Results 131 to 140 of about 16,488,690 (299)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integrating bioinformatics to explore HPV-31 and HPV-52 E6/E7 proteins: from structural analysis to antigenic epitope prediction

Frontiers in Immunology
IntroductionCervical cancer is the most common malignant neoplasm of the female reproductive tract. Infection with human papillomavirus (HPV) has been strongly associated with cervical cancer.
Qixue Cai, Yifan Feng, Wenbo Dong, Yanling Meng   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1 [PDF]

, 2012
HLA class I-associated polymorphisms identified at the population level mark viral sites under immune pressure by individual HLA alleles. As such, analysis of their distribution, frequency, location, statistical strength, sequence conservation, and other
Nelson, G., Carrington, M., Haubrich, R., Knapp, D.J.H.F., DeZiel, C.E., John, M., Brumme, Z.L., Carlson, J.M., Brumme, C.J., Listgarten, J., Riddler, S.A., Pfeifer, N., Apps, R., Harrigan, P.R., Heckerman, D., Le, A.Q., Cotton, L.A., Martin, E., Chui, C.K.S., Brockman, M.A., Mallal, S.   +20 more
core  

Targeted T and B cell epitopes on CS protein.

, 2015
(A) Schematic representation of the existing (upper panel) and novel (lower panel) hybrid Pb/Pf sporozoites. Native P. berghei sequence is indicated by light shading and transgenic P. falciparum sequence by dark shading.
Fidel P. Zavala (690624), David C. Whitacre (733760), Amy E. Tucker (733763), David R. Milich (733765), Darrell L. Peterson (733764), Diego A. Espinosa (531079), Joyce E. Jones (733762), Cory J. Peters (733761)   +7 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age

Nature Communications
Influenza B viruses (IBVs) cause substantive morbidity and mortality, and yet immunity towards IBVs remains understudied. CD8+ T-cells provide broadly cross-reactive immunity and alleviate disease severity by recognizing conserved epitopes.
Tejas Menon, Patricia T. Illing, Priyanka Chaurasia, Hayley A. McQuilten, Chloe Shepherd, Louise C. Rowntree, Jan Petersen, Dene R. Littler, Grace Khuu, Ziyi Huang, Lilith F. Allen, Steve Rockman, Jane Crowe, Katie L. Flanagan, Linda M. Wakim, Thi H. O. Nguyen, Nicole A. Mifsud, Jamie Rossjohn, Anthony W. Purcell, Carolien E. van de Sandt, Katherine Kedzierska   +20 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source