Results 61 to 70 of about 1,519 (173)
Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation [PDF]
Organic Letters, 2010 Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit.
Chunliang, Lu +2 more
openaire +2 more sources
Gold catalyzed multicomponent reactions beyond A3 coupling [PDF]
, 2018 The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity.
Gimeno, M.C. +3 more
core +2 more sources
Molecules, 2018 A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents.
Liqiang Wu, Yunxia Liu, Yazhen Li
doaj +1 more source
Organocatalyzed Asymmetric Reaction Using α-Isothiocyanato Compounds [PDF]
, 2016 Organocatalyzed asymmetric reaction using α-isothiocyanato compounds has received much attention in the past 5 years, and significant progress has been made for three types of isothiocyanato compounds, including α-isothiocyanato amides, esters, and ...
Chen, Yong-Zheng +4 more
core +2 more sources
Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines [PDF]
Molecules, 2017 This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates. The asymmetric induction is secured by an organocatalytic strategy, exploiting a bifunctional cinchona-
Rainoldi, Giulia +4 more
openaire +3 more sources
Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction
Beilstein Journal of Organic Chemistry, 2013 A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst ...
Qin Fu, Chao-Guo Yan
doaj +1 more source
Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions
ChemSusChem, Volume 18, Issue 14, July 17, 2025.This study presents sodium bicarbonate (NaHCO3) as a safe, solid source of CO2 for mechanochemical carboxylation reactions. Mechanochemical methods for synthesizing cyclic carbamates and organic carbonates from NaHCO3 are developed. This approach holds significant potential for pharmaceutical applications, highlighting solvent‐minimized synthesis and ...
Francesco Mele +11 more
wiley +1 more source
Expanding the chemical diversity of spirooxindoles via alkylative pyridine dearomatization
Beilstein Journal of Organic Chemistry, 2012 A mild and practical synthesis of spirooxindole [1,3]oxazino derivatives from N-substituted isatins and 1,3-dicarbonyl compounds with pyridine derivatives is reported. The reactions provided good to excellent yields.
Chunhui Dai +2 more
doaj +1 more source