Results 61 to 70 of about 1,562 (203)

Sequential Multicomponent Strategy for the Diastereoselective Synthesis of Densely Functionalized Spirooxindole-Fused Thiazolidines [PDF]

, 2018
We developed two Ugi-type three-component reactions of spirooxindole-fused 3-thiazolines, isocyanides, and either carboxylic acids or trimethylsilyl azide, to give highly functionalized spirooxindole-fused thiazolidines.
Ruijter, Eelco; id_orcid, De Munnik, Mariska, Giulia Rainoldi, Vande Velde, Christophe M. L.,, Orru, Romano; id_orcid, Christophe M. L. Vande Velde, Lo Presti, Leonardo, Lesma, Giordano,, Rainoldi, Giulia,, Ruijter, Eelco, Mariska de Munnik, Giordano Lesma, Leonardo Lo Presti, Vande Velde, Christophe M.L., Lesma, Giordano, Silvani, Alessandra,, Ruijter, Eelco,, Silvani, Alessandra, Vande Velde, Christophe M. L., Alessandra Silvani, Eelco Ruijter, Orru, Romano, Begnini, Fabio,, Orru, Romano,, Fabio Begnini, Lo Presti, Leonardo,, Romano Orru, Rainoldi, Giulia, de Munnik, Mariska,, BEGNINI, FABIO   +29 more
core   +1 more source

Synthesis and Structure Elucidation of Novel Spirooxindole Linked to Ferrocene and Triazole Systems via [3 + 2] Cycloaddition Reaction

Molecules, 2022
In the present work, a novel heterocyclic hybrid of a spirooxindole system was synthesized via the attachment of ferrocene and triazole motifs into an azomethine ylide by [3 + 2] cycloaddition reaction protocol.
Mezna Saleh Altowyan, Saied M. Soliman, Matti Haukka, Nora Hamad Al-Shaalan, Aminah A. Alkharboush, Assem Barakat   +5 more
doaj   +1 more source

Biosynthetically‐Inspired Oxidative Cleavage Platform Enables Rapid Access to Diverse and Architecturally Complex Chemotypes From Indole Alkaloids

ChemistryEurope, Volume 4, Issue 4, April 2026.
We report a biosynthesis‐inspired ring distortion approach that involves oxidative ring cleavage, ring rearrangement, and ring expansion reactions from a diverse collection of indole alkaloids and derivatives. This chemical synthesis approach led to the synthesis of >25 distinct chemotypes from 14 indole alkaloids.
Derek A. Leas, Eli S. Levit, Alexis A. Bragg, Taylor A. Gerrein, Khalil A. Abboud, Pingrong Wei, Lukasz M. Dobrzycki, Robert W. Huigens III   +7 more
wiley   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Highly Stereoselective Brønsted Acid Catalyzed Synthesis of Spirooxindole Pyrans

, 2016
A Brønsted acid-catalyzed Prins-type cyclization sequence to construct spirooxindole pyrans in high yields and excellent diastereoselectivity has been developed.
Jingqi Wang (748537), Erika A. Crane (2191495), Karl A. Scheidt (493484)   +2 more
core   +2 more sources

Facile synthesis of functionalized spiro[indoline-3,2'-oxiran]-2-ones by Darzens reaction

Beilstein Journal of Organic Chemistry, 2013
A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst ...
Qin Fu, Chao-Guo Yan
doaj   +1 more source

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

Molecules, 2018
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents.
Liqiang Wu, Yunxia Liu, Yazhen Li
doaj   +1 more source

Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1

, 2018
Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast.
Al-Majid, Abdullah Mohammed, Fardous F. El-Senduny, Hazem A. Ghabbour, Badria, Farid A., Ghabbour, Hazem A., Farid A. Badria, Barakat, Assem, Ghawas, Hussien Mansur, Abdullah Mohammed Al-Majid, Islam, Mohammad Shahidul, Yaseen A. M. M. Elshaier, El-Senduny, Fardous F., Hussien Mansur Ghawas, Elshaier, Yaseen A. M. M., Assem Barakat, Mohammad Shahidul Islam   +15 more
core   +1 more source

Next‐Generation Proteolysis‐Targeting Chimeras in Precision Oncology: Multifunctional Designs, Emerging Modalities, and Translational Prospects in Targeted Protein Degradation

Drug Development Research, Volume 86, Issue 8, December 2025.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs)‐mediated protein degradation has been recently developed as a game‐changing approach in oncology drug development. It represents a paradigm shift from traditional enzyme inhibition to selective protein degradation.
Mohamed S. Nafie, Mohamed K. Diab, Asmaa S. A. Yassen, Amany M. Elshamy, Mohamed R. El Tohamy, Haytham O. Tawfik, Sherif Ashraf Fahmy   +6 more
wiley   +1 more source

DMAP-Promoted Cascade Synthesis of Bispirooxindole–Cyclopentene–Isoxazolones

Molecules
A DMAP-catalyzed Michael addition/cyclization cascade reaction has been developed for the efficient construction of a bispirooxindole–cyclopentene–isoxazolone framework. Under the optimized conditions (10 mol% DMAP, CH2Cl2, room temperature), the desired
Wei Zhang, Rong-Rong Zhu, Da-Ming Du
doaj   +1 more source