Results 191 to 200 of about 15,583 (213)

Inhibition of carcinogenicities of 1,2-dimethylhydrazine and azoxymethane by pyrazole

Cancer Letters, 1982
Inhibitory effects of pyrazole on the carcinogenicities of 2 large-bowel carcinogens, 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM), were examined, because our previous study revealed that pyrazole completely inhibited the induction of mutations by these carcinogens in the host-mediated mutation assay.
M, Moriya, T, Harada, Y, Shirasu
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Enhancement of azoxymethane‐induced colon carcinogenesis in spontaneously hypertensive rats

International Journal of Cancer, 1990
AbstractThe incidence, number, location, and histological types of colon tumors induced by azoxymethane (AOM) and the tissue norepinephrine concentration of the colon wall were investigated in spontaneously hypertensive (SH) rats and in control normotensive Wistar Kyoto (WKY) rats. All rats received 10 weekly s.c. injections of AOM.
M, Tatsuta, H, Iishi, M, Baba, H, Taniguchi   +3 more
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Citrus nobiletin inhibits azoxymethane‐induced large bowel carcinogenesis in rats

BioFactors, 2004
AbstractThe inhibitory effects of dietary feeding of citrus nobiletin on azoxymethane (AOM)‐induced rat colon carcinogenesis using a long‐term bioassay were investigated. Five‐week old male F344 rats were initiated with two weekly subcutaneous injections of AOM (20 mg/kg bw) to induce colonic tumors. They were also given the diets containing 0.01% or 0.
Rikako, Suzuki, Hiroyuki, Kohno, Akira, Murakami, Koichi, Koshimizu, Hajime, Ohigashi, Masamichi, Yano, Harukuni, Tokuda, Hoyoku, Nishino, Takuji, Tanaka   +8 more
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Quantitative assessment of azoxymethane-inducedaberrant crypt foci in inbred mice

Experimental and Molecular Pathology, 1999
Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk.
D A, Delker, Q S, Wang, A, Papanikolaou, H E, Whiteley, D W, Rosenberg   +4 more
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Neurobiological characterization of an azoxymethane mouse model of acute liver failure

Neurochemistry International, 2006
Molecular biological approaches continue to lead to the identification of alterations in expression of genes coding for key central nervous system proteins involved in water homeostasis, energy metabolism and neurotransmitter regulation in acute liver failure (ALF).
Mireille, Bélanger, Jean, Côté, Roger F, Butterworth   +2 more
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Xanthohumol protects against Azoxymethane‐induced colorectal cancer in Sprague‐Dawley rats

Environmental Toxicology, 2019
AbstractColorectal cancer (CRC) is a major health problem and third most common deaths in western world. Dietary interventions together with modified dietary style can prevent the CRC in humans. Xanthohumol (XHA), a polyphenol isolated from Humulus lupulus L. contains many beneficial effects.
Hualin Liu, Lei Zhang, Guanghua Li, Zhuanglei Gao   +3 more
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Differential Expression of p16INK4a in Azoxymethane-Induced Mouse Colon Tumorigenesis

Molecular Carcinogenesis, 2000
Alterations in the p16(INK4a) gene have been implicated in the pathogenesis of different human cancers and animal tumors. We postulated that alterations in the p16(INK4a) gene may also be involved in mouse colon tumorigenesis induced by the chemical carcinogen azoxymethane (AOM).
Q S, Wang, A, Papanikolaou, P R, Nambiar, D W, Rosenberg   +3 more
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Dietary Guar Gum Alters Colonic Microbial Fermentation in Azoxymethane-Treated Rats

The Journal of Nutrition, 1996
To assess the effects of guar gum on colonic microbial fermentation and cancer development, azoxymethane-treated rats were fed a partially hydrolyzed guar or control diet. Anaerobic fecal incubations were conducted at 8-wk intervals, either without added substrate or with cornstarch or hydrolyzed guar as substrates.
G A, Weaver, C, Tangel, J A, Krause, H D, Alpern, P L, Jenkins, M M, Parfitt, J J, Stragand   +6 more
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Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1

Carcinogenesis, 1991
The metabolism of azoxymethane (AOM), methylazoxymethanol (MAM) and N-nitrosodimethylamine (NDMA) by liver microsomes from acetone-induced rats as well as by a reconstituted system containing purified cytochrome P450IIE1 was examined. The products consisted of MAM from AOM; methanol and formic acid from MAM; and methylamine, formaldehyde, methanol ...
O S, Sohn, H, Ishizaki, C S, Yang, E S, Fiala   +3 more
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Effect of tea on the formation of DNA adducts by azoxymethane

Xenobiotica, 1998
1. The effect of black tea on the conversion of azoxymethane (AOM) to DNA reactive metabolites was studied in four groups of the male F344 rat. Each received 1.25% solutions of tea for 2 or 6 weeks, and simultaneous controls drank water. All rats were injected s.c. twice with 15 mg/kg AOM after the first or fifth week respectively, on tea or water, and
W, Chen, O S, Sohn, E S, Fiala, J H, Weisburger   +3 more
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