Results 41 to 50 of about 8,111 (184)

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, Volume 13, Issue 34, 19 June 2026.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

EFEK PEMBERIAN EKSTRAK DAUN Carica pubescens TERHADAP JUMLAH LEUKOSIT PADA TIKUS Sprague Dawley YANG DIINDUKSI AZOXYMETHANE : STUDI DI LABORATORIUM PENELITIAN DAN PENGUJIAN TERPADU 4 UNIVERSITAS GADJAH MADA

Jurnal Kedokteran Diponegoro, 2019
Latar belakang: Inflamasi adalah salah satu faktor penyebab terjadinya kanker kolorektal. Flavonoid adalah suatu senyawa yang terkandung dalam daun Carica pubescens diyakini memiliki efek antiinflamasi.
Eka Meyliana Sugeng, Ainun Rahmasari Gumay, Saekhol Bakri   +2 more
doaj   +1 more source

Reelin Protects against Colon Pathology via p53 and May Be a Biomarker for Colon Cancer Progression

Biology, 2022
Previous observations made in human and mouse colons suggest that reelin protects the colon from pathology. In this study, we evaluated reelin expression during the transition from either colitis or precancerous lesions to colon cancer and tried to ...
José M. Serrano-Morales, María D. Vázquez-Carretero, Pablo García-Miranda, Ana E. Carvajal, María L. Calonge, Anunciación A. Ilundain, María J. Peral   +6 more
doaj   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, Volume 3, Issue 2, Page 163-184, June 2026.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Genetic and microbial determinants of azoxymethane-induced colorectal tumor susceptibility in Collaborative Cross mice and their implication in human cancer

Gut Microbes
The insights into interactions between host genetics and gut microbiome (GM) in colorectal tumor susceptibility (CTS) remains lacking. We used Collaborative Cross mouse population model to identify genetic and microbial determinants of Azoxymethane ...
Dan Li, Chenhan Zhong, Mengyuan Yang, Li He, Hang Chang, Ning Zhu, Susan E Celniker, David W Threadgill, Antoine M Snijders, Jian-Hua Mao, Ying Yuan   +10 more
doaj   +1 more source

Study of the antineoplastic action of Tabebuia avellanedae in carcinogenesis induced by azoxymethane in mice Estudo da ação antineoplásica da Tabebuia avellanedae (Ipê-Roxo) na carcinogênese induzida pelo azoximetano em camundongos

Acta Cirúrgica Brasileira, 2011
PURPOSE: To study the antitumor action of Tabebuia avellanedae in experimentally induced colon carcinogenesis by azoxymethane in mice. METHODS: Fifty (n=50) mice were divided into five groups: in group I azoxymethane (AOM) was administered, in Group II -
Roberta Alves Higa, Ricardo Dutra Aydos, Iandara Schettert Silva, Rondon Tosta Ramalho, Albert Schiaveto de Souza   +4 more
doaj   +1 more source

Correlation Between THSD7A Expression and Tumor Characteristics of Azoxymethane-Induced Colon Cancer Model in Rats

The Turkish Journal of Gastroenterology, 2021
Background: Thrombospondin type 1 domain-containing 7A (THSD7A) has emerged as a new potential molecular tool for multiple tumors since that THSD7A was detected to be expressed in various malignant tumor types including colorectal cancer (CRC).
Oktay Halit Aktepe, Taha Koray Sahin, Gurkan Guner, Deniz Can Guven, Haci Hasan Yeter, Olcay Kurtulan, Ibrahim Hanifi Ozercan, Omer Dizdar, Suayib Yalcin   +8 more
doaj   +1 more source

Tectochrysin Ameliorates Colitis‐Associated Colon Cancer in Mice Via the Activation of Mitophagy in Intestinal Epithelial Cells

Molecular Nutrition &Food Research, Volume 70, Issue 11, 15 June 2026.
Tectochrysin (TEC) activates Foxo3a/Pink1/Parkin‐mediated mitophagy in intestinal epithelial cells, restoring mitochondrial homeostasis and reducing ROS, thereby ameliorating AOM/DSS‐induced colitis‐associated colon cancer (CAC) in mice. ABSTRACT Tectochrysin (TEC), a natural flavonoid, has shown efficacy in ameliorating chronic colitis.
Jikai He, Yuanmei Lou, Qichen Huang, Jinliang Dong, Qifeng Yu   +4 more
wiley   +1 more source

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu, Chujuan Cui, Lingdong Kong, Qiang Xu, Haibo Cheng, Lisha Zhou, Yang Sun   +6 more
wiley   +1 more source

The signal pathways in azoxymethane-induced colon cancer and preventive implications [PDF]

Cancer Biology & Therapy, 2009
Colon cancer is the third most common cancer and third most common cause of cancer-related death in the USA according to 2008 American Cancer Society statistics. The carcinogenesis of colon cancer has been associated with both genetics and environmental factors. It has been found that several signal pathways, including K-ras, Src/PI3K/Akt, beta-catenin,
Chen, Jiezhong, Huang, Xu-Feng
openaire   +5 more sources