Results 121 to 130 of about 16,488,690 (299)
AMB ExpressT and B cell activation are equally important in triggering and orchestrating adaptive host responses to design multi-epitope African swine fever virus (ASFV) vaccines.
Ting-Yu Chen +5 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Predicted MHC and B-cell epitopes.
, 2017 Epitopes within the reference sequence of (A) HPV-33 E6 protein; (B) HPV-33 E7 protein; (C) HPV-58 E6 protein; and (D) HPV-58 E7 protein. Red indicates a consensus of the predicted MHC I epitopes binding not less than 10 HLA I alleles.
Man Cao (3708154) +7 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Mapping of human B-cell epitopes of Sindbis virus
Journal of General Virology, 2016 Mosquito-transmitted Sindbis virus (SINV) causes fever, skin lesions and musculoskeletal symptoms if transmitted to man. SINV is the prototype virus of genus Alphavirus, which includes other arthritogenic viruses such as chikungunya virus (CHIKV) and Ross River virus (RRV) that cause large epidemics with a considerable public health burden.
Hepojoki Jussi +7 more
openaire +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
B cell epitopes in candidate antigens.
, 2013 Linear B cell epitopes (12 amino acid lengths) were predicted using a BCPred tool (http://ailab.cs.iastate.edu/bcpreds/).
Juan C. Vázquez-Chagoyán (102097) +11 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Characterization and prediction of B-cell epitopes [PDF]
, 2019 A B-cell epitope is a set of antigen surface residues which can be recognized by an antibody. Identifying epitopes facilitates the understanding of the basic recognition mechanism of immune responses, which in turn guides disease diagnosis, vaccine design and drug development.
openaire +2 more sources