Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone [PDF]
Beilstein Journal of Organic Chemistry, 2014 1,3-Dipolar cycloadditions of isatins, benzylamine and benzylideneacetones were studied to prepare a series of novel spiropyrrolidine-oxindoles – 4′-acetyl-3′,5′-diarylspiro[indoline-3,2′-pyrrolidin]-2-ones and 3′-acetyl-4′,5′-diarylspiro[indoline-3,2 ...
Chuqin Peng +5 more
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Diastereodivergent Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides and β-Fluoroalkyl Vinylsulfones: Low Copper(II) Catalyst Loading and Theoretical Studies [PDF]
Angewandte Chemie, 2019 We have developed Cu(II)-catalyzed asymmetric 1,3-dipolar cycloadditions using β-fluoroalkyl alkenyl arylsulfones as dipolarophiles and glycine/alanine iminoesters as azomethine ylide precursors.
Cheng, Feng +7 more
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Glycine-Based [3+2] Cycloaddition for the Synthesis of Pyrrolidine-Containing Polycyclic Compounds [PDF]
MoleculesThe synthesis of pyrrolidine compounds with biological interest is an active research topic. Glycine could be a versatile starting material for making pyrrolidine derivatives.
Tieli Zhou +3 more
doaj +2 more sources
Catalyst-Free [3+2] Cycloaddition of Electron-Deficient Alkynes and o‑Hydroxyaryl Azomethine Ylides in Water [PDF]
ACS Omega, 2020 Jin Zhu +5 more
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Targeted Synthesis of Complex Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-ones by Intramolecular Cyclization of Azomethine Ylides: Highly Potent MDM2-p53 Inhibitors. [PDF]
ChemMedChem, 2019 Gollner A +14 more
europepmc +3 more sources
Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework [PDF]
BMC ChemistryHybridization of spirooxindole with different pharmacophores such as triazole and heterocycle such as thiophene and furan moiety was achieved by the [3 + 2] cycloaddition (32CA) reaction approach. Structural investigations of the compounds 4a and 4b were
Abdulmajeed Abdullah Alayyaf +7 more
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Chemistry, 2023 Asymmetric [3+2] cycloaddition reactions are fascinating and powerful methods for the synthesis of enantioenriched pyrrolidines up to four stereocentres. Pyrrolidines are important compounds for both biology and organocatalytic applications.
S. Kumar, P. Guiry
semanticscholar +1 more source
Asymmetric 1,3-Dipolar Cycloadditons of Stabilized Azomethine Ylides with Nitroalkenes [PDF]
, 2014 This review highlights the biological importance of many polysubstituted nitro-prolines and -pyrrolidines. Their preparation using asymmetric 1,3-dipolar cycloadditions of azomethine ylides with nitroalkenes using diastereoselective and enantioselective ...
Nájera, Carmen, Sansano, Jose M.
core +2 more sources
Substituted proline derivatives as organocatalysts in Michael reaction [PDF]
Journal of the Serbian Chemical Society, 2014 Chiral, polysubstituted proline esters, obtained via cycloaddition reactions of azomethine ylides, have been studied as organocatalysts in Michael reaction of aldehydes/ketones and vinylsulphones. Under optimised reaction conditions employing 10
Jovanović Predrag +5 more
doaj +1 more source
Synthesis of Chromen[4,3-b]pyrrolidines by Intramolecular 1,3-Dipolar Cycloadditions of Azomethine Ylides: An Experimental and Computational Assessment of the Origin of Stereocontrol [PDF]
, 2015 Azomethine ylides, generated from imine-derived O-cinnamyl or O-crotonyl salicylaldeyde and α-amino acids, undergo intramolecular 1,3-dipolar cycloaddition, leading to chromene[4,3-b]pyrrolidines.
Arrieta, Ana +8 more
core +2 more sources