Results 11 to 20 of about 1,562 (203)

[Bmim]Br Accelerated One-Pot Three-Component Cascade Protocol for the Construction of Spirooxindole–Pyrrolidine Heterocyclic Hybrids

Molecules, 2020
Our synthetic approach for the assembly of structurally complex spirooxindole heterocyclic hybrids was based on an ionic liquid, [bmim]Br mediated one-pot three-component cascade reaction strategy involving 1,3-dipolar cycloaddition reaction of N-1-(2 ...
Raju Suresh Kumar, Dhaifallah M. Al-thamili, Abdulrahman I. Almansour, Natarajan Arumugam, Necmi Dege   +4 more
doaj   +2 more sources

Organocatalytic Asymmetric Synthesis of Spirooxindole Embedded Oxazolidines

The Journal of Organic Chemistry, 2021
The first organocatalytic asymmetric synthesis of spirooxindole embedded oxazolidines has been developed via a domino reaction involving hemiaminal formation, followed by an unprecedented aza-Michael reaction between isatin derived N-Boc ketimines and γ-hydroxy enones.
Chandrakanta Parida, Buddhadeb Mondal, Animesh Ghosh, Subhas Chandra Pan   +3 more
openaire   +3 more sources

Catalytic Asymmetric Synthesis of gem‐Dicyano‐Spirocyclopropyl Oxindoles by N‐9‐Anth‐PyBidine‐Co(OAc)2: Advantage of Three‐Component Coupling Approach

ChemistryEurope
A chiral N‐9‐Anth‐PyBidine‐Co(OAc)2 complex catalyzed the kinetically controlled asymmetric Michael/alkylation reaction of 3‐chlorooxindoles with alkylidenemalononitriles to give gem‐dicyano‐spirocyclopropyl oxindoles in a highly diastereo‐ and ...
Takaaki Saito, Ren Miyasaka, Kazumasa Kon, Yuri Takagi, Takayoshi Arai   +4 more
doaj   +2 more sources

Spirooxindole 5-(Trifluoromethyl)benzothiazole Hybrids: Synthesis, Crystal Structure, and Antioxidant Activity. [PDF]

Arch Pharm (Weinheim)
The antioxidant activities of novel 5‐(trifluoromethyl)‐3H‐spiro[1,3‐benzothiazole‐2,3′‐indol]‐2′(1′H)‐ones (4a–h), along with the previously synthesized spirocyclic 2‐indolinones (4i–m and 5a–n), were investigated to find a multi‐modal antioxidant and to understand the impact of the trifluoromethyl group located at the 5‐position of the benzothiazole ...
Karabag N, Temizer-Keser AB, Pekmez M, Mertoğlu-Kamalı E, Kaynak FB, Özsoy N, Arda N, Karalı N.   +7 more
europepmc   +2 more sources

Spirooxindoles as Disruptors of Preformed Hen Egg White Lysozyme Fibrils as a Model for Neurodegenerative Diseases. [PDF]

ChemMedChem
Formation of fibrils is a key factor in the development of neurodegenerative diseases. Their highly ordered structure is stabilized by strong hydrogen bonding. Synthesised spirooxindole compounds, Hd‐63, Hd‐66, and Hd‐74, disrupt fibril structure, leading to the breakdown of this order and promoting the formation of off‐pathway aggregates that lack ...
Dahdah A, de Silva NH, Blanch EW, Maniam S.   +3 more
europepmc   +2 more sources

Electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives as inhibitors of acetylcholinesterase. [PDF]

BMC Chem
Abstract An efficient, reliable, and cost-effective approach was applied for the electrochemical synthesis of spirooxindole-pyranopyrazole and spirooxindole-chromene derivatives. The compounds were prepared in high yields and short reaction times by electrochemical synthesis using LiClO 4
Elsapagh RM, Osman EO, Hafez AM, El-Nassan HB.   +3 more
europepmc   +3 more sources

Access to Spirooxindole-Fused Cyclopentanes via a Stereoselective Organocascade Reaction Using Bifunctional Catalysis

, 2023
The present study reports an asymmetric organocascade reaction of oxindole-derived alkenes with 3-bromo-1-nitropropane efficiently catalyzed by the bifunctional catalyst. Spirooxindole-fused cyclopentanes were produced in moderate-to-good isolated yields
Vojtěch Dočekal (11160300), Simona Petrželová (14514489), Jan Veselý (1843195), Andrea Vopálenská (11160303), Ivana Císařová (1580947)   +4 more
core   +3 more sources

Pd-Catalyzed Asymmetric Dearomative Heck/Tsuji-Trost Difunctionalization of Naphthalenes. [PDF]

Adv Sci (Weinh)
We have developed a palladium‐catalyzed asymmetric dearomative Heck/Tsuji‐Trost 1,4‐difunctionalization reaction of naphthalenes, affording 4‐aminospirocyclohexene oxindole products bearing two remote chiral centers. Through the effect of the newly designed chiral sulfinamide phosphine ligand with large steric hindrance, side reactions are inhibited ...
Ma LL, Xu B, Zhang J, Zhang ZM.
europepmc   +2 more sources

Access to Spirooxindole-fused Cyclopentanes via Stereoselective Organocascade Reaction using Bifunctional Catalysis [PDF]

, 2022
The present study reports an asymmetric organocascade reaction of oxindole-derived alkenes with 3-bromo-1-nitropropane efficiently catalyzed by the bifunctional catalyst. Spirooxindole-fused cyclopentanes were produced in moderate-to-good isolated yields
Simona, Petrželová, Jan, Veselý, Ivana, Císařová, Andrea, Vopálenská, Vojtěch, Dočekal   +4 more
core   +2 more sources

Substrate-Controlled Regioselectivity Switchable [3 + 2] Annulations To Access Spirooxindole Skeletons

, 2022
The additive-free [3 + 2] annulation from isatins, amino acids with 2-styrylbenzoxazoles, was described, providing a series of functional and structurally complex 3,3′-pyrrolidinyl-spirooxindole derivatives containing four contiguous and two quaternary ...
Zhan-Yong Wang (1581079), Kai-Kai Wang (1402588), Rongxiang Chen (736801), Ning-Bo Li (739480), Shan Gu (11409039), Lu−Lu Zhang (1816288), Yan-Li Li (244012)   +6 more
core   +2 more sources