Results 81 to 90 of about 10,720 (219)

Dark Aberrant Crypt Foci with activated Wnt pathway are related to tumorigenesis in the colon of AOM-treated rat

Journal of Experimental & Clinical Cancer Research, 2008
Background To evaluate the relationship between Aberrant Crypt Foci (ACF) and tumorigenesis, we observed the sequential development from ACF to tumor in the colon of azoxymethane-exposed wistar rats. Methods Sixty wistar rats were sacrificed at different
Lin Chen, Jiang Bo, Lu Qing, Shan Tao
doaj   +1 more source

Targeting the NAT1‐ENO1‐Lactate Axis Destabilizes PD‐L1 to Reinvigorate Antitumor Immunity in Colorectal Cancer

MedComm, Volume 7, Issue 8, August 2026.
NAT1 downregulates PD‐L1 protein expression by acetylating ENO1, which inhibits lactate‐fueled TRAF6/PD‐L1 signaling (left). Conversely, NAT1 deficiency in CRC cells enhances ENO1 activation, leading to increased glycolysis and lactate production. The lactate then binds to TRAF6, promoting its oligomerization and activation.
Yi‐Xuan Liu, Wen‐Xin Wu, Yang Zang, Guang Hu, Xin Guo, Yi Wang, Yun Yang, Zhi Jiang, Xiu‐Ming Li, Feng Liu, Yue‐Yue Wu, Zu‐Da Pan, Yuan‐Meng Hu, Ruo‐Yang Zhang, Hai‐Yi Zhang, Ping‐An Chang, Xiao‐Shun He, Wen‐Juan Gan, Hua Wu   +18 more
wiley   +1 more source

Meat and cancer: haemoglobin and haemin in a low calcium diet promote colorectal carcinogenesis at the aberrant crypt stage in rats [PDF]

, 2003
High intake of red meat, but not of white meat, is associated with an increased risk of colon cancer. However, red meat does not promote cancer in rodents.
Denis E. Corpet, Petit, Claude, Pierre, Fabrice, van Der Meer, Roelof, Van der Meer, Roleof, Claude R. Petit, Pierre, Fabrice H.F., Taché, Sylviane, Fabrice Pierre, Corpet, Denis E., Roelof Van Der Meer, Petit, Claude R   +11 more
core   +1 more source

Effect of the dietary polyacetylenes falcarinol and falcarindiol on the gut microbiota composition in a rat model of colorectal cancer

BMC Research Notes, 2018
Objectives (3R)-Falcarinol (FaOH) and (3R,8S)-falcarindiol (FaDOH) have previously been shown to reduce the number of neoplastic lesions and the growth rate of polyps in the colon of azoxymethane (AOM) treated rats.
Morten Kobaek-Larsen, Dennis Sandris Nielsen, Witold Kot, Łukasz Krych, Lars Porskjær Christensen, Gunnar Baatrup   +5 more
doaj   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Lactobacillus johnsonii Suppresses Colorectal Cancer in Association With Intestinal Statine Enrichment and Tumor Cell Apoptosis

Food Frontiers, Volume 7, Issue 4, July 2026.
Lactobacillus johnsonii (LJ) demonstrates prophylactic and therapeutic activity against colorectal tumors in AOM/DSS and MC38 murine models. Integrative microbiome, metabolomic, and transcriptomic analyses associate LJ treatment with TNF‐related signaling, apoptotic gene programs, and increased intestinal statine (STA).
Shengwei Chen, LiZhuowen Yan, Jingtao Zeng, Yikun Chen, Xinyuan Zhao, Wei Meng, Jionghan Zhuang, Fengying Chen, Yonglong Guo, A. M. Abd El‐Aty, Xianghong Ju, Shihua Yang   +11 more
wiley   +1 more source

Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice

Journal of Neuroinflammation, 2019
Background Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated due to liver failure in
Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Elaina Williams, Brandi Jefferson, Alison Thomas, Ankita Brahmaroutu, Sharon DeMorrow   +8 more
doaj   +1 more source

The Allium cepa Derived Compound Propyl Propane Thiosulfonate (PTSO) Improves Tumorigenesis Due to Its Immunomodulatory Effect: A Preclinical Study

Phytotherapy Research, Volume 40, Issue 7, Page 4124-4146, July 2026.
In vitro and in vivo effects of PTSO in colorectal cancer preclinical models, highlighting antiproliferative, pro‐apoptotic, barrier‐enhancing, antitumor, prebiotic and immunomodulatory properties. Created using BioRender. ABSTRACT Allium‐derived organosulfur compounds offer significant health benefits.
María Jesús Rodríguez‐Sojo, Laura Hidalgo‐García, Jose Alberto Molina‐Tijeras, Laura López‐Escanez, Luckman Gbati, Teresa Vezza, Patricia Diez‐Echave, Antonio Jesús Ruiz‐Malagón, Jorge García‐García, Federico García, Alberto Baños, Lidia Gil‐Martínez, Rocío López‐Posadas, Markus F. Neurath, Julio Gálvez, María Elena Rodríguez‐Cabezas, Alba Rodríguez‐Nogales   +16 more
wiley   +1 more source

Beef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium [PDF]

, 2007
Red meat consumption is associated with increased risk of colorectal cancer. We have previously shown that haemin, Hb and red meat promote carcinogen-induced preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF) in rats.
Santarelli, Raphaëlle, L., Pierre, Fabrice, Pierre, Fabrice H.F., Taché, Sylviane, Guéraud, Françoise, Santarelli, Raphaëlle L., Corpet, Denis E.   +6 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source