Results 11 to 20 of about 8,111 (184)
Parvimonas micra promotes carcinogenesis of colorectal cancer through phenyllactic acid-induced DNA damage. [PDF]
Clin Transl MedMultiomics analysis of the faecal samples from CRC patients found that upregulation of P. micra and PLA was associated with the CRC development. PLA from P. micra via pdhD genes could induce DNA damage via AHR signalling pathway to mediate carcinogenesis.
Guo S +15 more
europepmc +2 more sources
A Novel Mouse Model of Intrahepatic Cholangiocarcinoma Induced by Azoxymethane
International Journal of Molecular Sciences, 2023 Cholangiocarcinoma is the second most common primary cancer of the liver and has a poor prognosis. Various animal models, including carcinogen-induced and genetically engineered rodent models, have been established to clarify the mechanisms underlying cholangiocarcinoma development.
Yohei Shirakami +10 more
openaire +2 more sources
Colon carcinogenesis in wild type and immune compromised mice after treatment with azoxymethane, and azoxymethane with dextran sodium sulfate [PDF]
Molecular Carcinogenesis, 2015 The association between inflammation and the risk of colorectal cancer (CRC) is well documented in animal models and in humans, but the mechanistic role of inflammation in CRC is less well understood. To address this question, the induction of colon tumors was evaluated in (i) wild type (WT) and athymic BALB/c mice treated with the colon carcinogen ...
Whetstone, Ryan D. +4 more
openaire +3 more sources
Marine Drugs, 2013 Muricid molluscs are a natural source of brominated isatin with anticancer activity. The aim of this study was to examine the safety and efficacy of synthetic 6-bromoisatin for reducing the risk of early stage colorectal tumor formation. The purity of 6-
Babak Esmaeelian +3 more
doaj +1 more source
Revista Científica, 2022 Colorectal Cancer (CRC) is defined as colon and rectum cancer and is among the major causes of mortality in developed Countries. Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander distillate (NOD) are reported to have anticancer and ...
Ozgur Ozdemir +2 more
doaj +1 more source
Biomedicines, 2022 Colorectal cancer (CRC) is a malignant disease that is the second most common cancer worldwide. CRC arises from the complex interactions among a variety of genetic and environmental factors. To understand the mechanism of colon tumorigenesis, preclinical
Chuangen Li +3 more
doaj +1 more source
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. [PDF]
PLoS ONE, 2013 Ptp4a3 (commonly known as PRL-3) is an enigmatic member of the Ptp4a family of prenylated protein tyrosine phosphatases that are highly expressed in many human cancers.
Mark W Zimmerman +2 more
doaj +1 more source
Enhancement by neurotensin of experimental carcinogenesis induced in rat colon by azoxymethane [PDF]
British Journal of Cancer, 1990 The effects of neurotensin on the incidence, number, size, and histology of colon tumours induced by azoxymethane (AOM) were investigated in Wistar rats. Rats were given 10 weekly injections of AOM (7.4 mg kg-1 body weight) and were also given 200 micrograms kg-1 of neurotensin in depot form every other day until the end of the experiment.
M, Tasuta +3 more
openaire +2 more sources
Frontiers in Immunology, 2017 Natural killer (NK) cells are an essential component of innate immunity against cancer development. Many studies have been conducted to evaluate immune-modulating effects using dietary compounds.
Pan Pan +10 more
doaj +1 more source
Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development. [PDF]
PLoS ONE, 2013 The selenoprotein glutathione peroxidase-2 (GPx2) appears to have a dual role in carcinogenesis. While it protected mice from colon cancer in a model of inflammation-triggered carcinogenesis (azoxymethane and dextran sodium sulfate treatment), it ...
Mike F Müller +7 more
doaj +1 more source