The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation
PharmaceuticalsThe p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the ...
Adel S. Girgis +8 more
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Corrigendum to “Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma” [PDF]
This is a critical needed correction. In Fig. 15, the image corresponding to the lung from mouse treated with 25 mg/kg was taken from the same section of the mouse that was treated with 10 mg/kg. The corrected Fig. 15 [Formula presented] Fig.
Abu-Serie, Marwa M. +9 more
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Synthesis and study of spirooxindols with anti-HIV activity [PDF]
, 2021 INTRODUCERE Conform unui număr mare de publicaţii spirooxindoli au proprietăţi biologice diferite printre care se numără și activitatea anti-HIV [1, 2].
Sucman, Natalia
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Синтез і антимікробна активність гексаметилен-N-малеїнімідопохідних спіроіндол- 3,3’-піроло[3,4-с]піролу [PDF]
, 2017 Aim. To synthesize a series of hexamethylene-N-maleinimidospiroindole-3,3’-pyrrolo[3,4-c]pyrrole derivatives, study the antimicrobial activity of the compounds synthesized and compare their antimicrobial activity with the antimicrobial activity of the ...
Filimonova, N. I. +4 more
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Synthetic applications of the meta photocycloaddition reaction [PDF]
, 2010 The meta photocycloaddition between a substituted aryl ring and alkene affords architecturally complex tricylic intermediates that have been utilised to investigate three different areas of synthetic organic chemistry.
Berritt, Simon
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Beilstein Journal of Organic Chemistry, 2010 The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
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Synthesis of the pentacyclic carbon framework of the PF1270 family of natural products, The [PDF]
, 2014 2014 Summer.Includes bibliographical references.The PF1270 family of natural products contains novel indole alkaloids that display interesting biological activity; the synthesis of these natural products and their analogs could lead to the discovery of ...
Sanchez, Michelle A.
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Spirooxadiazoline oxindoles: synthesis and evaluation of anticancer and antimalarial activities [PDF]
, 2017 Cancer is one of the modern world’s most common and deadly non-infectious disease. According to WHO Cancer Report of 2015, it is one of leading causes of morbidity and mortality worldwide with 8.8 million deaths in 2015 and it is expected to rise about ...
Lopes, Elizabeth de Abreu
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Ligandos multidiana relacionados con productos naturales para el tratamiento potencial de enfermedades neurodegenerativas [PDF]
, 2020 Neurodegenerative diseases are characterized by the loss of neurons in the brain and/or spinal cord and constitute one of the most important health problems worldwide.
Cores Esperón, Ángel
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ACTIVITY OF DABCO: CATALYTIC SCOPE IN ORGANIC SYNTHESIS [PDF]
, 2017 1,4-DiAzaBiCyclo[2.2.2.]octane (DABCO) is a good neucleophile and base in number of organic reactions and gaining particular importance as catalyst in synthetic organic chemistry. Catalytic applications of DABCO in various reactions such as cycloaddition
Saikia, Pallabi
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