source