A Novel One-Pot Green Synthesis of Dispirooxindolo-pyrrolidines via 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides [PDF]
Molecules, 2015 A facile synthesis of dispirooxindolopyrrolidines has been accomplished via a one-pot three component 1,3-dipolar cycloaddition reaction. The reaction of azomethine ylides generated in situ from L-phenylalanine and substituted isatins with a series of ...
Abdulrahman I. Almansour +5 more
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Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone [PDF]
Beilstein Journal of Organic Chemistry, 2014 1,3-Dipolar cycloadditions of isatins, benzylamine and benzylideneacetones were studied to prepare a series of novel spiropyrrolidine-oxindoles – 4′-acetyl-3′,5′-diarylspiro[indoline-3,2′-pyrrolidin]-2-ones and 3′-acetyl-4′,5′-diarylspiro[indoline-3,2 ...
Chuqin Peng +5 more
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Glycine-Based [3+2] Cycloaddition for the Synthesis of Pyrrolidine-Containing Polycyclic Compounds [PDF]
MoleculesThe synthesis of pyrrolidine compounds with biological interest is an active research topic. Glycine could be a versatile starting material for making pyrrolidine derivatives.
Tieli Zhou +3 more
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Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework [PDF]
BMC ChemistryHybridization of spirooxindole with different pharmacophores such as triazole and heterocycle such as thiophene and furan moiety was achieved by the [3 + 2] cycloaddition (32CA) reaction approach. Structural investigations of the compounds 4a and 4b were
Abdulmajeed Abdullah Alayyaf +7 more
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Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors. [PDF]
ChemMedChem, 2019 Gollner A +14 more
europepmc +3 more sources
Catalyst-Free [3+2] Cycloaddition of Electron-Deficient Alkynes and o‑Hydroxyaryl Azomethine Ylides in Water [PDF]
ACS Omega, 2020 Jin Zhu +5 more
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One-Step Maleimide-Based Dual Functionalization of Protein N-Termini. [PDF]
Angew Chem Int Ed EnglMaleimides can target the N‐termini of proteins instead of cysteine by the use of 2‐pyridinecarboxaldehyde and copper(II) salt under non‐denaturing conditions. The methodology requires no mutagenesis of proteins and enables the high‐yield attachment of various functional groups to proteins with various N‐terminal amino acids through a simple operation ...
Hanaya K, Taguchi K, Wada Y, Kawano M.
europepmc +3 more sources
Covalent Organic Functionalization of Graphene Nanosheets and Reduced Graphene Oxide via 1,3-Dipolar Cycloaddition of Azomethine Ylide [PDF]
Nanoscale Advances, 3, 2021, 5841-5852, 2021 Organic functionalization of graphene is successfully performed via 1,3-dipolar cycloaddition of azomethine ylide in the liquid phase. The comparison between 1-methyl-2-pyrrolidinone and N,N-dimethylformamide as dispersant solvents, and between sonication and homogenization as dispersion techniques, proves N,N-dimethylformamide and homogenization as ...
arxiv +1 more source
Deterministic Covalent Organic Functionalization of Monolayer Graphene with 1,3-Dipolar Cycloaddition Via High Resolution Surface Engineering [PDF]
J. Mater. Chem. C 11 (2023) 2630 - 2639, 2022 Spatially-resolved organic functionalization of monolayer graphene is successfully achieved by combining low-energy electron beam irradiation with 1,3-dipolar cycloaddition of azomethine ylide. Indeed, the modification of the graphene honeycomb lattice obtained via electron beam irradiation yields to a local increase of the graphene chemical reactivity.
arxiv +1 more source
Substituted proline derivatives as organocatalysts in Michael reaction [PDF]
Journal of the Serbian Chemical Society, 2014 Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, have been studied as organocatalysts in Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10
Jovanović Predrag +5 more
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