Progastrin Promotes Colorectal Cancer Stem Cell‐Like Properties via the Receptor PZR
Advanced Science, Volume 12, Issue 38, October 13, 2025.The tumor microenvironment supports colorectal cancer (CRC) progression by maintaining cancer stem cells (CSCs) through progastrin (PG). This study identifies Protein Zero‐Related protein (PZR) as an essential receptor for PG activity, promoting CSC‐like signaling via SHP2/SRC/β‐catenin.
Julie Nguyen +22 more
wiley +1 more source
Effects of Phytic Acid Extracted From Rice Bran on Azoxymethane-Induced Colon Carcinogenesis in Rats [PDF]
, 2008 This research is carried out to study the potential of phytic acid extracted from rice bran in the suppression of colon carcinogenesis in rats. In the optimization of phytic acid extraction, results showed 5% H2S04 in pH 0.6 and 30 minutes of extraction
Saad, Norazalina
core
Red wine and pomegranate extracts suppress cured meat promotion of colonic mucin-depleted foci in carcinogen-induced rats [PDF]
, 2017 Processed meat intake is carcinogenic to humans. We have shown that intake of a workshop-made cured meat with erythorbate promotes colon carcinogenesis in rats.
Bastide, Nadia +9 more
core +5 more sources
Chromatin Laser Imaging Reveals Abnormal Nuclear Changes for Early Cancer Detection
, 2018 We developed and applied rapid scanning laser-emission microscopy to detect abnormal changes in cell nuclei for early diagnosis of cancer and cancer precursors.
Aslam, Muhammad Nadeem +6 more
core +1 more source
Signalling Pathways Implicated in Obesity Associated Cancers [PDF]
, 2014 Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.Peer reviewedPublisher ...
Drew, Janice E.
core +1 more source
Journal of Nutrition & Intermediary Metabolism, 2019 Cancer is one of the most important causes of mortality in the world. General methods for cancer treatment have many side effects, while biological treatments such as probiotics consumption not only have no undesirable effects, but also are more ...
Zahra Heydari +2 more
doaj +1 more source
Functional anthocyanin-rich sausages diminish colorectal cancer in an animal model and reduce pro-inflammatory bacteria in the intestinal microbiota [PDF]
, 2018 Colorectal cancer is the fourth most common neoplasia in Europe, where it accounts for 28.2 new cases per 100,000 inhabitants. In an effort to decrease the incidence of this disease, various prevention measures are being studied, one of which are ...
Fernández Fernández, Javier +4 more
core +3 more sources
Hepatic repercussions of azoxymethane-induced colorectal carcinogenesis.
Revista do Colegio Brasileiro de Cirurgioes, 2014 To evaluate the hepatic effects of colonic carcinogenesis induced by azoxymethane at different doses and times of exposure in rats.Forty-four Wistar rats were divided into four groups. The animals were eight weeks at the beginning of the experiment. group 1 received 1.0 ml of saline intraperitoneally once a week for two weeks. Group 2 received 15 mg/kg
Idália Maria Brasil, Burlamaqui +8 more
openaire +1 more source
Fermented wheat germ extract - nutritional supplement or anticancer drug? [PDF]
, 2011 Background Fermented wheat germ extract (FWGE) is a multisubstance composition and, besides others, contains 2-methoxy benzoquinone and 2, 6-dimethoxy benzoquinone which are likely to exert some of its biological effects.
Thomas Mueller, Wieland Voigt
core +1 more source
Mda level in colon tissue of the rats with colon cancer model treated with diallyl disulfide [PDF]
Eurasian Journal of Veterinary SciencesAim: This study was conducted to investigate the effect of diallyl disulfide, one of the bioactive compounds of garlic, on the malondialdehyde level of colon tissue in rats with azoxymethane-induced colon cancer. Materials and Methods: A total of 58 male
Beyza Suvarikli Alan, Zafer Bulut
doaj