Results 161 to 170 of about 16,488,690 (299)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Antibody-specific B-cell epitopes prediction
, 2016 B细胞表位是抗原中可被效应B细胞产生的抗体特异性识别并结合的部位，B细胞表位分为构象表位（非连续表位）和线性表位（连续表位），在自然界中90%的B细胞表位都属于构象表位，确定B细胞表位对于理解疾病的发病机制、识别潜在的自身抗原以及疫苗的设计研发有着极为重要的意义。目前检测B细胞表位的实验方法都是费力且资源密集型，由此，一些简便的计算型方法被开发出来进行B细胞表位预测，以便为实验方法提供方向性指导。然而，大部分计算型方法只是粗略地将输入抗原表面区域划分成表位和非表位两种情况而不考虑是针对哪种抗体的表位 ...
林一奇
core
Multi-perspectives and challenges in identifying B-cell epitopes. [PDF]
Protein Sci, 2023 Kumar N +3 more
europepmc +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Immunodominant B-cell epitopes for precision surveillance of <i>Plasmodium vivax</i> malaria. [PDF]
Emerg Microbes InfectZhao H +13 more
europepmc +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Novel Linear B Cell Epitopes of ASFV p54: Screening and Fine-Scale Mapping. [PDF]
MicroorganismsWang H +8 more
europepmc +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source