Acta Cirúrgica Brasileira, 2011 PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II -
Roberta Alves Higa +4 more
doaj +2 more sources
Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats. [PDF]
PLoS ONE, 2014 BackgroundBased on the potential of Schiff base compounds to act as sources for the development of cancer chemotherapeutic agents, this in vivo study was performed to investigate the inhibitory properties of the synthetic Schiff base compound Cu(BrHAP)2 ...
Maryam Hajrezaie +14 more
doaj +4 more sources
EFEK PEMBERIAN EKSTRAK DAUN CARICA PUBESCENS TERHADAP JUMLAH NEUTROFIL PADA TIKUS SPRAGUE DAWLEY YANG DIINDUKSI AZOXYMETHANE [PDF]
Jurnal Kedokteran Diponegoro, 2019 Latar Belakang : Inflamasi yang terjadi terus menerus adalah salah satu penyebab terjadinya kanker kolorektal. Ekstrak daun Carica pubescens mengandung flavonoid yang memiliki efek antiinflamasi diyakini mampu menurunkan jumlah sel neutrofil.
Faradilla Nadya Blezeinsky +2 more
doaj +3 more sources
Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane [PDF]
Acta Cirúrgica Brasileira, 2019 Purpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM). Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week
Vanessa Nogueira Lages Braga +7 more
doaj +2 more sources
Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development. [PDF]
PLoS ONE, 2013 The selenoprotein glutathione peroxidase-2 (GPx2) appears to have a dual role in carcinogenesis. While it protected mice from colon cancer in a model of inflammation-triggered carcinogenesis (azoxymethane and dextran sodium sulfate treatment), it ...
Mike F Müller +7 more
doaj +2 more sources
Revista do Colégio Brasileiro de Cirurgiões, 2013 OBJETIVO: Avaliar as repercussões hepáticas da carcinogênese colônica induzida por diferentes doses e tempos de exposição ao azoximetano em ratos Wistar. MÉTODOS: Quarenta e quatro ratos foram distribuídos em quatro grupos. Os animais tinham oito semanas
Idália Maria Brasil Burlamaqui +8 more
doaj +1 more source
Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate [PDF]
Molecular Carcinogenesis, 2015 The association between inflammation and the risk of colorectal cancer (CRC) is well documented in animal models and in humans, but the mechanistic role of inflammation in CRC is less well understood. To address this question, the induction of colon tumors was evaluated in (i) wild type (WT) and athymic BALB/c mice treated with the colon carcinogen ...
Whetstone, Ryan D. +4 more
openaire +3 more sources
A Novel Mouse Model of Intrahepatic Cholangiocarcinoma Induced by Azoxymethane
International Journal of Molecular Sciences, 2023 Cholangiocarcinoma is the second most common primary cancer of the liver and has a poor prognosis. Various animal models, including carcinogen-induced and genetically engineered rodent models, have been established to clarify the mechanisms underlying cholangiocarcinoma development.
Yohei Shirakami +10 more
openaire +2 more sources
Colon tumor promotion, is it a selection process? Effects of cholate, phytate, and food restriction in rats on proliferation and apoptosis in normal and aberrant crypts [PDF]
, 1997 Promotion would suppose the selection of initiated cells. We tested the selection of aberrant crypt cells by cholic acid, a colon cancer promoter, and the effect of protectors, phytate and food restriction.
Peiffer, Ginette +5 more
core +1 more source
Freeze-Dried Ham Promotes Azoxymethane-Induced Mucin-Depleted Foci and Aberrant Crypt Foci in Rat Colon [PDF]
, 2010 Processed and red meat consumption is associated with the risk of colorectal cancer. Meta-analyses have suggested that the risk associated with processed meat is higher. Most processed meats are cured and cooked, which leads to formation of free nitrosyl
Françoise Guéraud +17 more
core +1 more source