Results 31 to 40 of about 8,159 (220)

Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles

Molecules, 2021
A series of novel S-, O- and Se-containing dispirooxindole derivatives has been synthesized using 1,3-dipolar cycloaddition reaction of azomethine ylide generated from isatines and sarcosine at the double C=C bond of 5-indolidene-2-chalcogen-imidazolones
Maksim Kukushkin, Vladimir Novotortsev, Vadim Filatov, Yan Ivanenkov, Dmitry Skvortsov, Mark Veselov, Radik Shafikov, Anna Moiseeva, Nikolay Zyk, Alexander Majouga, Elena Beloglazkina   +10 more
doaj   +1 more source

Synthesis of spiropyrrolizidines containing quinoxaline and pyrrole fragments [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023
The reaction of 1,3-dipolar cycloaddition azomethine ylides obtained by the in situ interaction of 11H-indeno[1,2-b]quinoxalin-11-one and proline, and 3-phenyl-1-pyrrolyl-2-en-1-ones has been used for the synthesis of substituted spiropyrrolizidines in ...
Borisova, Svetlana Vasilievna, Sorokin, Vitaly Viktorovich, Klochkova, Irina N.   +2 more
doaj   +1 more source

Stereoselective synthesis of fused tetrahydroquinazolines through one-pot double [3 + 2] dipolar cycloadditions followed by [5 + 1] annulation

Beilstein Journal of Organic Chemistry, 2016
The one-pot [3 + 2] cycloaddition of an azomethine ylide with a maleimide followed by another [3 + 2] cycloaddition of an azide with the second maleimide gives a 1,5-diamino intermediate which is used for a sequential aminomethylation reaction with ...
Xiaofeng Zhang, Kenny Pham, Shuai Liu, Marc Legris, Alex Muthengi, Jerry P. Jasinski, Wei Zhang   +6 more
doaj   +1 more source

Synthesis and Characterization of New Spirooxindoles Including Triazole and Benzimidazole Pharmacophores via [3+2] Cycloaddition Reaction: An MEDT Study of the Mechanism and Selectivity

Molecules, 2023
A new series of spirooxindoles based on benzimidazole, triazole, and isatin moieties were synthesized via a [3+2] cycloaddition reaction protocol in one step. The single X-ray crystal structure of the intermediate triazole-benzimidazole 4 was solved. The
Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, M. Ali, Mezna Saleh Altowyan, Mar Ríos-Gutiérrez, Sammer Yousuf, Assem Barakat   +7 more
doaj   +1 more source

Highly diastereoselective 1,3-dipolar cycloaddition of nonstabilized azomethine ylides to 3-nitro-2-trihalomethyl-2H-chromenes: Synthesis of 1-benzopyrano[3,4-c]pyrrolidines [PDF]

, 2013
Reactions of 3-nitro-2-trifluoro(trichloro)methyl-2H-chromenes, including 2-unsubstituted derivatives, with N-alkyl-α-amino acids (sarcosine, proline) and paraformaldehyde proceed diastereoselectively to give 1-benzopyrano[3,4-c]pyrrolidines in good ...
Barkov, A. Y., Kodess, M. I., Korotaev, V. Y., Matochkina, E. G., Moshkin, V. S., Sosnovskikh, V. Y.   +5 more
core   +1 more source

Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides [PDF]

, 2014
Catalytic asymmetric 1,3-dipolar cycloadditions of azomethine ylides have turned out to be one of the most efficient methods for the preparation of enantioenriched pyrrolidines.
Adrio, Javier, Carretero, Juan C.
core   +2 more sources

Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(II) and copper(II) complex [PDF]

, 2017
A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides.
Aboudzadeh, Ali, Bittner, Alexander J., Cossío Mora, Fernando Pedro, De Cózar Ruano, Abel, Eleta-Lopez, Aitziber, Hernandez, Frank J., Miranda, José I., Rivilla de la Cruz, Iván, Santos, José I., Schäfer, Thomas   +9 more
core   +2 more sources

Triethylamine-Promoted Oxidative Cyclodimerization of 2H-Azirine-2-carboxylates to Pyrimidine-4,6-dicarboxylates: Experimental and DFT Study

Molecules, 2023
An unprecedented oxidative cyclodimerization reaction of 2H-azirine-2-carboxylates to pyrimidine-4,6-dicarboxylates under heating with triethylamine in air is described. In this reaction, one azirine molecule undergoes formal cleavage across the C-C bond
Timofei N. Zakharov, Pavel A. Sakharov, Mikhail S. Novikov, Alexander F. Khlebnikov, Nikolai V. Rostovskii   +4 more
doaj   +1 more source

Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes [PDF]

, 2014
This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective ...
Nájera, Carmen, Sansano, Jose M.
core   +2 more sources

Benzotriazolylmethylaminosilanes: Novel azomethine ylide equivalents

Tetrahedron, 1994
Abstract Benzotriazolylmethylaminosilanes, readily accessible from the reaction of benzotriazole, an aldehyde and an (aminomethyl)silane in water at 20°C, are azomethine ylide equivalents which undergo stereospecific cycloadditions with dipolarophiles to give substituted pyrrolidines or 2,5-dihydropyrroles in good yields.
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, FL 32611-7200 USA ( host institution ), R. Katritzky, Alan, Köditz, Jens, Lang, Hengyuan   +3 more
openaire   +2 more sources