Results 71 to 80 of about 6,022 (216)

Tryptophan to Tryptophan Hole Hopping in an Azurin Construct

The Journal of Physical Chemistry B, 2023
Electron transfer (ET) between neutral and cationic tryptophan residues in the azurin construct [ReI(H126)(CO)3(dmp)](W124)(W122)CuI (dmp = 4,7-Me2-1,10-phenanthroline) was investigated by Born-Oppenheimer quantum-mechanics/molecular mechanics/molecular dynamics (QM/MM/MD) simulations.
Martin Melčák, Filip Šebesta, Jan Heyda, Harry B. Gray, Stanislav Záliš, Antonín Vlček   +5 more
openaire   +4 more sources

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures, Volume 7, Issue 3, March 2026.
Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
wiley   +1 more source

Safety evaluation of the food enzyme endo‐1,4‐β‐xylanase from the genetically modified Trichoderma reesei strain Dp‐Nzd66

EFSA Journal, Volume 24, Issue 3, March 2026.
Abstract The food enzyme endo‐1,4‐β‐xylanase (4‐β‐d‐xylan xylanohydrolase; EC 3.2.1.8) is produced with the genetically modified Trichoderma reesei strain DP‐Nzd66 by Genencor International B.V. The genetic modifications do not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA. It
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Jaime Aguiera, Magdalena Andryszkiewicz, Ana Criado, Yi Liu   +17 more
wiley   +1 more source

Synchrotron structural biology at SSRL, the beginning and beyond

Journal of Synchrotron Radiation, Volume 33, Issue 1, Page 7-17, January 2026.
It has been 50 years since the publication in PNAS of our first results on the utilization and demonstrated benefits of synchrotron radiation for macromolecular crystallography. In this brief article, I offer some personal observations and comments about that early research at Stanford and the Stanford Synchrotron Radiation Project (SSRP, later renamed
Keith Hodgson
wiley   +1 more source

Anti-cancer peptides from bacteria

Bangladesh Journal of Pharmacology, 2013
Cancer is a leading cause of death in the world. The rapid development of medicine and pharmacology allows to create new and effective anticancer drugs. Among modern anticancer drugs are bacterial proteins.
Tomasz M. Karpinski, Anna K. Szkaradkiewicz   +1 more
doaj   +2 more sources

Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa

Data in Brief, 2015
Crc is a post-transcriptional regulator in Pseudomonas aeruginosa that modulates its metabolism, but also its susceptibility to antibiotics and virulence. Most of P. aeruginosa virulence factors are secreted or engulfed in vesicles.
Jose Antonio Reales-Calderón, Fernando Corona, Lucía Monteoliva, Concha Gil, Jose Luis Martínez   +4 more
doaj   +1 more source

A Euclidean perspective on the unfolding of azurin: chain motion [PDF]

JBIC Journal of Biological Inorganic Chemistry, 2013
We present a new approach to visualizing and quantifying the displacement of segments of Pseudomonas aeruginosa azurin in the early stages of denaturation. Our method is based on a geometrical method developed previously by the authors, and elaborated extensively for azurin. In this study, we quantify directional changes in three α-helical regions, two
Gray, Harry B., Warren, Jeffrey J., Winkler, Jay R., Kozak, John J.   +3 more
openaire   +3 more sources

Bacteriocins as a Promising Antimicrobial Strategy Against Multidrug‐Resistant Pathogens: Mechanisms of Action, Applications in Human and Animal Health, and the Food Industry

BioMed Research International, Volume 2026, Issue 1, 2026.
The global rise of antimicrobial resistance has significantly increased the difficulty treating infectious agents, creating an urgent need for alternative therapeutic strategies. In this context, bacteriocins have emerged as a promising solution, offering a potential alternative to conventional antibacterial therapies.
Abdo Megra Geda, Aregash Wendimu Tumebo, Solomon Lulie Abey, Gashaw Enbiyale Kasse, Abraham Belete Temesgen, Zerihun Getie Wassie, Baisakhi Banerjee   +6 more
wiley   +1 more source

Single-step Purification and Characterization of Pseudomonas aeruginosa Azurin. [PDF]

Azurin is a small periplasmic blue copper protein found in bacterial strains such as Pseudomonas and Alcaligenes where it facilitates denitrification. Azurin is extensively studied for its ability to mediate electron-transfer processes, but it has also ...
Horváth, M, Šulc, M, Sýkora, J, Šebesta, F, Riegerová, P, Vlček, A   +5 more
core   +1 more source