Results 21 to 30 of about 1,381 (201)

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic
Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna   +7 more
doaj   +1 more source

Tri(n-butyl)phosphine-promoted domino reaction for the efficient construction of spiro[cyclohexane-1,3'-indolines] and spiro[indoline-3,2'-furan-3',3''-indolines]

Beilstein Journal of Organic Chemistry, 2022
The tri(n-butyl)phosphine-catalyzed reaction of isatylidene malononitriles and bis-chalcones in chloroform at 65 °C afforded functionalized spiro[cyclohexane-1,3'-indolines] in good yields and with good diastereoselectivity.
Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan   +3 more
doaj   +1 more source

Transition metal-catalyzed synthesis of spirooxindoles

RSC Advances, 2021
Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyzed synthesis of spirooxindoles.
P. V. Saranya, Mohan Neetha, Thaipparambil Aneeja, Gopinathan Anilkumar   +3 more
openaire   +3 more sources

Drug Repurposing of Lactoferrin Combination in a Nanodrug Delivery System to Combat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Dr. Sulaiman Al Habib Medical Journal, 2021
A drug repurposing approach for Food and Drug Administration (FDA)-approved drugs and preclinical entity by using cheminformatics and chemical transformational method, with the objective of discovering safer novel potent inhibitors that are selective for
Assem Barakat, Abdullah Mohammed Al-Majid, Gehad Lotfy, Mohamed Ali, Ahmed Mostafa, Yaseen A.M.M. Elshaier   +5 more
doaj   +1 more source

Construction of diazepine-containing spiroindolines via annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates

Beilstein Journal of Organic Chemistry, 2023
A straightforward synthetic protocol for the efficient construction of diazepine-containing spiroindolines has been developed and proceeds through a by base-promoted annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates.
Xing Liu, Wenjing Shi, Jing Sun, Chao-Guo Yan   +3 more
doaj   +1 more source

[3+2] Cycloaddition Reaction for the Stereoselective Synthesis of a New Spirooxindole Compound Grafted Imidazo[2,1-b]thiazole Scaffold: Crystal Structure and Computational Study

Crystals, 2021
A new spirooxindole hybrid engrafted imidazo[2,1-b]thiazole core structure was designed and achieved via [3+2] cycloaddition reaction approach. One multi-component reaction between the ethylene derivative based imidazo[2,1-b]thiazole scaffold with 6-Cl ...
Mezna Saleh Altowyan, Saied M. Soliman, Matti Haukka, Nora Hamad Al-Shaalan, Aminah A. Alkharboush, Assem Barakat   +5 more
doaj   +1 more source

Titanocene(III)-Mediated 5‑exo-trig Radical Cyclization: En Route to Spirooxindole-Based Tetrahydrofuran and Bicyclic Lactone

, 2019
The isatin core system is of immense importance due to the highly reactive prochiral C-3 position, which paves an easy way to construct large arrays of spirooxindole heterocyclic motifs. Herein, we depict an isatin-derived and 3,3′-disubstituted oxindole-
Jothi Lakshmi Nallasivam, Tushar Kanti Chakraborty, Jothi Lakshmi Nallasivam (8113865), Tushar Kanti Chakraborty (1790794)   +3 more
core   +4 more sources

DataSheet_1_Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold.docx

, 2023
Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Khoa Chung (14562038), Zhicheng Xia (3005628), Trinh-Don Nguyen (8519445), Dagny Grzech (12904781), Tuan-Anh M. Nguyen (14562035), Thu-Thuy T. Dang (8519451)   +5 more
core   +1 more source

The Synthesis of 3-Spirooxindole Derivatives. IV. The Conversion of 3-Spirooxindole to Indole Derivative.

Chemical and Pharmaceutical Bulletin, 1963
The conversion of 1-methylspiro (indoline-3, 1'-indolizine)-2-one to 12-methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine is described as a preliminary for the chemical correlation of N-methylrhynchophyllane with N-methyldihydrocorynantheane.
Oishi, Takeshi, Maeno, Shizuo, Ban, Yoshio   +2 more
openaire   +3 more sources

Therapeutic Potential of Spirooxindoles as Antiviral Agents [PDF]

ACS Infectious Diseases, 2016
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug ...
Na, Ye, Haiying, Chen, Eric A, Wold, Pei-Yong, Shi, Jia, Zhou   +4 more
openaire   +2 more sources