Results 141 to 150 of about 16,733 (229)

Clin Infect Dis [PDF]

The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern.

core  

Diagnostic algorithm for the detection of carbapenemases and extended-spectrum β-lactamases in carbapenem-resistant Pseudomonas aeruginosa [PDF]

Pseudomonas aeruginosa can acquire carbapenem resistance through various mechanisms, including genomic mutations leading to the overexpression of efflux pumps, intrinsic AmpC-β-lactamase, and/or reduced permeability, and/or through the acquisition of ...
Egli, Adrian, Garcia-Verellen, Laia, Hinic, Vladimira, Keller, Peter M, Kolesnik-Goldmann, Natalia, Mancini, Stefano, Nolte, Oliver, Roloff, Tim, Seth-Smith, Helena M B, Syed, Muhammad Ali, Ullah, Irfan   +10 more
core   +1 more source

Emergence of high-level aztreonam–avibactam and cefiderocol resistance following treatment of an NDM-producing Escherichia coli bloodstream isolate exhibiting reduced susceptibility to both agents at baseline

JAC-Antimicrobial Resistance
Background Cefiderocol (FDC) or ceftazidime-avibactam with aztreonam (CZA-ATM) are frontline agents for New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales; however, clinical data are scarce, and mechanisms of treatment-emergent resistance are
G. Haidar, Ellen G. Kline, G. Kitsios, Xiaohong Wang, Eun J. Kwak, Anthony Newbrough, Kelly Friday, K. Hughes Kramer, R. K. Shields   +8 more
semanticscholar   +1 more source

Activities of aztreonam in combination with several novel β-lactam-β-lactamase inhibitor combinations against carbapenem-resistant Klebsiella pneumoniae strains coproducing KPC and NDM

Frontiers in Microbiology
Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options.
Xinhui Li, Jisheng Zhang, Jianmin Wang, Wenzhang Long, Xushan Liang, Yang Yang, Xue Gong, Jie Li, Longjin Liu, Xiaoli Zhang   +9 more
doaj   +1 more source

Wide dissemination of Gram-negative bacteria producing the taniborbactam-resistant NDM-9 variant: a One Health concern [PDF]

, 2023
Buchs, Chloé, Castanheira, Mariana, Di, Doris Yoong Wen, Le Terrier, Christophe, Nordmann, Patrice, Poirel, Laurent, Rossolini, Gian Maria, Stephan, Roger   +7 more
core   +1 more source

Activity of cefiderocol and innovative β-lactam/β-lactamase inhibitor combinations against isogenic strains of Escherichia coli expressing single and double β-lactamases under high and low permeability conditions [PDF]

[Objectives] To analyse the impact of the most clinically relevant β-lactamases and their interplay with low outer membrane permeability on the activity of cefiderocol, ceftazidime/avibactam, aztreonam/avibactam, cefepime/enmetazobactam, cefepime ...
Blanco-Martín, Tania, Alonso-García, Isaac, González-Pinto, Lucía, Outeda-García, Michelle, Guijarro-Sánchez, Paula, López-Hernández, Inmaculada, Perez-Vazquez, Maria, Aracil, Belen, López-Cerero, Lorena, Fraile-Ribot, Pablo, Oliver, Antonio, Vázquez-Ucha, Juan Carlos, Beceiro, Alejandro, Bou, Germán, Arca-Suárez, Jorge, GEMARA/SEIMC-CIBERINFEC Study Group on the activity and resistance mechanisms to new β-lactams and β-lactamase inhibitors (PROTECT)   +15 more
core   +2 more sources

Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations [PDF]

Unlabelled: The emergence of carbapenemase-producing Enterobacterales represents a significant clinical challenge. Resistance mechanisms involve carbapenemase production, porin and efflux pump alterations, penicillin-binding protein (PBP) modifications ...
Angelini, Jacopo, Arcamone, Celeste, Bernaschi, Paola, Bulfoni, Michela, Curcio, Francesco, Di Gennaro, Ciro, Ferin, Sara, Fox, Valeria, Giuliano, Simone, Gualandi, Nicolò, Krpan, Beatrice, Manzi, Rosa, Martini, Luca, Moreal, Chiara, Perno, Carlo Federico, Pipan, Corrado, Stanziola, Maria Cristina, Tascini, Carlo, Turco, Sara   +18 more
core   +1 more source

Synergistic combination of ceftazidime and avibactam with Aztreonam against MDR Klebsiella pneumoniae in ICU patients

Scientific Reports
The proliferation of multidrug-resistant, metallo-beta-lactamase-producing Klebsiella pneumoniae (MBL-producing K. pneumoniae) poses a major threat to public health resulting in increasing treatment costs, prolonged hospitalization, and mortality rate ...
Sally Khattab, Aya Mohamed Askar, Hidi A. A. Abdellatif, Amira A. A. Othman, Amal H. Rayan, Hasnaa Azab   +5 more
doaj   +1 more source

In vitro activity of aztreonam–avibactam combination against blood culture isolates of Stenotrophomonas maltophilia in Japan before the launch of ceftazidime–avibactam

Microbiology spectrum
to evaluate the in vitro activity of AZT–AVI against S.
Wataru Aoki, Y. Uwamino, Yuka Kamoshita, Rika Inose, Mika Nagata, Naoki Hasegawa, Hiromichi Matsushita   +6 more
semanticscholar   +1 more source

Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying blaNDM-5 and blaKPC-3 from foreign fighters evacuated from Ukraine

Antimicrobial Agents and Chemotherapy
Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying blaNDM-5, blaKPC-3, blaCTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany.
Melissa J. Martin, Ting L. Luo, V. Kovalchuk, V. Kondratiuk, Henry D Dao, I. Kovalenko, Brandon J. Plaza, Joanna M Kettlewell, Cole P Anderson, Jason R Smedberg, Ana C Ong, Yoon I Kwak, Joshua S Hawley-Molloy, Jason W. Bennett, P. McGann, François Lebreton   +15 more
semanticscholar   +1 more source