Results 81 to 90 of about 15,703 (232)

Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol

Biology
Hepatic encephalopathy (HE) is a neurological condition linked to liver failure. Acute HE (Type A) occurs with acute liver failure, while chronic HE (Type C) is tied to cirrhosis and portal hypertension. HE treatments lag due to gaps in understanding its
Xiao Y. Tong, Hussain Hussain, Nagarajarao Shamaladevi, Michael D. Norenberg, Aya Fadel, Omar El Hiba, El got Abdeljalil, Bilal El-Mansoury, Deepak Kempuraj, Sampath Natarajan, Andrew V. Schally, Miklos Jaszberenyi, Luis Salgueiro, Michael J. Paidas, Arumugam R. Jayakumar   +14 more
doaj   +1 more source

Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice. [PDF]

PLoS ONE, 2013
Obesity is an important risk factor for colon cancer in humans, and numerous studies have shown that a high fat diet enhances colon cancer development.
Iina Tuominen, Leina Al-Rabadi, Dimitris Stavrakis, Iordanis Karagiannides, Charalabos Pothoulakis, James M Bugni   +5 more
doaj   +1 more source

Activins and their related proteins in colon carcinogenesis: insights from early and advanced azoxymethane rat models of colon cancer [PDF]

, 2016
BACKGROUND: Activin-A may exert pro- or anti-tumorigenic activities depending on cellular context. However, little is known about its role, or the other mature activin proteins, in colorectal carcinoma (CRC). This study measured the expression of activin
Adel Galal El-Shemi, Amr Mohamed Mohamed, Bassem Refaat, Jawwad Ahmad, Osama Adnan Kensara, Shakir Idris   +5 more
core   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

The KDM6B/SLC10A2 Axis Suppresses MDSCs Recruitment via ERK/AP‐1 Signaling in Colorectal Cancer

Advanced Science, Volume 13, Issue 9, 13 February 2026.
In wild‐type intestinal epithelial cells, KDM6B demethylates SLC10A2 to promote its expression, after which SLC10A2 suppresses ERK phosphorylation, inhibiting AP‐1 (Fos/Jun) transcription and chemokine production. In KDM6B‐deficient intestinal epithelial cells, SLC10A2 methylation increases, and its expression decreases.
Zhibo Hu, Jing Xun, Bin Liu, Xiaolin Jiang, Yingdi Han, Huichao Yang, Qi Gao, Ruifang Gao, Aimin Zhang, Xueliang Wu, Dapeng Zhang, Dihua Li, Tian Li, Shimin Yang, Ximo Wang, Xiangyang Yu, Qi Zhang   +16 more
wiley   +1 more source

Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis in the colon of AOM-treated rat

Journal of Experimental & Clinical Cancer Research, 2008
Background To evaluate the relationship between Aberrant Crypt Foci (ACF) and tumorigenesis, we observed the sequential development from ACF to tumor in the colon of azoxymethane-exposed wistar rats. Methods Sixty wistar rats were sacrificed at different
Lin Chen, Jiang Bo, Lu Qing, Shan Tao
doaj   +1 more source

The role of intestinal microflora and probiotic bacteria in prophylactic and development of colorectal cancer [PDF]

, 2013
The gut microbiota comprises a large and diverse range of microorganisms whose activities have a significant impact on health. It interacts with its host at both the local and systemic level, resulting in a broad range of beneficial or detrimental ...
Dagmara Złotkowska, Ewa Wasilewska, Mariola E. Pijagin   +2 more
core   +1 more source

Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer

BMC Research Notes, 2018
Objectives (3R)-Falcarinol (FaOH) and (3R,8S)-falcarindiol (FaDOH) have previously been shown to reduce the number of neoplastic lesions and the growth rate of polyps in the colon of azoxymethane (AOM) treated rats.
Morten Kobaek-Larsen, Dennis Sandris Nielsen, Witold Kot, Łukasz Krych, Lars Porskjær Christensen, Gunnar Baatrup   +5 more
doaj   +1 more source

Polyethylene glycol and prevalence of colorectal adenomas : Population-based study of 1165 patients undergoing colonoscopy [PDF]

, 2006
Background and aim — Dietary polyethylene glycol (PEG) is extraordinarily potent in the chemoprevention of experimental colon carcinogenesis. PEG is used to treat constipation in France and in the USA. French laxatives include Forlax® (PEG4000), Movicol®
Barbieux, Jean-Pierre, Bertrand, Philippe, Bougnoux, Philippe, Brondin, Brigitte, Corpet, Denis E., Dorval, Etienne, Jankowski, Jean Marie, Viguier, Jérôme   +7 more
core  

Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

Asian Pacific Journal of Cancer Prevention, 2013
In recent years, due to modern lifestyles and exposure to chemical carcinogens, cancer cases are steadily increasing. From this standpoint, azoxymethane (AOM), a chemical carcinogen which causes de novo liver damage, and resveratrol, which is an antioxidant found in foods and protects against oxidative stress damage, are of interest.
Gürocak S., Karabulut E., Karadag N., Ozgor D., Ozkeles N., Bay Karabulut A.   +5 more
openaire   +5 more sources