Results 51 to 60 of about 8,111 (184)

Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer

Journal of Dairy Science
: Colorectal cancer (CRC) arises from the accumulation of abnormal mutations in colorectal cells during prolonged inflammation. This study aimed to investigate the potential of probiotic fermented milk containing the probiotic strain, Bifidobacterium ...
Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen   +6 more
doaj   +1 more source

Discovery of cancer-preventive juices reactivating RB functions

Environmental Health and Preventive Medicine, 2023
Background: Recent advances have been achieved in the genetic diagnosis and therapies against malignancies due to a better understanding of the molecular mechanisms underlying carcinogenesis.
Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai   +7 more
doaj   +1 more source

Orthotopic Esophageal Cancer Xenograft Model in Immunosuppressed Microminipigs for Near‐Infrared Fluorescence Endoscopy

Cancer Science, Volume 117, Issue 6, Page 1678-1689, June 2026.
We report the first successful orthotopic engraftment of human esophageal squamous cell carcinoma in immunosuppressed microminipigs and demonstrate high‐contrast near‐infrared fluorescence endoscopic detection using EGFR‐targeted cetuximab. This large‐animal model bridges preclinical imaging research and future clinical translation in esophageal cancer.
Takanori Miyake, Yutaka Kawano, Takanori Kashihara, Masaki Takasu, Kentaroh Takagaki, Shota Fujimoto, Tomoyuki Kawaguchi, Kaizo Kagemoto, Yoshifumi Kida, Koichi Okamoto, Masahiro Sogabe, Naoki Muguruma, Koichi Tsuneyama, Yasushi Sato, Tetsuji Takayama   +14 more
wiley   +1 more source

Decoding the Hexosamine Biosynthesis Pathway: Implications for Novel Therapeutic Strategies in Sarcoma

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
ABSTRACT Cancer cells rewire their metabolism to sustain a high proliferation rate. Sensing external cues is essential to match the metabolic fluxes of the cells to the external stimuli. As part of the glucose metabolism, the hexosamine biosynthesis pathway (HBP) is considered a nutrient‐sensing pathway. The HBP produces UDP‐GlcNAc, a key precursor for
Pegah Rahimizadeh, Richard Miallot, Chelsea De Bellis, Philippe Jolivet, Joanna Przybyl   +4 more
wiley   +1 more source

Carbohydrate Digestibility Predicts Colon Carcinogenesis in Azoxymethane-Treated Rats

Nutrition and Cancer, 2006
The purpose of this study was to compare the effect of carbohydrate structure and digestibility on azoxymethane (AOM)-induced colon carcinogenesis. Five groups of male Fischer 344 rats each comprising 30 animals were injected with AOM and fed a high-fat diet with 15% of various carbohydrates.
Jacobsen, Helene, Poulsen, Morten, Dragsted, Lars Ove, Ravn-Haren, Gitte, Meyer, Otto, Lindecrona, Rikke Hvid   +5 more
openaire   +2 more sources

Age and Sex in the Development of Hepatic Encephalopathy: Role of Alcohol

Biology
Hepatic encephalopathy (HE) is a neurological condition linked to liver failure. Acute HE (Type A) occurs with acute liver failure, while chronic HE (Type C) is tied to cirrhosis and portal hypertension. HE treatments lag due to gaps in understanding its
Xiao Y. Tong, Hussain Hussain, Nagarajarao Shamaladevi, Michael D. Norenberg, Aya Fadel, Omar El Hiba, El got Abdeljalil, Bilal El-Mansoury, Deepak Kempuraj, Sampath Natarajan, Andrew V. Schally, Miklos Jaszberenyi, Luis Salgueiro, Michael J. Paidas, Arumugam R. Jayakumar   +14 more
doaj   +1 more source

A Probiotic Combination of Limosilactobacillus reuteri and Clostridium butyricum Ameliorates 5‐Fluorouracil‐Induced Intestinal Mucositis in Rats by Strengthening Barrier Integrity and Modulating Immuno‐Microbial Homeostasis

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
A probiotic formulation of Limosilactobacillus reuteri and Clostridium butyricum provides prophylactic protection against 5FU‐induced mucositis by strengthening the intestinal barrier, reshaping the microbiota to reduce pathogenic load, and regulating immune‐inflammatory response via TLR4‐mediated pathway.
Pui‐Ying Leong, Wen‐Chen Chuang, Jiunn‐Liang Ko, Jiunn‐Wang Liao, Liang‐Chuan Chen, Yi‐Hsuan Tsai, Chu‐Chyn Ou   +6 more
wiley   +1 more source

Diet-induced obesity promotes colon tumor development in azoxymethane-treated mice. [PDF]

PLoS ONE, 2013
Obesity is an important risk factor for colon cancer in humans, and numerous studies have shown that a high fat diet enhances colon cancer development.
Iina Tuominen, Leina Al-Rabadi, Dimitris Stavrakis, Iordanis Karagiannides, Charalabos Pothoulakis, James M Bugni   +5 more
doaj   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Inhibition by isoproterenol and neostigmine of experimental carcinogenesis in rat colon by azoxymethane [PDF]

British Journal of Cancer, 1988
Inhibition by isoproterenol and neostigmine of experimental carcinogenesis in rat colon by ...
M, Tatsuta, H, Iishi, H, Yamamura, M, Baba, H, Taniguchi   +4 more
openaire   +2 more sources