Results 31 to 40 of about 8,111 (184)

Uncoupled nitric oxide synthase activity promotes colorectal cancer progression

Frontiers in Oncology, 2023
Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than
Asim Alam, Steven C. Smith, Sundaresan Gobalakrishnan, Mina McGinn, Vasily A. Yakovlev, Christopher S. Rabender   +5 more
doaj   +1 more source

The Allium cepa Derived Compound Propyl Propane Thiosulfonate (PTSO) Improves Tumorigenesis Due to Its Immunomodulatory Effect: A Preclinical Study

Phytotherapy Research, EarlyView.
In vitro and in vivo effects of PTSO in colorectal cancer preclinical models, highlighting antiproliferative, pro‐apoptotic, barrier‐enhancing, antitumor, prebiotic and immunomodulatory properties. Created using BioRender. ABSTRACT Allium‐derived organosulfur compounds offer significant health benefits.
María Jesús Rodríguez‐Sojo, Laura Hidalgo‐García, Jose Alberto Molina‐Tijeras, Laura López‐Escanez, Luckman Gbati, Teresa Vezza, Patricia Diez‐Echave, Antonio Jesús Ruiz‐Malagón, Jorge García‐García, Federico García, Alberto Baños, Lidia Gil‐Martínez, Rocío López‐Posadas, Markus F. Neurath, Julio Gálvez, María Elena Rodríguez‐Cabezas, Alba Rodríguez‐Nogales   +16 more
wiley   +1 more source

Dietary Carbohydrates Modify Azoxymethane-Induced Intestinal Carcinogenesis in Rats ,

The Journal of Nutrition, 1994
The effect of different dietary carbohydrates (sucrose, cornstarch and high amylose cornstarch) on intestinal carcinogenesis was studied in male Sprague-Dawley rats treated subcutaneously with azoxymethane (AOM) at a weekly dose of 8 mg/kg body wt for 8 wk.
CADERNI, GIOVANNA, LUCERI, CRISTINA, M. T. Spagnesi, A. Giannini, BIGGERI, ANNIBALE, DOLARA, PIERO   +5 more
openaire   +4 more sources

Study on the effect and mechanism of Lacticaseibacillus rhamnosus AFY06 on inflammation-associated colorectal cancer induced by AOM/DSS in mice

Frontiers in Microbiology
IntroductionLacticaseibacillus rhamnosus AFY06 (LR-AFY06) is a microorganism isolated from naturally fermented yogurt in Xinjiang, China.MethodsIn this study, we investigated the effects and mechanisms of LR-AFY06 in a mouse model of inflammation ...
Jing Zhang, Piyun Zhang, Sijia Li, Ting Yu, Xiangyu Lai, Yongpeng He   +5 more
doaj   +1 more source

Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats.

PLoS ONE, 2014
BackgroundBased on the potential of Schiff base compounds to act as sources for the development of cancer chemotherapeutic agents, this in vivo study was performed to investigate the inhibitory properties of the synthetic Schiff base compound Cu(BrHAP)2 ...
Maryam Hajrezaie, Pouya Hassandarvish, Soheil Zorofchian Moghadamtousi, Nura Suleiman Gwaram, Shahram Golbabapour, Abdrabuh Najihussien, Amel Abdullah Almagrami, Maryam Zahedifard, Elham Rouhollahi, Hamed Karimian, Somaye Fani, Behnam Kamalidehghan, Nazia Abdul Majid, Hapipah Mohd Ali, Mahmood Ameen Abdulla   +14 more
doaj   +1 more source

Gut microbiota mediated the toxicity of high concentration of dietary nitrite in C57BL/6 mice

Ecotoxicology and Environmental Safety, 2022
Growing evidence indicates that exposure to high levels of nitrite for a prolonged time has adverse health effects. Although gut microbiota is responsible for the transformation of nitrite in the gut, the evidence concerning whether gut microbiota ...
Jing Xu, Mingzhu Wang, Qiuping Liu, Xiaoying Lin, Kefeng Pu, Zhixing He   +5 more
doaj   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Comparison of 2 different mouse models of colorectal cancer and their application

陆军军医大学学报
Objective To establish and compare the characteristics of mouse models of colorectal cancer (CRC) induced by inflammation and gene mutation. Methods Inflammation-induced colorectal cancer mouse model was established using azoxymethane (AOM) combined with
FENG Jianhua, LIU Xiangjun, HUANG Yujun
doaj   +1 more source

Study of superoxide dismutase's expression in the colon produced by azoxymethane and inositol hexaphosfate's paper, in mice Estudo da expressão de superóxido dismutase no cólon produzida por azoximetano e o papel do inositol hexafosfato, em ratos

Acta Cirúrgica Brasileira, 2006
PURPOSE: To investigate the expression of superoxide dismutase (SOD), with use of antioxidant inositol hexaphosfate, in the presence of the carcinogen azoxymethane, in FCA of colon rats.
Eva Glória Abrão Siufi do Amaral, Djalma José Fagundes, Guido Marks, Celso Massachi Inouye   +3 more
doaj   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source