Results 91 to 100 of about 1,562 (203)

(Z)-3′-(3-Chloro-4-fluorophenyl)-5-fluoro-5′-((6-methoxypyridin-3-yl)methylene)spiro[indoline-3,2′-thiazolidine]-2,4′-dione

Molbank
A novel spiro[indoline-3,2′-thiazolidine]-2,4′-dione derivative incorporating 3-chloro-4-fluorophenyl and 6-methoxypyridin-3-yl fragments was synthesized and characterized.
Dominika Kuceł, Jarosław Sobstyl, Serhii Holota, Dmytro Khylyuk   +3 more
doaj   +1 more source

A Diastereoselective Mizoroki-Heck Reaction for Synthesis of Spirooxindole-Based Nonnatural Amino Acids Using a Boc-Protected Amine Chiral Auxiliary

Nonnatural amino acids are pivotal for expanding the functional diversity of peptides and proteins, enabling novel therapeutic opportunities. Mono-Boc-protected spirocyclization precursors have been developed as versatile intermediates for the ...
Puthiyaparambath, Sharathna, Larhed, Mats, Odell, Luke R., Lindman, Jens, Gising, Johan, Gising, Johan,, Lindman, Jens,, Puthiyaparambath, Sharathna,, Odell, Luke R.,, Larhed, Mats,   +9 more
core   +1 more source

Latest developments of spirooxindoles and their derivatives in medicinal chemistry

Future Medicinal Chemistry
Spirooxindoles represent a pivotal class of heterocyclic compounds known for their diverse and potent biological activities. Naturally occurring spirooxindoles have been isolated from medicinal plants such as Flueggea virosa and Mitragyna speciosa, inspiring extensive research into their synthetic analogs.
Firoj, Hassan, , Nadimullah, Sabahat Yasmeen, Sheikh, Iqbal, Azad, Malik, Nasibullah   +4 more
openaire   +2 more sources

A C₁-symmetric N-heterocyclic carbene catalysed oxidative spiroannulation of isatin-derived enals: highly enantioselective synthesis of spirooxindole δ-lactones

, 2018
A NHC-catalysed spiroannulation of isatin-derived enals and 1,3-dicarbonyl compounds has been developed, enabling enantioselective synthesis of synthetically important spirooxindole δ-lactones.
Xi-Na Cheng, Xiao-Dong Tian, Jun-Bing Lin, Yong-Chun Luo, Guo-Qiang Xu, Peng-Fei Xu   +5 more
core   +1 more source

Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif

, 2016
The efficient assembly of hydroindane derivatives incorporating a spirooxindole motif was realized via a new three-component domino reaction of (E)-4-(1-methyl-2-oxoindolin-3-ylidene)-3-oxobutanoates and two molecules of α,β-unsaturated aldehydes under ...
Kun Jiang (166885), Ying-Chun Chen (712090), Xiang Yin (1447678), Li Wu (120770), Zhi-Jun Jia (2213686)   +4 more
core   +1 more source

Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules

Frontiers in Pharmacology
This study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Matti Haukka, Marwa M. Abu-Serie, Alexander Dömling, Luis R. Domingo, Yaseen A. M. M. Elshaier   +8 more
doaj   +1 more source

Titanium(IV)-Catalyzed Stereoselective Synthesis of Spirooxindole-1-pyrrolines

, 2015
A stereoselective cyclization between alkylidene oxindoles and 5-methoxyoxazoles has been developed using catalytic titanium­(IV) chloride (as low as 5 mol %) to afford spiro­[3,3′-oxindole-1-pyrrolines] in excellent yield (up to 99%) and ...
Joseph J. Badillo (1347651), Annaliese K. Franz (1289460), Carlos J. A. Ribeiro (1347654), Marilyn M. Olmstead (1306137)   +3 more
core   +1 more source

Collective chemical syntheses of spirooxindole alkaloids

Spirooxindole alkaloids and their derivatives exhibit excellent biological activities in different aspects bearing a potential of pharmaceutical application. Many synthetic chemists were attracted to synthesize this type of compounds efficiently.
Cheung, Yuen Tsz
core  

Screening of spirooxindole derivatives for anti-tumor activity on melanoma cells.

, 2013
(A) Structure of analogues SOID-1 to SOID-12 inspired by natural product Sprotryprostatin B. (B) Effect of spirooxindole derivatives on melanoma cell growth.
Sangkil Nam (298303), Fumiko Yakushijin (298307), Yuelong Ma (298310), David Horne (298311), Kenichi Yakushijin (298308), Yan Tian (298301), Ralf Buettner (298309), Fan Yang (1413), Lucy Liu (298305), Wei Liang (26352), Richard Jove (198900)   +10 more
core   +1 more source

Corrigendum: Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Frontiers in Oncology, 2023
Qian Zhao, Shan-Shan Xiong, Can Chen, Can Chen, Hong-Ping Zhu, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han   +9 more
doaj   +1 more source