Results 61 to 70 of about 10,720 (219)
Inhibitory Effect of Silibinin against Azoxymethane-Induced Colon Tumorigenesis in A/J Mice
, 2010 Purpose: Colorectal cancer is the second leading cause of cancer-associated deaths, which suggests that more effort is needed to prevent/control this disease.
Mallikarjuna Gu +4 more
core +1 more source
Gut MicrobesThe insights into interactions between host genetics and gut microbiome (GM) in colorectal tumor susceptibility (CTS) remains lacking. We used Collaborative Cross mouse population model to identify genetic and microbial determinants of Azoxymethane ...
Dan Li +10 more
doaj +1 more source
Cell Proliferation, EarlyView.In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar +5 more
wiley +1 more source
Gut microbiota mediated the toxicity of high concentration of dietary nitrite in C57BL/6 mice
Ecotoxicology and Environmental Safety, 2022 Growing evidence indicates that exposure to high levels of nitrite for a prolonged time has adverse health effects. Although gut microbiota is responsible for the transformation of nitrite in the gut, the evidence concerning whether gut microbiota ...
Jing Xu +5 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang +5 more
wiley +1 more source
The effects of diallyl disulfide on certain oxidative stress and biochemical parameters in an azoxymethane-induced colon cancer model [PDF]
Eurasian Journal of Veterinary SciencesThe aim of the present study is to investigate the effects of diallyl disulfide (DADS), an active compound of garlic, on certain serum biochemical and oxidative stress parameters in colon cancer induced by azoxymethane (AOM) in rats.
Buse Turan +2 more
doaj
Journal of Dairy Science: Colorectal cancer (CRC) arises from the accumulation of abnormal mutations in colorectal cells during prolonged inflammation. This study aimed to investigate the potential of probiotic fermented milk containing the probiotic strain, Bifidobacterium ...
Chengcong Yang +6 more
doaj +1 more source
Discovery of cancer-preventive juices reactivating RB functions
Environmental Health and Preventive Medicine, 2023 Background: Recent advances have been achieved in the genetic diagnosis and therapies against malignancies due to a better understanding of the molecular mechanisms underlying carcinogenesis.
Mitsuharu Masuda +7 more
doaj +1 more source
Cell Biology International, Volume 50, Issue 8, August 2026.ABSTRACT Berberine (BBR), a natural alkaloid, exhibits potent anti‐tumor activity in colorectal cancer (CRC), but its mechanisms are not fully elucidated. Analysis of GEO datasets (GSE216908 and GSE184414) identified WDR54 as a key target of BBR treatment. In vitro, BBR treatment of CRC cell lines (HT‐29 and SW480) markedly inhibited cell proliferation,
Qin Chen, Qi Chen, Fenqiong Tang
wiley +1 more source
Carbohydrate Digestibility Predicts Colon Carcinogenesis in Azoxymethane-Treated Rats
Nutrition and Cancer, 2006 The purpose of this study was to compare the effect of carbohydrate structure and digestibility on azoxymethane (AOM)-induced colon carcinogenesis. Five groups of male Fischer 344 rats each comprising 30 animals were injected with AOM and fed a high-fat diet with 15% of various carbohydrates.
Jacobsen, Helene +5 more
openaire +2 more sources