Results 1 to 10 of about 15,703 (232)
ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice [PDF]
Toxins, 2017 There is a geographic inequality in the incidence of colorectal cancer, lowest in developing countries, and greatest in developed countries.
Peng Li +3 more
doaj +3 more sources
Targeted deletion of the metastasis-associated phosphatase Ptp4a3 (PRL-3) suppresses murine colon cancer. [PDF]
PLoS ONE, 2013 Ptp4a3 (commonly known as PRL-3) is an enigmatic member of the Ptp4a family of prenylated protein tyrosine phosphatases that are highly expressed in many human cancers.
Mark W Zimmerman +2 more
doaj +7 more sources
Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer
Biomolecules, 2021 Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems.
Shirley James +11 more
doaj +1 more source
Current Issues in Molecular Biology, 2022 A polyphenolic component of ginger, 6-gingerol, is widely reported to possess antioxidant, anti-inflammatory and anticancer activities. In the current study, it was aimed to investigate the anticancer effects of 6-gingerol (6-Gin) on azoxymethane (AOM ...
Abdulaziz A. Aloliqi
doaj +1 more source
Metabolites, 2021 Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat versus 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a ...
Huawei Zeng +3 more
doaj +1 more source
Dietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Dietary phytate is known to protect against azoxymethane (AOM)-induced preneoplastic lesions. The present study was designed to determine whether dietary phytate affects mutation frequency in colon epithelial cells challenged with ...
Poorna Venkata Satya Prasad Pallem +2 more
doaj +1 more source
Epigenetics, 2021 Because ADAM17 promotes colonic tumorigenesis, we investigated potential miRNAs regulating ADAM17; and examined effects of diet and tumorigenesis on these miRNAs.
Urszula Dougherty +24 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Irritable bowel disease (IBD), which results in an elevated risk of colitis-associated colorectal cancer (CAC), is characterized by inflammation and barrier disruption of the gut.
Hee-Young Kim +7 more
doaj +1 more source
Manipulation of the Gut Microbiota Reveals Role in Colon Tumorigenesis
mSphere, 2016 There is growing evidence that individuals with colonic adenomas and carcinomas harbor a distinct microbiota. Alterations to the gut microbiota may allow the outgrowth of bacterial populations that induce genomic mutations or exacerbate tumor-promoting ...
Joseph P. Zackular +3 more
doaj +1 more source
Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved [PDF]
, 2011 Red meat and processed meat intake is associated with a risk of colorectal cancer, a major cause of death in affluent countries. Epidemiological and experimental evidence supports the hypothesis that heme iron present in meat promotes colorectal cancer ...
Bingham +24 more
core +4 more sources