Results 181 to 190 of about 15,583 (213)
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Effect of black tea on azoxymethane-induced colon cancer
Carcinogenesis, 1998Two sets of experiments on the role of tea in azoxymethane (AOM) induced colon cancer were performed. The first test involved male F344 rats given 1.25% solutions of black tea beginning at 5 weeks of age and ending at 51 days of age. At 6 and 7 weeks of age, they received 15 mg/kg AOM and were held for 50 weeks. Another group received the AOM dosage at
J H, Weisburger +6 more
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AZOXYCOMPOUNDS: I. THE PHOTOLYSIS OF AZOXYMETHANE
Canadian Journal of Chemistry, 1964A study of the photolysis of azoxymethane has been made. The reaction products include nitrogen, nitrous oxide, methane, and ethane. The ratio N2:N2O is independent of temperature and two primary photolytic processes are postulated to account for this fact.
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Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol
Cancer Prevention Research, 2019Abstract This study evaluated the preclinical activity of δ-tocotrienol (DT3), a bioactive form of vitamin E, in the inhibition of colorectal cancer growth and development in vitro and in vivo. DT3 is the most bioactive isomer of vitamin E in inhibiting growth of colorectal cancer cells.
Kazim Husain +6 more
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Dietary Iron Promotes Azoxymethane-Induced Colon Tumors in Mice
Nutrition and Cancer, 2004There is accumulating evidence that high levels of dietary iron may play a role in colon carcinogenesis. We used a mouse model to investigate the impact of elevated dietary iron on incidence of aberrant crypt foci (ACF; a preneoplastic lesion) on tumor formation and on induction of oxidative stress. A/J mice were injected intraperitoneally, once a week
Jillian N M, Ilsley +9 more
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The Azoxymethane/Il10 −/− Model of Colitis-Associated Cancer (CAC)
2019Mouse models have proved essential for generating a mechanistic understanding of human disease processes. The azoxymethane/interleukin-10 knockout (AOM/Il10-/-) model is a powerful tool for assessing the effects of intestinal microbiota and inflammation on colon tumorigenesis.
Aaron, Rothemich, Janelle C, Arthur
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Factor VIII expression in azoxymethane-induced murine fulminant hepatic failure
Blood, 2002AbstractFulminant hepatic failure (FHF) in humans produces a bleeding diathesis due in large part to a reduction in the biosynthesis of liver-derived coagulation factors. Remarkably, factor VIII procoagulant activity is elevated in most of these patients despite widespread liver cell death.
Christopher B, Doering +3 more
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Effects of adlay on azoxymethane-induced colon carcinogenesis in rats
Food and Chemical Toxicology, 2004Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a grass crop used in traditional Chinese medicine and as a nutritious food. It has been reported that adlay has anti-inflammatory and anti-tumor activity. Cyclooxygenase-2 (COX-2) is an inducible enzyme functionally related to both inflammation and colon carcinogenesis and is the target of many ...
Chun-Kuang, Shih +2 more
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Beer Inhibition of Azoxymethane-Induced Colonic Carcinogenesis
2009Abstract Modulatory effects of beer intake on azoxymethane (AOM)-induced rat colonic carcinogenesis in male Fischer 344 rats were investigated. Single cell gel electrophoresis assay indicated that DNA damage of colonocytes, induced by a single AOM injection (15 mg/kg body weight), was significantly reduced in rats fed beer or malt extract for 2 ...
Hajime Nozawa, Keiji Kondo
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Mixed Tocopherols Inhibit Azoxymethane-Induced Aberrant Crypt Foci in Rats
Nutrition and Cancer, 2006Gamma (gamma) tocopherol, but not alpha (alpha) tocopherol (vitamin E), has previously been reported as an effective inhibitor of cyclooxygenase (COX) enzyme activity. In a pilot study of 17 rats, mixed tocopherols containing more than 50% gamma-tocopherol, added at 0.1% to an AIN-76A diet, produced a significant inhibition (about 55%) of azoxymethane ...
Harold L, Newmark +2 more
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Dry Beans Inhibit Azoxymethane-Induced Colon Carcinogenesis in F344 Rats
The Journal of Nutrition, 1997Epidemiological studies show a low incidence of colon cancer in many Latin American countries where the consumption of dry beans (e.g., pinto) is high. The purpose of this study was to use rats as an animal model to obtain experimental data on the inhibition of colon carcinogenesis by dry beans.
J S, Hughes +2 more
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