Results 101 to 110 of about 16,488,690 (299)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction [PDF]

, 2016
X-ray crystallography has shown that an antibody paratope typically binds 15-22 amino acids (aa) of an epitope, of which 2-5 randomly distributed amino acids contribute most of the binding energy.
Chowdhury, Erfan U., Rahman, K.S., Sachse, Konrad, Rahman, Kh. Shamsur, Kaltenboeck, B., Kaltenboeck, Bernhard, Chowdhury, E.U.   +6 more
core   +1 more source

Computational assembly of a human Cytomegalovirus vaccine upon experimental epitope legacy

BMC Bioinformatics, 2019
Background Human Cytomegalovirus (HCMV) is a ubiquitous herpesvirus affecting approximately 90% of the world population. HCMV causes disease in immunologically naive and immunosuppressed patients.
Monica J. Quinzo, Esther M. Lafuente, Pilar Zuluaga, Darren R. Flower, Pedro A. Reche   +4 more
doaj   +1 more source

In Silico Identification and in Vitro Analysis of B and T-Cell Epitopes of the Black Turtle Bean (Phaseolus Vulgaris L.) Lectin

Cellular Physiology and Biochemistry, 2018
Background/Aims: The incidence of lectin allergic disease is increasing in recent decades, and definitive treatment is still lacking. Identification of B and T-cell epitopes of allergen will be useful in understanding the allergen antibody responses as ...
Shudong He, Jinlong Zhao, Walid Elfalleh, Mohamed Jemaà, Hanju  Sun, Xianbao Sun, Mingming Tang, Qian He, Zeyu Wu, Florian Lang   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection [PDF]

, 2008
During acute human immunodeficiency virus type 1 (HIV-1) infection, early host cellular immune responses drive viral evolution. The rates and extent of these mutations, however, remain incompletely characterized.
Carrington, M., Brumme, Z. L., John, M., Altfeld, M., Streeck, H., Markowitz, M., Block, B. L., Kaldor, J., Heckerman, D., Kelleher, A. D., Carlson, J., Jessen, H., Kadie, C., Yuki, Y., Rosenberg, E., Walker, B. D., Eichbaum, Q., Baker, B., Allen, T. M., Brumme, C. J., Mallal, S.   +20 more
core  

Potential predicted B-cell epitopes of SHNP.

, 2019
Potential predicted B-cell epitopes of SHNP.
Thiago Santos Chaves (8129283), Fernando de Paiva Conte (8129277), Patricia Cristina da Costa Neves (8129292), Renata Carvalho de Oliveira (8129286), Ronaldo Mohana-Borges (86170), Janaina Figueira Mansur (8129289), Elba Regina Sampaio de Lemos (2697328), Rodrigo Nunes Rodrigues-da-Silva (7407458), Bianca Corrêa Tinoco (8129280)   +8 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Conservation of PRRSV GP5 B-cell/T-cell epitopes.

, 2019
Conservation of PRRSV GP5 B-cell/T-cell epitopes.
Joan A. Smyth (6281486), Antonio E. Garmendia (6281492), Antonio Costa (2453434), Yan Pan (5477), Caitlin M. O’Connell (6281483), Paulo H. Verardi (473579), Diane J. Burgess (2068993), Herbert J. Van Kruiningen (6281489), Junru Cui (6281480)   +8 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source