Results 1 to 10 of about 8,111 (184)
Journal of Coloproctology, 2014 The induced colorectal carcinogenesis in rodents has a long history and currently uses the substances 1,2-dimethylhydrazine and azoxymethane. Objective: The aim of this study was to compare the inductive effect of the substances azoxymethane and 1,2 ...
Mario Jorge Jucá +3 more
exaly +3 more sources
Cardamonin Attenuates Experimental Colitis and Associated Colorectal Cancer
Biomolecules, 2021 Cardamonin is a naturally occurring chalcone, majorly from the Zingiberaceae family, which includes a wide range of spices from India. Herein, we investigated the anti-inflammatory property of cardamonin using different in vitro and in vivo systems.
Shirley James +11 more
doaj +1 more source
Current Issues in Molecular Biology, 2022 A polyphenolic component of ginger, 6-gingerol, is widely reported to possess antioxidant, anti-inflammatory and anticancer activities. In the current study, it was aimed to investigate the anticancer effects of 6-gingerol (6-Gin) on azoxymethane (AOM ...
Abdulaziz A. Aloliqi
doaj +1 more source
Metabolites, 2021 Consumption of a high-fat diet (HFD) links obesity to colon cancer in humans. Our data show that a HFD (45% energy fat versus 16% energy fat in an AIN-93 diet (AIN)) promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation in a ...
Huawei Zeng +3 more
doaj +1 more source
Dietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): Dietary phytate is known to protect against azoxymethane (AOM)-induced preneoplastic lesions. The present study was designed to determine whether dietary phytate affects mutation frequency in colon epithelial cells challenged with ...
Poorna Venkata Satya Prasad Pallem +2 more
doaj +1 more source
Epigenetics, 2021 Because ADAM17 promotes colonic tumorigenesis, we investigated potential miRNAs regulating ADAM17; and examined effects of diet and tumorigenesis on these miRNAs.
Urszula Dougherty +24 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Irritable bowel disease (IBD), which results in an elevated risk of colitis-associated colorectal cancer (CAC), is characterized by inflammation and barrier disruption of the gut.
Hee-Young Kim +7 more
doaj +1 more source
Manipulation of the Gut Microbiota Reveals Role in Colon Tumorigenesis
mSphere, 2016 There is growing evidence that individuals with colonic adenomas and carcinomas harbor a distinct microbiota. Alterations to the gut microbiota may allow the outgrowth of bacterial populations that induce genomic mutations or exacerbate tumor-promoting ...
Joseph P. Zackular +3 more
doaj +1 more source
American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice
Journal of Ginseng Research, 2015 Background: Colorectal cancer is a leading cause of cancer-related death, and inflammatory bowel disease is a risk factor for this malignancy. We previously reported colon cancer chemoprevention potential using American ginseng (AG) in a xenograft mice ...
Chunhao Yu +9 more
doaj +1 more source
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
Revista Científica, 2023 Colon cancer (CRC) is one of the most common types of cancer in the world. In this study, the effects of Tarantula cubensis alcoholic extract (TCAE) and the Capecitabine in CRC were investigated. Wistar albino rats were divided into eight groups with 12
Rahmi Canbar +2 more
doaj +1 more source