Results 261 to 270 of about 16,488,690 (299)

Advances in In-silico B-cell Epitope Prediction

Current Topics in Medicinal Chemistry, 2019
Identification of B-cell epitopes in target antigens is one of the most crucial steps for epitopebased vaccine development, immunodiagnostic tests, antibody production, and disease diagnosis and therapy. Experimental methods for B-cell epitope mapping are time consuming, costly and labor intensive; in the meantime, various in-silico methods are ...
Pingping, Sun, Sijia, Guo, Jiahang, Sun, Liming, Tan, Chang, Lu, Zhiqiang, Ma   +5 more
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Prediction of Linear B Cell Epitopes in Proteins

2023
The accurate prediction of B cell epitopes is crucial for the design and development of vaccines, especially of those preventive for emerging pathogenic diseases. Preventive vaccines are mainly based on the induction of highly specific neutralizing antibodies.
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Mimotope-Based Prediction of B-Cell Epitopes

2014
Mimotopes are peptides mimicking epitopes on the corresponding antigen. They can be obtained via panning the phage-displayed random peptide library against the corresponding monoclonal antibody or specific sera. Besides mimotopes however, the experimental results also include all kinds of unwanted sequences called "target-unrelated peptides," which ...
Jian, Huang, Bifang, He, Peng, Zhou
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Molecular Approaches to the Study of B Cell Epitopes

International Reviews of Immunology, 1991
For some years, a major goal of immunochemistry has been to determine the molecular architecture of the antibody-combining site and its cognate surface on the antigen, the antigenic determinant or epitope, and to determine the molecular basis of specificity and affinity. In recent years, the crystal structures of several antigen-antibody complexes have
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B-cell epitopes of scleroderma-specific autoantigens

Molecular Biology Reports, 1992
It can be concluded that the precise localization of the epitopes on autoantigens associated with scleroderma has not been determined yet, and further subcloning experiments will be required to map the epitopes more precisely. However, the fact that the antigenicities of the C-terminal ends of topo I as well as of CENP-B are highly affected by the ...
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B-cell epitopes of RNA autoantigens

Molecular Biology Reports, 1992
R M, Hoet, W J, van Venrooij
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Sequential order of T and B cell epitopes affects immunogenicity but not antibody recognition of the B cell epitope.

Peptide research, 1995
Synthetic peptide constructs, co-linearly linking a MUC1 mucin B cell epitope peptide to a known murine T cell epitope, both in T-B and B-T orientations, show that induction of high murine anti-MUC1 antibody titers is dependent on the presence and orientation of the T cell determinant.
G, Denton, F, Hudecz, J, Kajtár, A, Murray, S J, Tendler, M R, Price   +5 more
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B-cell epitopes of the Nef protein

Research in Virology, 1992
R, Spohn, F O, Gombert, G, Jung
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[Linear B-cell epitope prediction].

Molekuliarnaia biologiia, 2009
Combination of sliding window method with physical properties scale of amino acids is a classical approach for linear B-cell epitope prediction. But it was shown that accuracy of these methods is poor. We reviewed classical and new algorithms of epitope prediction and present own implementation of one of them.
Ia I, Davydov, A G, Tonevitskiĭ
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B-cell epitopes of Sm autoantigens

Molecular Biology Reports, 1992
L A, Rokeach, S O, Hoch
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